SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lo9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 5lo9 CYTOCHROME C
(Marichromatium
purpuratum) 		4 / 6 TYR A 398
TYR A 469
HIS A 473
PRO A 422
 None
None
None
HEC  A1004 (-4.0A)
 1.36A 1q13A-5lo9A:
undetectable		 1q13A-5lo9A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5lo9 CYTOCHROME C
(Marichromatium
purpuratum) 		4 / 8 THR A 369
GLY A 366
THR A 365
ALA A 364
 None
None
EDO  A1022 (-3.2A)
None
 0.79A 2a1hA-5lo9A:
undetectable
2a1hB-5lo9A:
undetectable		 2a1hA-5lo9A:
21.30
2a1hB-5lo9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 5lo9 CYTOCHROME C
(Marichromatium
purpuratum) 		4 / 5 ALA A 108
ALA A 187
ALA A  95
VAL A  99
 None
 0.85A 2nyrB-5lo9A:
undetectable		 2nyrB-5lo9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 5lo9 CYTOCHROME C
(Marichromatium
purpuratum) 		4 / 8 ARG A 475
ARG A 332
GLN A 338
HIS A 437
 None
None
CL  A1013 (-4.0A)
None
 1.47A 2vxaA-5lo9A:
undetectable
2vxaC-5lo9A:
undetectable
2vxaE-5lo9A:
undetectable		 2vxaA-5lo9A:
8.85
2vxaC-5lo9A:
8.85
2vxaE-5lo9A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 5lo9 CYTOCHROME C
(Marichromatium
purpuratum) 		4 / 8 HIS A 437
ARG A 475
ARG A 332
GLN A 338
 None
None
None
CL  A1013 (-4.0A)
 1.49A 2vxaD-5lo9A:
undetectable
2vxaJ-5lo9A:
undetectable
2vxaL-5lo9A:
undetectable		 2vxaD-5lo9A:
8.85
2vxaJ-5lo9A:
8.85
2vxaL-5lo9A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5lo9 CYTOCHROME C
(Marichromatium
purpuratum) 		4 / 7 GLN A 477
GLY A 501
GLY A 512
ALA A 489
 None
 0.72A 3fpjB-5lo9A:
undetectable		 3fpjB-5lo9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5lo9 CYTOCHROME C
(Marichromatium
purpuratum) 		4 / 7 ASN A 431
TYR A 500
ARG A 438
ARG A 480
 None
 1.11A 3twpB-5lo9A:
undetectable		 3twpB-5lo9A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5lo9 CYTOCHROME C
(Marichromatium
purpuratum) 		4 / 6 CYH A  21
GLY A  30
GLY A  29
ASP A  28
 HEC  A1001 (-1.7A)
None
None
None
 0.90A 5a06D-5lo9A:
undetectable		 5a06D-5lo9A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5lo9 CYTOCHROME C
(Marichromatium
purpuratum) 		4 / 4 VAL A  80
GLY A   5
ARG A   4
VAL A  75
 HEC  A1001 (-4.4A)
None
None
None
 1.33A 5d4nA-5lo9A:
undetectable
5d4nB-5lo9A:
undetectable		 5d4nA-5lo9A:
12.89
5d4nB-5lo9A:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 5lo9 CYTOCHROME C
(Marichromatium
purpuratum) 		3 / 3 PHE A  55
ARG A 159
ALA A  38
 None
HEC  A1002 ( 3.4A)
HEC  A1001 (-3.6A)
 0.89A 6ecfB-5lo9A:
undetectable		 6ecfB-5lo9A:
21.64