SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5loa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 ARG A  99
ALA A 106
PRO A  77
ALA A  80
 None
 0.95A 2ejfA-5loaA:
undetectable		 2ejfA-5loaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 PHE A  34
ILE A  33
GLY A  32
VAL A  46
ALA A   7
 None
 0.99A 3fpjA-5loaA:
3.2		 3fpjA-5loaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 5 GLU A 183
GLN A 139
HIS A 141
GLY A 185
 None
 1.31A 3pp1A-5loaA:
undetectable		 3pp1A-5loaA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 4 VAL A 302
PHE A 281
PHE A  63
VAL A  61
 None
 1.49A 3rv5C-5loaA:
undetectable
3rv5D-5loaA:
undetectable		 3rv5C-5loaA:
16.67
3rv5D-5loaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 6 MET A  28
ASP A  27
ARG A 283
HIS A 286
 None
 1.30A 4cevA-5loaA:
undetectable
4cevC-5loaA:
undetectable		 4cevA-5loaA:
21.78
4cevC-5loaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 6 ARG A 283
HIS A 286
MET A  28
ASP A  27
 None
 1.29A 4cevD-5loaA:
undetectable
4cevE-5loaA:
undetectable		 4cevD-5loaA:
21.78
4cevE-5loaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 6 ARG A 283
HIS A 286
MET A  28
ASP A  27
 None
 1.30A 4cevE-5loaA:
undetectable
4cevF-5loaA:
undetectable		 4cevE-5loaA:
21.78
4cevF-5loaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 4 LEU A  14
ILE A 279
GLY A  15
PHE A  63
 NAP  A 401 (-4.2A)
None
None
None
 0.85A 4dc3A-5loaA:
5.0		 4dc3A-5loaA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 4 VAL A 134
ALA A 131
ASN A 127
GLN A 140
 None
 1.43A 4zgfA-5loaA:
undetectable		 4zgfA-5loaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 9 ALA A 203
ASP A 202
ASP A 205
ILE A 209
ILE A 230
 None
 1.21A 5kr2A-5loaA:
undetectable		 5kr2A-5loaA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 9 ALA A 203
ASP A 202
ASP A 205
ILE A 209
ILE A 230
 None
 1.20A 5kr2C-5loaA:
undetectable		 5kr2C-5loaA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 THR A 117
ALA A 275
ASP A 272
SER A  17
 None
 1.12A 5l5fY-5loaA:
undetectable
5l5fZ-5loaA:
undetectable		 5l5fY-5loaA:
19.63
5l5fZ-5loaA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 TRP A 119
MET A 123
ASN A 127
 NAP  A 401 (-4.2A)
None
None
 1.24A 5uc1B-5loaA:
undetectable		 5uc1B-5loaA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 TRP A 119
MET A 123
ASN A 127
 NAP  A 401 (-4.2A)
None
None
 1.20A 5uc1A-5loaA:
undetectable		 5uc1A-5loaA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 6 ALA A  50
LYS A  78
GLN A  75
ASP A  71
 None
 1.30A 5y9aA-5loaA:
1.8		 5y9aA-5loaA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 TYR A 168
PRO A 146
LEU A 170
 None
 0.89A 6beoA-5loaA:
undetectable		 6beoA-5loaA:
4.84