SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5loe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 5loe GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Bacillus
subtilis) 		5 / 12 LEU A 179
LYS A 223
ILE A 190
LEU A 221
ILE A 230
 None
 0.93A 2d0kA-5loeA:
undetectable		 2d0kA-5loeA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 5loe GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Bacillus
subtilis) 		5 / 12 LEU A 224
VAL A 229
GLY A 228
LEU A 179
ALA A 175
 None
 0.93A 2egvA-5loeA:
undetectable		 2egvA-5loeA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)		 5loe GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Bacillus
subtilis) 		5 / 10 LEU A 224
VAL A 229
GLY A 228
LEU A 179
ALA A 175
 None
 0.94A 2v3kA-5loeA:
undetectable		 2v3kA-5loeA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 5loe GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Bacillus
subtilis) 		3 / 3 LYS A 205
LYS A 238
VAL A 202
 None
 0.66A 3brfA-5loeA:
undetectable		 3brfA-5loeA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 5loe GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Bacillus
subtilis) 		5 / 9 VAL A 150
VAL A 149
VAL A 114
ILE A 116
GLY A 118
 None
 1.22A 4fwdA-5loeA:
undetectable		 4fwdA-5loeA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5loe GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY
(Bacillus
subtilis) 		3 / 3 ASP A 195
ASN A 197
PHE A 249
 None
 0.79A 5dsgB-5loeA:
undetectable		 5dsgB-5loeA:
20.82