SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5loh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		3 / 3 VAL A 766
VAL A 812
TRP A 762
 None
 0.80A 1av2A-5lohA:
undetectable
1av2B-5lohA:
undetectable		 1av2A-5lohA:
5.49
1av2B-5lohA:
5.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		7 / 12 VAL A  49
ALA A  60
VAL A  94
ASN A 161
LEU A 163
THR A 173
ASP A 174
 None
STU  A 901 (-3.3A)
None
STU  A 901 ( 4.8A)
STU  A 901 (-4.5A)
STU  A 901 (-3.5A)
STU  A 901 (-4.1A)
 0.74A 1fmoE-5lohA:
26.4		 1fmoE-5lohA:
34.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		3 / 3 VAL A 766
VAL A 812
TRP A 762
 None
 0.81A 1w5uA-5lohA:
undetectable
1w5uB-5lohA:
undetectable		 1w5uA-5lohA:
5.49
1w5uB-5lohA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 9 VAL A  49
ALA A  60
MET A 110
GLY A 116
LEU A 163
 None
STU  A 901 (-3.3A)
STU  A 901 (-3.7A)
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
 0.49A 1xbbA-5lohA:
21.1		 1xbbA-5lohA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 12 ALA A  60
GLY A 116
LEU A 163
THR A 173
PHE A 175
 STU  A 901 (-3.3A)
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
STU  A 901 (-3.5A)
None
 0.44A 1xkkA-5lohA:
16.7		 1xkkA-5lohA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		7 / 12 VAL A  49
ALA A  60
MET A 110
TYR A 112
LYS A 158
ASN A 161
ASP A 174
 None
STU  A 901 (-3.3A)
STU  A 901 (-3.7A)
STU  A 901 (-4.6A)
None
STU  A 901 ( 4.8A)
STU  A 901 (-4.1A)
 0.68A 2fumB-5lohA:
21.1		 2fumB-5lohA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		6 / 12 SER A  42
ALA A  60
LEU A 108
GLY A 116
LEU A 163
THR A 173
 STU  A 901 ( 4.8A)
STU  A 901 (-3.3A)
None
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
STU  A 901 (-3.5A)
 0.67A 2itoA-5lohA:
20.3		 2itoA-5lohA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		3 / 3 VAL A 812
TRP A 762
VAL A 766
 None
 0.71A 2izqC-5lohA:
undetectable
2izqD-5lohA:
undetectable		 2izqC-5lohA:
5.49
2izqD-5lohA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_D_SC2D1290_1
(FICOLIN-2)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		4 / 5 TRP A 761
TRP A 762
ARG A 823
LEU A 815
 CL  A 902 (-4.2A)
None
None
None
 1.40A 2j2pD-5lohA:
undetectable
2j2pF-5lohA:
undetectable		 2j2pD-5lohA:
17.51
2j2pF-5lohA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_B_AZZB1211_1
(DEOXYNUCLEOSIDE
KINASE)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 12 TRP A 840
LEU A 142
GLN A 846
VAL A 838
MET A 848
 None
 1.38A 2jj8B-5lohA:
undetectable		 2jj8B-5lohA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 11 LEU A 122
VAL A 118
LEU A 144
MET A 132
ILE A 170
 None
 1.16A 2uxoB-5lohA:
undetectable		 2uxoB-5lohA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_B_FMMB91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		7 / 12 VAL A  49
ALA A  60
LEU A  96
GLY A 116
LEU A 163
THR A 173
PHE A 175
 None
STU  A 901 (-3.3A)
None
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
STU  A 901 (-3.5A)
None
 0.63A 3bbtB-5lohA:
17.7		 3bbtB-5lohA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		7 / 12 VAL A  49
ALA A  60
LEU A 108
GLY A 116
LEU A 163
THR A 173
PHE A 175
 None
STU  A 901 (-3.3A)
None
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
STU  A 901 (-3.5A)
None
 0.55A 3bbtD-5lohA:
18.4		 3bbtD-5lohA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUP_B_MI1B1_1
(TYROSINE-PROTEIN
KINASE JAK2)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		7 / 12 VAL A  49
ALA A  60
VAL A  94
MET A 110
TYR A 112
LEU A 113
LEU A 163
 None
STU  A 901 (-3.3A)
None
STU  A 901 (-3.7A)
STU  A 901 (-4.6A)
STU  A 901 (-4.1A)
STU  A 901 (-4.5A)
 0.39A 3fupB-5lohA:
10.2		 3fupB-5lohA:
27.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		6 / 11 VAL A  49
ALA A  60
VAL A  94
TYR A 112
GLY A 116
LEU A 163
 None
STU  A 901 (-3.3A)
None
STU  A 901 (-4.6A)
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
 0.35A 3g0eA-5lohA:
16.5		 3g0eA-5lohA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		6 / 11 VAL A  49
ALA A  60
TYR A 112
GLY A 116
ASP A 117
LEU A 163
 None
STU  A 901 (-3.3A)
STU  A 901 (-4.6A)
STU  A 901 (-3.5A)
STU  A 901 (-4.2A)
STU  A 901 (-4.5A)
 0.40A 3g0fA-5lohA:
16.6		 3g0fA-5lohA:
27.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 10 PHE A 835
GLU A 828
LEU A 764
LEU A 768
ILE A 137
 None
 1.08A 3kvrA-5lohA:
undetectable		 3kvrA-5lohA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		6 / 12 VAL A  49
ALA A  60
VAL A  94
TYR A 112
GLY A 116
LEU A 163
 None
STU  A 901 (-3.3A)
None
STU  A 901 (-4.6A)
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
 0.38A 3sxrA-5lohA:
22.0		 3sxrA-5lohA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		6 / 12 VAL A  49
ALA A  60
VAL A  94
TYR A 112
GLY A 116
LEU A 163
 None
STU  A 901 (-3.3A)
None
STU  A 901 (-4.6A)
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
 0.34A 3sxrB-5lohA:
21.7		 3sxrB-5lohA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 9 ALA A  60
VAL A  94
ASP A 117
LYS A 119
LEU A 163
 STU  A 901 (-3.3A)
None
STU  A 901 (-4.2A)
None
STU  A 901 (-4.5A)
 1.09A 3ti1A-5lohA:
24.1		 3ti1A-5lohA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 9 VAL A  94
ASP A 117
LYS A 119
LEU A 163
ASP A 174
 None
STU  A 901 (-4.2A)
None
STU  A 901 (-4.5A)
STU  A 901 (-4.1A)
 0.97A 3ti1A-5lohA:
24.1		 3ti1A-5lohA:
26.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		8 / 12 VAL A  49
ALA A  60
LEU A 108
MET A 110
GLY A 116
LEU A 163
THR A 173
ASP A 174
 None
STU  A 901 (-3.3A)
None
STU  A 901 (-3.7A)
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
STU  A 901 (-3.5A)
STU  A 901 (-4.1A)
 0.75A 4i22A-5lohA:
17.1		 4i22A-5lohA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		8 / 12 VAL A  49
ALA A  60
ASP A 117
ASP A 156
LYS A 158
ASN A 161
LEU A 163
ASP A 174
 None
STU  A 901 (-3.3A)
STU  A 901 (-4.2A)
None
None
STU  A 901 ( 4.8A)
STU  A 901 (-4.5A)
STU  A 901 (-4.1A)
 0.58A 4i41A-5lohA:
21.9		 4i41A-5lohA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		6 / 10 ALA A  60
VAL A  94
MET A 110
LEU A 113
GLY A 115
LEU A 163
 STU  A 901 (-3.3A)
None
STU  A 901 (-3.7A)
STU  A 901 (-4.1A)
None
STU  A 901 (-4.5A)
 0.94A 4ks8A-5lohA:
22.1		 4ks8A-5lohA:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		7 / 10 ILE A  41
ALA A  60
VAL A  94
MET A 110
LEU A 113
GLY A 116
LEU A 163
 STU  A 901 (-4.3A)
STU  A 901 (-3.3A)
None
STU  A 901 (-3.7A)
STU  A 901 (-4.1A)
STU  A 901 (-3.5A)
STU  A 901 (-4.5A)
 0.73A 4ks8A-5lohA:
22.1		 4ks8A-5lohA:
29.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 8 ILE A  41
VAL A  49
ALA A  60
ASN A 161
LEU A 163
 STU  A 901 (-4.3A)
None
STU  A 901 (-3.3A)
STU  A 901 ( 4.8A)
STU  A 901 (-4.5A)
 0.58A 4ogrA-5lohA:
18.1		 4ogrA-5lohA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		6 / 9 ILE A  41
VAL A  49
ALA A  60
ASN A 161
LEU A 163
ASP A 174
 STU  A 901 (-4.3A)
None
STU  A 901 (-3.3A)
STU  A 901 ( 4.8A)
STU  A 901 (-4.5A)
STU  A 901 (-4.1A)
 0.76A 4ogrI-5lohA:
22.7		 4ogrI-5lohA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_I_ADNI401_1
(CYCLIN-DEPENDENT
KINASE 9)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		6 / 9 VAL A  49
ALA A  60
ASP A 117
ASN A 161
LEU A 163
ASP A 174
 None
STU  A 901 (-3.3A)
STU  A 901 (-4.2A)
STU  A 901 ( 4.8A)
STU  A 901 (-4.5A)
STU  A 901 (-4.1A)
 0.78A 4ogrI-5lohA:
22.7		 4ogrI-5lohA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		6 / 12 VAL A  49
ALA A  60
MET A 110
TYR A 112
LEU A 113
LEU A 163
 None
STU  A 901 (-3.3A)
STU  A 901 (-3.7A)
STU  A 901 (-4.6A)
STU  A 901 (-4.1A)
STU  A 901 (-4.5A)
 0.42A 4qmzA-5lohA:
24.8		 4qmzA-5lohA:
29.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 12 TYR A 744
LEU A 157
VAL A 140
ILE A 137
LEU A 816
 None
 1.25A 4yvpB-5lohA:
undetectable		 4yvpB-5lohA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 9 ALA A 811
LEU A 764
GLY A 765
LEU A 768
LEU A 834
 None
 1.05A 5dqfA-5lohA:
undetectable		 5dqfA-5lohA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 12 LEU A 764
ILE A 153
GLY A 756
ARG A 155
LEU A 815
 None
 1.15A 5h5fA-5lohA:
undetectable		 5h5fA-5lohA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		6 / 12 ILE A  41
VAL A  49
ALA A  60
VAL A  94
ASP A 117
LEU A 163
 STU  A 901 (-4.3A)
None
STU  A 901 (-3.3A)
None
STU  A 901 (-4.2A)
STU  A 901 (-4.5A)
 0.59A 5l2iA-5lohA:
8.3		 5l2iA-5lohA:
27.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		6 / 12 ILE A  41
VAL A  49
ALA A  60
VAL A  94
ASP A 117
LEU A 163
 STU  A 901 (-4.3A)
None
STU  A 901 (-3.3A)
None
STU  A 901 (-4.2A)
STU  A 901 (-4.5A)
 0.74A 5l2tA-5lohA:
8.4		 5l2tA-5lohA:
27.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5N3H_A_NCAA401_0
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		7 / 10 VAL A  49
ALA A  60
VAL A  94
MET A 110
TYR A 112
LEU A 163
THR A 173
 None
STU  A 901 (-3.3A)
None
STU  A 901 (-3.7A)
STU  A 901 (-4.6A)
STU  A 901 (-4.5A)
STU  A 901 (-3.5A)
 0.65A 5n3hA-5lohA:
29.2		 5n3hA-5lohA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 12 GLY A 825
ALA A 824
ILE A 137
SER A 810
ILE A 814
 None
 1.00A 5t2zA-5lohA:
undetectable		 5t2zA-5lohA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 9 ALA A  60
VAL A  94
MET A 110
GLY A 115
THR A 173
 STU  A 901 (-3.3A)
None
STU  A 901 (-3.7A)
None
STU  A 901 (-3.5A)
 0.87A 5w5vA-5lohA:
15.0		 5w5vA-5lohA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W5V_A_ANWA701_0
(SERINE/THREONINE-PRO
TEIN KINASE TBK1)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 9 ALA A  60
VAL A  94
MET A 110
GLY A 116
THR A 173
 STU  A 901 (-3.3A)
None
STU  A 901 (-3.7A)
STU  A 901 (-3.5A)
STU  A 901 (-3.5A)
 0.46A 5w5vA-5lohA:
15.0		 5w5vA-5lohA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		5 / 12 VAL A  49
ALA A  60
LEU A 108
GLY A 116
THR A 173
 None
STU  A 901 (-3.3A)
None
STU  A 901 (-3.5A)
STU  A 901 (-3.5A)
 0.62A 5yu9C-5lohA:
16.9		 5yu9C-5lohA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		4 / 6 GLU A 130
LEU A 834
LEU A 804
LEU A 772
 None
 1.00A 5yvnA-5lohA:
undetectable		 5yvnA-5lohA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL
(Homo
sapiens) 		4 / 5 PRO A 742
VAL A 786
GLY A 774
VAL A 766
 None
 0.98A 6ak3B-5lohA:
undetectable		 6ak3B-5lohA:
13.96