SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5loi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 5loi RAD26
(Thermothelomyces
thermophila) 		4 / 6 ASN A 516
HIS A 455
TYR A 454
GLY A 451
 None
 1.19A 1mxdA-5loiA:
undetectable		 1mxdA-5loiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 5loi RAD26
(Thermothelomyces
thermophila) 		4 / 7 ASN A 516
HIS A 455
TYR A 454
GLY A 451
 None
 1.15A 1mxgA-5loiA:
undetectable		 1mxgA-5loiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5loi RAD26
(Thermothelomyces
thermophila) 		4 / 5 ASP A 439
PRO A 481
VAL A 482
ILE A 438
 None
 0.93A 2aoiA-5loiA:
undetectable		 2aoiA-5loiA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5loi RAD26
(Thermothelomyces
thermophila) 		4 / 5 ASP A 439
PRO A 481
VAL A 482
ILE A 438
 None
 0.99A 2aoiB-5loiA:
undetectable		 2aoiB-5loiA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		5 / 10 ALA A 663
PHE A 656
ALA A 655
ARG A 651
LEU A 767
 None
 1.15A 2bxqA-5loiA:
undetectable		 2bxqA-5loiA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5loi RAD26
(Thermothelomyces
thermophila) 		5 / 12 PRO A 597
THR A 619
VAL A 616
ILE A 593
SER A 587
 None
 1.46A 2xrlA-5loiA:
undetectable		 2xrlA-5loiA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5loi RAD26
(Thermothelomyces
thermophila) 		5 / 12 MET A 559
ILE A 480
LEU A 523
ASN A 572
ALA A 529
 None
 1.11A 3a50D-5loiA:
2.5		 3a50D-5loiA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 5loi RAD26
(Thermothelomyces
thermophila) 		4 / 8 ALA A 434
ILE A 438
LEU A 460
ALA A 472
 None
 0.69A 3r9tA-5loiA:
undetectable		 3r9tA-5loiA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 5loi RAD26
(Thermothelomyces
thermophila) 		5 / 12 LEU A 752
LEU A 647
LEU A 650
ALA A 649
TRP A 577
 None
 1.20A 4fn9B-5loiA:
undetectable		 4fn9B-5loiA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 5loi RAD26
(Thermothelomyces
thermophila) 		4 / 6 ALA A 667
LEU A 767
VAL A 768
ASP A 775
 None
 1.04A 4g24A-5loiA:
5.1		 4g24A-5loiA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 5loi RAD26
(Thermothelomyces
thermophila) 		3 / 3 SER A 531
TYR A 527
PRO A 535
 None
 0.96A 4k8cA-5loiA:
undetectable		 4k8cA-5loiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		3 / 3 SER A 531
TYR A 527
PRO A 535
 None
 0.94A 4kahA-5loiA:
undetectable		 4kahA-5loiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		3 / 3 SER A 531
TYR A 527
PRO A 535
 None
 0.95A 4kahB-5loiA:
undetectable		 4kahB-5loiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		3 / 3 SER A 531
TYR A 527
PRO A 535
 None
 0.96A 4kanA-5loiA:
undetectable		 4kanA-5loiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		3 / 3 SER A 531
TYR A 527
PRO A 535
 None
 0.97A 4kanB-5loiA:
undetectable		 4kanB-5loiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		3 / 3 SER A 531
TYR A 527
PRO A 535
 None
 0.95A 4kbeA-5loiA:
undetectable		 4kbeA-5loiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5loi RAD26
(Thermothelomyces
thermophila) 		4 / 5 LEU A 523
ARG A 488
PRO A 595
SER A 587
 None
 1.47A 4kmmB-5loiA:
undetectable		 4kmmB-5loiA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		3 / 3 SER A 531
TYR A 527
PRO A 535
 None
 0.94A 4lbgA-5loiA:
undetectable		 4lbgA-5loiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		3 / 3 SER A 531
TYR A 527
PRO A 535
 None
 0.94A 4lbgB-5loiA:
undetectable		 4lbgB-5loiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5loi RAD26
(Thermothelomyces
thermophila) 		5 / 11 LEU A 824
TYR A 793
VAL A 677
ILE A 673
SER A 780
 None
 1.42A 4lhmA-5loiA:
1.7		 4lhmA-5loiA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5loi RAD26
(Thermothelomyces
thermophila) 		5 / 12 ILE A 813
LEU A 800
VAL A 679
ALA A 683
LEU A 687
 None
 1.39A 4m11C-5loiA:
0.3		 4m11C-5loiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5loi RAD26
(Thermothelomyces
thermophila) 		5 / 12 ILE A 813
LEU A 800
VAL A 679
ALA A 683
LEU A 687
 None
 1.42A 4m11D-5loiA:
1.6		 4m11D-5loiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		5 / 10 CYH A 483
LEU A 479
LEU A 526
ALA A 529
LEU A 464
 None
 1.20A 4p65A-5loiA:
undetectable
4p65B-5loiA:
undetectable
4p65F-5loiA:
undetectable
4p65H-5loiA:
undetectable		 4p65A-5loiA:
6.88
4p65B-5loiA:
5.66
4p65F-5loiA:
5.66
4p65H-5loiA:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		5 / 12 ASP A 499
LEU A 492
SER A 569
ARG A 511
PRO A 573
 None
 1.17A 5hnwB-5loiA:
undetectable		 5hnwB-5loiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		5 / 12 ASP A 499
LEU A 492
SER A 569
ARG A 511
PRO A 573
 None
 1.21A 5hnxB-5loiA:
undetectable		 5hnxB-5loiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		5 / 12 ASP A 499
LEU A 492
SER A 569
ARG A 511
PRO A 573
 None
 1.14A 5hnyB-5loiA:
undetectable		 5hnyB-5loiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5loi RAD26
(Thermothelomyces
thermophila) 		3 / 3 VAL A 677
HIS A 765
VAL A 768
 None
 0.62A 5jmnC-5loiA:
undetectable		 5jmnC-5loiA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5loi RAD26
(Thermothelomyces
thermophila) 		5 / 12 ALA A 672
THR A 658
ARG A 585
GLY A 760
LEU A 763
 None
 1.18A 5m54E-5loiA:
2.1		 5m54E-5loiA:
20.61