SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5loq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		3 / 3 GLU A  57
TRP A  11
LYS A  67
 None
 1.41A 1qu2A-5loqA:
undetectable		 1qu2A-5loqA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		5 / 9 LEU A 245
LEU A  70
ILE A  94
PHE A  89
THR A  59
 None
 1.16A 3freX-5loqA:
undetectable		 3freX-5loqA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		5 / 11 LEU A 245
LEU A  70
ILE A  94
PHE A  89
THR A  59
 None
 1.14A 3jw5A-5loqA:
undetectable		 3jw5A-5loqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		5 / 10 LEU A 245
LEU A  70
ILE A  94
PHE A  89
THR A  59
 None
 1.12A 3jw5B-5loqA:
undetectable		 3jw5B-5loqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		3 / 3 PHE A  17
TYR A  61
LEU A  99
 None
 0.72A 3keeB-5loqA:
undetectable		 3keeB-5loqA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		5 / 7 GLY A 201
GLY A 190
LEU A  75
PHE A  73
HIS A  15
 None
 1.48A 3o9mA-5loqA:
undetectable		 3o9mA-5loqA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		3 / 3 PHE A  17
TYR A  61
LEU A  99
 None
 0.72A 3sueB-5loqA:
undetectable		 3sueB-5loqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		4 / 5 ASP A  16
THR A  74
LEU A  14
GLU A  86
 None
 1.38A 4a3pA-5loqA:
undetectable		 4a3pA-5loqA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		5 / 12 GLY A 191
TYR A 104
GLU A 109
ILE A 189
VAL A   5
 None
None
FEC  A 302 ( 4.8A)
FEC  A 302 ( 4.4A)
None
 1.21A 4fglA-5loqA:
undetectable
4fglB-5loqA:
undetectable		 4fglA-5loqA:
22.52
4fglB-5loqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		5 / 10 SER A  41
LEU A  98
LEU A  70
SER A 242
LEU A 245
 None
 0.98A 4yiaA-5loqA:
undetectable		 4yiaA-5loqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		4 / 6 SER A 103
GLY A 190
THR A   7
GLU A 109
 None
None
None
FEC  A 302 ( 4.8A)
 1.08A 5btcA-5loqA:
undetectable
5btcC-5loqA:
1.2
5btcD-5loqA:
undetectable		 5btcA-5loqA:
21.04
5btcC-5loqA:
21.04
5btcD-5loqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		4 / 6 SER A 103
GLY A 190
THR A   7
GLU A 109
 None
None
None
FEC  A 302 ( 4.8A)
 1.07A 5btcA-5loqA:
undetectable
5btcB-5loqA:
undetectable
5btcC-5loqA:
1.2		 5btcA-5loqA:
21.04
5btcB-5loqA:
23.40
5btcC-5loqA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5loq PUTATIVE
HEME-DEPENDENT
PEROXIDASE LMO2113
(Listeria
monocytogenes) 		4 / 5 SER A 103
GLY A 190
THR A   7
GLU A 109
 None
None
None
FEC  A 302 ( 4.8A)
 1.03A 5btiC-5loqA:
undetectable
5btiD-5loqA:
undetectable		 5btiC-5loqA:
21.04
5btiD-5loqA:
23.40