SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5low'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5low RABPHILIN-3A
(Rattus
norvegicus) 		3 / 3 ASP A 577
TYR A 632
LYS A 636
 CA  A 702 (-3.7A)
None
CA  A 703 ( 3.8A)
 1.08A 2othA-5lowA:
undetectable		 2othA-5lowA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5low RABPHILIN-3A
(Rattus
norvegicus) 		4 / 7 TYR A 613
LEU A 625
ASP A 626
SER A 628
 None
 1.37A 3lslA-5lowA:
undetectable
3lslD-5lowA:
undetectable		 3lslA-5lowA:
20.85
3lslD-5lowA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5low RABPHILIN-3A
(Rattus
norvegicus) 		4 / 7 SER A 628
TYR A 613
LEU A 625
ASP A 626
 None
 1.43A 3lslA-5lowA:
undetectable
3lslD-5lowA:
undetectable		 3lslA-5lowA:
20.85
3lslD-5lowA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5low RABPHILIN-3A
(Rattus
norvegicus) 		4 / 5 ILE A 634
SER A 637
LYS A 636
GLY A 635
 None
None
CA  A 703 ( 3.8A)
None
 1.02A 3tkdB-5lowA:
undetectable		 3tkdB-5lowA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5low RABPHILIN-3A
(Rattus
norvegicus) 		4 / 5 ILE A 634
SER A 637
LYS A 636
GLY A 635
 None
None
CA  A 703 ( 3.8A)
None
 1.02A 3tkdA-5lowA:
undetectable		 3tkdA-5lowA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5low SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25
(Rattus
norvegicus;
Rattus
norvegicus) 		3 / 3 MET D  71
GLU E 194
ARG E 191
 None
 0.97A 5tjyA-5lowD:
undetectable		 5tjyA-5lowD:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 5low SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25
(Rattus
norvegicus;
Rattus
norvegicus) 		3 / 3 MET D  71
GLU E 194
ARG E 191
 None
 0.96A 5tjzA-5lowD:
undetectable		 5tjzA-5lowD:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5low RABPHILIN-3A
(Rattus
norvegicus) 		4 / 5 MET A 588
TYR A 550
GLY A 556
GLY A 555
 None
 1.07A 5x7pA-5lowA:
undetectable		 5x7pA-5lowA:
7.73