SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lox'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 TYR A   2
CYH A 171
LEU A 159
MET A   6
 None
 1.41A 1uw6A-5loxA:
undetectable
1uw6B-5loxA:
undetectable		 1uw6A-5loxA:
20.99
1uw6B-5loxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 TYR A   2
CYH A 171
LEU A 159
MET A   6
 None
 1.43A 1uw6D-5loxA:
undetectable
1uw6E-5loxA:
undetectable		 1uw6D-5loxA:
20.99
1uw6E-5loxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 TYR A   2
CYH A 171
LEU A 159
MET A   6
 None
 1.42A 1uw6G-5loxA:
undetectable
1uw6H-5loxA:
undetectable		 1uw6G-5loxA:
20.99
1uw6H-5loxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 TYR A   2
CYH A 171
LEU A 159
MET A   6
 None
 1.43A 1uw6P-5loxA:
undetectable
1uw6Q-5loxA:
undetectable		 1uw6P-5loxA:
20.99
1uw6Q-5loxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 159
MET A   6
TYR A   2
CYH A 171
 None
 1.42A 1uw6P-5loxA:
undetectable
1uw6T-5loxA:
undetectable		 1uw6P-5loxA:
20.99
1uw6T-5loxA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 SER A  78
ASP A  81
SER A  72
LEU A  44
 None
 1.08A 2cdqB-5loxA:
undetectable		 2cdqB-5loxA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 THR A   1
ALA A  28
LYS A  32
ALA A  49
GLY A  50
 None
 1.11A 2f16H-5loxA:
20.2
2f16I-5loxA:
17.8		 2f16H-5loxA:
24.90
2f16I-5loxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 THR A   1
ALA A  28
LYS A  32
ALA A  49
GLY A  50
 None
 1.12A 2f16V-5loxA:
20.3
2f16W-5loxA:
20.5		 2f16V-5loxA:
24.90
2f16W-5loxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 THR A  89
LEU A  85
VAL A 113
GLY A 114
LEU A 124
 None
 0.99A 3ijdA-5loxA:
undetectable		 3ijdA-5loxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 223
ARG A  19
VAL A 186
ASP A 177
ILE A 180
 None
 1.44A 3jayA-5loxA:
undetectable		 3jayA-5loxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 223
ARG A  19
VAL A 186
ASP A 177
ILE A 180
 None
 1.42A 3jb3A-5loxA:
undetectable		 3jb3A-5loxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 THR A   1
ALA A  28
LYS A  32
ALA A  49
GLY A  50
 None
 1.16A 3mg0V-5loxA:
20.4
3mg0W-5loxA:
20.6		 3mg0V-5loxA:
24.90
3mg0W-5loxA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  15
SER A  16
ILE A 180
SER A 178
PHE A 215
 None
 1.25A 4c49A-5loxA:
undetectable		 4c49A-5loxA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 GLN A  47
ALA A   5
LEU A  12
PHE A  14
ILE A 127
 None
 1.25A 4claA-5loxA:
undetectable		 4claA-5loxA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 192
LEU A 169
ARG A 170
LEU A 173
 None
 0.77A 4wg0B-5loxA:
undetectable
4wg0C-5loxA:
undetectable		 4wg0B-5loxA:
3.93
4wg0C-5loxA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 TYR A 214
LEU A 192
LEU A 169
ARG A 170
LEU A 173
 None
 1.01A 4wg0C-5loxA:
undetectable
4wg0D-5loxA:
undetectable
4wg0E-5loxA:
undetectable		 4wg0C-5loxA:
3.93
4wg0D-5loxA:
3.93
4wg0E-5loxA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 169
ARG A 170
LEU A 173
LEU A 192
TYR A 214
 None
 1.04A 4wg0F-5loxA:
undetectable
4wg0G-5loxA:
undetectable
4wg0H-5loxA:
undetectable		 4wg0F-5loxA:
3.93
4wg0G-5loxA:
3.93
4wg0H-5loxA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 TYR A 214
LEU A 192
LEU A 169
ARG A 170
LEU A 173
 None
 1.00A 4wg0E-5loxA:
undetectable
4wg0F-5loxA:
undetectable
4wg0G-5loxA:
undetectable		 4wg0E-5loxA:
3.93
4wg0F-5loxA:
3.93
4wg0G-5loxA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 169
ARG A 170
LEU A 173
LEU A 192
TYR A 214
 None
 1.05A 4wg0H-5loxA:
undetectable
4wg0I-5loxA:
undetectable
4wg0J-5loxA:
undetectable		 4wg0H-5loxA:
3.93
4wg0I-5loxA:
3.93
4wg0J-5loxA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 169
ARG A 170
LEU A 173
LEU A 192
TYR A 214
 None
 0.97A 4wg0J-5loxA:
undetectable
4wg0K-5loxA:
undetectable
4wg0L-5loxA:
undetectable		 4wg0J-5loxA:
3.93
4wg0K-5loxA:
3.93
4wg0L-5loxA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 TYR A 214
LEU A 192
LEU A 169
ARG A 170
LEU A 173
 None
 0.99A 4wg0I-5loxA:
undetectable
4wg0J-5loxA:
undetectable
4wg0K-5loxA:
undetectable		 4wg0I-5loxA:
3.93
4wg0J-5loxA:
3.93
4wg0K-5loxA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 172
SER A 175
VAL A 174
GLN A 144
TYR A   2
 None
 1.43A 4zj8A-5loxA:
undetectable		 4zj8A-5loxA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5lox PEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  13
LEU A 159
TYR A   2
ALA A  15
LEU A 192
 None
 1.47A 6dk1B-5loxA:
undetectable		 6dk1B-5loxA:
21.76