SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5loy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		4 / 4 ILE A 113
MET A  33
VAL A 203
GLY A   5
 None
 1.44A 1e06B-5loyA:
undetectable		 1e06B-5loyA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 10 ILE A  44
ALA A  76
LEU A  62
ILE A 128
THR A  75
 None
 1.24A 1rb3A-5loyA:
undetectable		 1rb3A-5loyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 ILE A  44
ALA A  76
LEU A  62
ILE A 128
THR A  75
 None
 1.23A 3ql3A-5loyA:
undetectable		 3ql3A-5loyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.84A 4qvpH-5loyA:
7.4
4qvpI-5loyA:
20.9		 4qvpH-5loyA:
23.14
4qvpI-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.84A 4qvpV-5loyA:
6.1
4qvpW-5loyA:
20.9		 4qvpV-5loyA:
23.14
4qvpW-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 11 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.88A 4qvyH-5loyA:
7.4		 4qvyH-5loyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.89A 4qvyV-5loyA:
3.0
4qvyW-5loyA:
20.9		 4qvyV-5loyA:
23.14
4qvyW-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 11 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.86A 4qw0H-5loyA:
7.4
4qw0I-5loyA:
21.0		 4qw0H-5loyA:
23.14
4qw0I-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 11 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.86A 4qw0V-5loyA:
3.7
4qw0W-5loyA:
21.0		 4qw0V-5loyA:
23.14
4qw0W-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.85A 4qw1H-5loyA:
5.8
4qw1I-5loyA:
20.8		 4qw1H-5loyA:
23.14
4qw1I-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.85A 4qw1V-5loyA:
6.1
4qw1W-5loyA:
20.8		 4qw1V-5loyA:
23.14
4qw1W-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 ASP A 192
LEU A 193
LEU A 174
LEU A 189
ILE A 209
 None
 1.12A 4x1fA-5loyA:
undetectable		 4x1fA-5loyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 ASP A 192
LEU A 193
LEU A 174
LEU A 189
ILE A 209
 None
 1.09A 4x1gA-5loyA:
undetectable		 4x1gA-5loyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 ALA A 173
SER A 176
VAL A 175
GLN A 145
TYR A   2
 None
 1.46A 4zj8A-5loyA:
undetectable		 4zj8A-5loyA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 11 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.83A 5bxnH-5loyA:
4.6
5bxnI-5loyA:
20.9		 5bxnH-5loyA:
22.75
5bxnI-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.85A 5cz7V-5loyA:
3.7
5cz7W-5loyA:
21.0		 5cz7V-5loyA:
23.14
5cz7W-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.85A 5l5fH-5loyA:
7.4
5l5fI-5loyA:
21.0		 5l5fH-5loyA:
23.14
5l5fI-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.85A 5l5fV-5loyA:
6.2
5l5fW-5loyA:
21.0		 5l5fV-5loyA:
23.14
5l5fW-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.85A 5l5zH-5loyA:
7.4
5l5zI-5loyA:
21.0		 5l5zH-5loyA:
23.14
5l5zI-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.84A 5l5zV-5loyA:
6.2
5l5zW-5loyA:
21.0		 5l5zV-5loyA:
23.14
5l5zW-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.83A 5l66H-5loyA:
7.4
5l66I-5loyA:
21.1		 5l66H-5loyA:
23.14
5l66I-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.83A 5l66V-5loyA:
6.1
5l66W-5loyA:
21.0		 5l66V-5loyA:
23.14
5l66W-5loyA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_V_BO2V303_1
(PROTEASOME SUBUNIT
BETA TYPE-7
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 10 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.79A 5lf3V-5loyA:
20.5
5lf3W-5loyA:
21.0		 5lf3V-5loyA:
26.44
5lf3W-5loyA:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 ILE A  44
ALA A  76
LEU A  62
ILE A 128
THR A  75
 None
 1.28A 5z6fA-5loyA:
undetectable		 5z6fA-5loyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 12 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.81A 6hwdH-5loyA:
4.6
6hwdI-5loyA:
20.9		 6hwdH-5loyA:
21.26
6hwdI-5loyA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 5loy DESIGNED ANBU
PROTEIN
(synthetic
construct) 		5 / 11 THR A   1
LYS A  32
ALA A  49
GLY A  50
THR A  55
 None
 0.81A 6hwdV-5loyA:
6.1		 6hwdV-5loyA:
21.26