SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5loz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZW9_A_SAMA801_1 (LEUCINE CARBOXYL METHYLTRANSFERASE 2)	5loz	EPSIN-1 (Saccharomyces cerevisiae)	4 / 8	THR A 130 LEU A 77 ASP A 60 GLU A 107	None	1.07A	2zw9A-5lozA: undetectable	2zw9A-5lozA: 12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G24_A_ACAA1004_1 (PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN AT2G32230, MITOCHONDRIAL)	5loz	EPSIN-1 (Saccharomyces cerevisiae)	4 / 6	ALA A 26 ASN A 25 LEU A 22 VAL A 21	None	0.88A	4g24A-5lozA: 2.7	4g24A-5lozA: 14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P65_A_IPHA101_0 (INSULIN)	5loz	EPSIN-1 (Saccharomyces cerevisiae)	5 / 10	LEU A 77 LEU A 129 ALA A 126 LEU A 99 LEU A 105	None	1.28A	4p65A-5lozA: undetectable 4p65B-5lozA: undetectable 4p65F-5lozA: undetectable 4p65H-5lozA: undetectable	4p65A-5lozA: 8.73 4p65B-5lozA: 15.38 4p65F-5lozA: 15.38 4p65H-5lozA: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QKN_A_JMSA602_1 (ALPHA-KETOGLUTARATE- DEPENDENT DIOXYGENASE FTO)	5loz	EPSIN-1 (Saccharomyces cerevisiae)	4 / 8	THR A 27 LEU A 22 VAL A 34 SER A 35	None	1.14A	4qknA-5lozA: 2.8	4qknA-5lozA: 15.32

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2ZW9_A_SAMA801_1","LEUCINE CARBOXYL METHYLTRANSFERASE 2","5loz","EPSIN-1","Saccharomyces cerevisiae",4,"THR A 130;LEU A  77;ASP A  60;GLU A 107","None","1.07A","2zw9A-5lozA:undetectable","2zw9A-5lozA:12.33"],["4G24_A_ACAA1004_1","PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN AT2G32230, MITOCHONDRIAL","5loz","EPSIN-1","Saccharomyces cerevisiae",4,"ALA A  26;ASN A  25;LEU A  22;VAL A  21","None","0.88A","4g24A-5lozA:2.7","4g24A-5lozA:14.49"],["4P65_A_IPHA101_0","INSULIN","5loz","EPSIN-1","Saccharomyces cerevisiae",5,"LEU A  77;LEU A 129;ALA A 126;LEU A  99;LEU A 105","None","1.28A","4p65A-5lozA:undetectable;4p65B-5lozA:undetectable;4p65F-5lozA:undetectable;4p65H-5lozA:undetectable","4p65A-5lozA:8.73;4p65B-5lozA:15.38;4p65F-5lozA:15.38;4p65H-5lozA:15.38"],["4QKN_A_JMSA602_1","ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO","5loz","EPSIN-1","Saccharomyces cerevisiae",4,"THR A  27;LEU A  22;VAL A  34;SER A  35","None","1.14A","4qknA-5lozA:2.8","4qknA-5lozA:15.32"]]