SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lp4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
LYS A 314
SER A 366
THR A 498
LYS A 513
GLY A 515
 None
 0.52A 1i2wA-5lp4A:
15.4		 1i2wA-5lp4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_1
(BETA-LACTAMASE
CTX-M-9)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
LYS A 314
SER A 366
THR A 498
LYS A 513
GLY A 515
 None
 0.67A 1ymxA-5lp4A:
16.4		 1ymxA-5lp4A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_2
(POL PROTEIN)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 7 ALA A 305
GLY A 406
ILE A 407
PRO A 309
 None
 0.77A 2fxdB-5lp4A:
undetectable		 2fxdB-5lp4A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA6_A_SCKA902_1
(ACETYLCHOLINESTERASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 10 ASN A 402
GLU A 192
LEU A 163
LEU A 275
TYR A 153
 None
 1.50A 2ha6A-5lp4A:
undetectable		 2ha6A-5lp4A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		3 / 3 ARG A 301
SER A 269
TYR A 307
 None
 1.05A 2q2hA-5lp4A:
undetectable
2q2hB-5lp4A:
undetectable		 2q2hA-5lp4A:
13.10
2q2hB-5lp4A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WX2_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 7 PHE A 302
ALA A 267
ALA A 159
LEU A 275
 None
 0.96A 2wx2A-5lp4A:
undetectable		 2wx2A-5lp4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 PHE A 302
PRO A 297
ALA A 267
ALA A 159
LEU A 275
 None
 0.93A 2x2nB-5lp4A:
undetectable		 2x2nB-5lp4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_C_X2NC1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 PHE A 302
PRO A 297
ALA A 267
ALA A 159
LEU A 275
 None
 0.96A 2x2nC-5lp4A:
undetectable		 2x2nC-5lp4A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 GLY A 449
ALA A 457
LEU A 456
VAL A 313
PHE A 392
 None
 1.09A 2zulA-5lp4A:
undetectable		 2zulA-5lp4A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 LEU A 588
LEU A 549
MET A 578
VAL A 256
LEU A 158
 None
 1.24A 3b0wA-5lp4A:
undetectable		 3b0wA-5lp4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		3 / 3 ARG A 364
VAL A 369
THR A 335
 None
 0.79A 3cyxA-5lp4A:
undetectable		 3cyxA-5lp4A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 GLY A 449
ALA A 457
LEU A 456
VAL A 313
PHE A 392
 None
 1.07A 3dmhA-5lp4A:
undetectable		 3dmhA-5lp4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 9 ALA A 159
LEU A 235
LEU A 442
PHE A 302
TYR A 270
 None
 1.39A 3fl9D-5lp4A:
undetectable		 3fl9D-5lp4A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 VAL A  70
GLU A  68
LEU A 103
THR A 102
GLY A 280
 None
 1.26A 3j6pB-5lp4A:
undetectable		 3j6pB-5lp4A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KHM_A_TPFA501_1
(STEROL 14
ALPHA-DEMETHYLASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 8 PHE A 302
ALA A 267
ALA A 159
LEU A 275
 None
 0.96A 3khmA-5lp4A:
undetectable		 3khmA-5lp4A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
THR A 498
LYS A 513
THR A 514
GLY A 515
 None
 0.70A 3ny4A-5lp4A:
14.8		 3ny4A-5lp4A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA308_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 366
THR A 498
LYS A 513
THR A 514
GLY A 515
THR A 516
 None
 0.84A 3ny4A-5lp4A:
14.8		 3ny4A-5lp4A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 7 PRO A 401
ILE A 191
LEU A 231
ASN A 465
 None
 0.96A 3p50A-5lp4A:
undetectable		 3p50A-5lp4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 7 PRO A 401
ILE A 191
LEU A 231
ASN A 465
 None
 0.96A 3p50B-5lp4A:
undetectable		 3p50B-5lp4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 7 PRO A 401
ILE A 191
LEU A 231
ASN A 465
 None
 0.95A 3p50C-5lp4A:
undetectable		 3p50C-5lp4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 7 PRO A 401
ILE A 191
LEU A 231
ASN A 465
 None
 0.96A 3p50D-5lp4A:
undetectable		 3p50D-5lp4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 7 PRO A 401
ILE A 191
LEU A 231
ASN A 465
 None
 0.95A 3p50E-5lp4A:
undetectable		 3p50E-5lp4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 7 GLU A 192
VAL A 166
LEU A 113
TYR A 114
 None
 0.96A 3qeoB-5lp4A:
undetectable		 3qeoB-5lp4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 11 VAL A 317
PHE A 321
ILE A 432
GLY A 433
LEU A 383
 None
 0.77A 3t3rA-5lp4A:
undetectable		 3t3rA-5lp4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		3 / 3 LYS A 361
GLU A 365
TRP A 349
 None
 1.10A 3v4tH-5lp4A:
undetectable		 3v4tH-5lp4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 11 VAL A 122
MET A 130
LEU A 137
VAL A  73
THR A 102
 None
 1.20A 4eilA-5lp4A:
undetectable		 4eilA-5lp4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 11 VAL A 122
MET A 130
LEU A 137
VAL A  73
THR A 102
 None
 1.17A 4eilC-5lp4A:
undetectable		 4eilC-5lp4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 11 VAL A 122
MET A 130
LEU A 137
VAL A  73
THR A 102
 None
 1.20A 4eilE-5lp4A:
undetectable		 4eilE-5lp4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EUZ_A_MEMA401_1
(CARBAPENEM-HYDROLIZI
NG BETA-LACTAMASE
SFC-1)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 LYS A 314
SER A 366
THR A 498
LYS A 513
THR A 514
GLY A 515
 None
 0.59A 4euzA-5lp4A:
15.7		 4euzA-5lp4A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 LEU A 322
PHE A 371
GLU A 490
THR A 498
GLY A 497
 None
 1.31A 4hvcB-5lp4A:
undetectable		 4hvcB-5lp4A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 11 VAL A 122
MET A 130
LEU A 137
VAL A  73
THR A 102
 None
 1.21A 4kyaA-5lp4A:
undetectable		 4kyaA-5lp4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 VAL A 122
MET A 130
LEU A 137
VAL A  73
THR A 102
 None
 1.26A 4kyaD-5lp4A:
undetectable		 4kyaD-5lp4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 11 VAL A 122
MET A 130
LEU A 137
VAL A  73
THR A 102
 None
 1.19A 4kyaE-5lp4A:
undetectable		 4kyaE-5lp4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_F_FOLF703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 VAL A 122
MET A 130
LEU A 137
VAL A  73
THR A 102
 None
 1.23A 4kyaF-5lp4A:
undetectable		 4kyaF-5lp4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 11 VAL A 122
MET A 130
LEU A 137
VAL A  73
THR A 102
 None
 1.20A 4kyaG-5lp4A:
undetectable		 4kyaG-5lp4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 VAL A 122
MET A 130
LEU A 137
VAL A  73
THR A 102
 None
 1.27A 4kyaH-5lp4A:
undetectable		 4kyaH-5lp4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 8 GLY A 187
GLY A 190
ILE A 191
LEU A 400
 None
 0.66A 4mwzB-5lp4A:
undetectable		 4mwzB-5lp4A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 6 GLU A 389
THR A 386
GLN A 477
LEU A 481
 None
 1.29A 4qzuC-5lp4A:
undetectable		 4qzuC-5lp4A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 5 SER A 269
ALA A 253
HIS A 161
LEU A 299
 None
 1.32A 5dzkb-5lp4A:
undetectable
5dzkp-5lp4A:
undetectable		 5dzkb-5lp4A:
17.77
5dzkp-5lp4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 5 SER A 269
ALA A 253
HIS A 161
LEU A 299
 None
 1.29A 5dzkc-5lp4A:
undetectable
5dzkq-5lp4A:
undetectable		 5dzkc-5lp4A:
17.77
5dzkq-5lp4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 5 HIS A 542
HIS A 564
VAL A 519
ALA A 517
 None
 1.38A 5i3bB-5lp4A:
undetectable		 5i3bB-5lp4A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 LEU A 574
SER A 569
GLY A 568
GLU A 566
GLY A 565
 None
 1.35A 5o4yD-5lp4A:
undetectable
5o4yE-5lp4A:
undetectable		 5o4yD-5lp4A:
2.54
5o4yE-5lp4A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 11 LEU A 575
GLY A 568
LEU A 510
VAL A 491
ALA A 547
 None
 1.14A 5o96A-5lp4A:
undetectable
5o96B-5lp4A:
undetectable		 5o96A-5lp4A:
18.69
5o96B-5lp4A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OJ0_A_9WTA801_0
(PENICILLIN-BINDING
PROTEIN 2X)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 ARG A 347
TRP A 349
SER A 366
THR A 498
GLY A 515
THR A 516
 None
 1.05A 5oj0A-5lp4A:
30.0		 5oj0A-5lp4A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		4 / 7 SER A 579
LEU A 549
ALA A 547
THR A 448
 None
 0.90A 5te8A-5lp4A:
undetectable		 5te8A-5lp4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 8 SER A 579
LEU A 549
ALA A 547
THR A 448
ALA A 259
 None
 1.28A 5te8B-5lp4A:
undetectable		 5te8B-5lp4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 LEU A 322
PHE A 371
GLU A 490
THR A 498
GLY A 497
 None
 1.27A 5xiqD-5lp4A:
undetectable		 5xiqD-5lp4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 ALA A 517
GLY A 515
THR A 514
GLY A 567
LEU A 438
 None
 1.16A 5ybbA-5lp4A:
undetectable		 5ybbA-5lp4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_B_9F2B400_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
THR A 498
LYS A 513
THR A 514
GLY A 515
 None
 0.55A 6b5yB-5lp4A:
15.8		 6b5yB-5lp4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_D_9F2D400_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
THR A 498
LYS A 513
THR A 514
GLY A 515
 None
 0.55A 6b5yD-5lp4A:
15.9		 6b5yD-5lp4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_B_9F2B301_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
THR A 498
LYS A 513
THR A 514
GLY A 515
 None
 0.52A 6b68B-5lp4A:
15.9		 6b68B-5lp4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B68_D_9F2D400_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		5 / 12 SER A 311
SER A 366
THR A 498
LYS A 513
GLY A 515
 None
 0.63A 6b68D-5lp4A:
15.9		 6b68D-5lp4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
LYS A 513
THR A 514
GLY A 515
THR A 516
 None
 0.75A 6b69A-5lp4A:
16.1
6b69B-5lp4A:
15.9		 6b69A-5lp4A:
9.67
6b69B-5lp4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_B_9F2B301_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
THR A 498
LYS A 513
THR A 514
GLY A 515
 None
 0.53A 6b69A-5lp4A:
16.1
6b69B-5lp4A:
15.9		 6b69A-5lp4A:
9.67
6b69B-5lp4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
LYS A 513
THR A 514
GLY A 515
THR A 516
 None
 0.73A 6b69D-5lp4A:
15.8		 6b69D-5lp4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B69_D_9F2D301_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
THR A 498
LYS A 513
THR A 514
GLY A 515
 None
 0.52A 6b69D-5lp4A:
15.8		 6b69D-5lp4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_B_9F2B301_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
THR A 498
LYS A 513
THR A 514
GLY A 515
 None
 0.51A 6b6aB-5lp4A:
16.0		 6b6aB-5lp4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
LYS A 513
THR A 514
GLY A 515
THR A 516
 None
 0.83A 6b6dA-5lp4A:
15.7		 6b6dA-5lp4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6D_A_9F2A302_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
THR A 498
LYS A 513
THR A 514
GLY A 515
 None
 0.69A 6b6dA-5lp4A:
15.7		 6b6dA-5lp4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
LYS A 513
THR A 514
GLY A 515
THR A 516
 None
 0.78A 6b6eA-5lp4A:
15.9		 6b6eA-5lp4A:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6E_A_9F2A302_1
(BETA-LACTAMASE)		 5lp4 PENICILLIN-BINDING
PROTEIN 2 (PBP2)
(Helicobacter
pylori) 		6 / 12 SER A 311
SER A 366
THR A 498
LYS A 513
THR A 514
GLY A 515
 None
 0.55A 6b6eA-5lp4A:
15.9		 6b6eA-5lp4A:
9.67