SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lp5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)
(Helicobacter
pylori) 		4 / 6 ALA C 225
SER C 224
ILE C 170
ASP C 181
 None
 1.04A 1yc2A-5lp5C:
undetectable		 1yc2A-5lp5C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)
(Helicobacter
pylori) 		5 / 11 SER C 111
LEU C 243
SER C 113
LEU C 114
LEU C 120
 None
 1.09A 2xn5A-5lp5C:
undetectable		 2xn5A-5lp5C:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)
(Helicobacter
pylori) 		5 / 10 LEU C 128
ALA C 156
VAL C 159
VAL C 195
THR C 197
 None
 1.27A 3r9cA-5lp5C:
undetectable		 3r9cA-5lp5C:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)
(Helicobacter
pylori) 		5 / 12 LEU C 227
VAL C 180
PHE C 169
ILE C 125
VAL C 210
 None
 1.30A 3sp9B-5lp5C:
undetectable		 3sp9B-5lp5C:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)
(Helicobacter
pylori) 		4 / 7 PHE C 204
ILE C 203
GLY C 136
LEU C 114
 None
 0.89A 4zdzA-5lp5C:
undetectable		 4zdzA-5lp5C:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)
(Helicobacter
pylori) 		4 / 7 PHE C 204
ILE C 203
GLY C 136
LEU C 114
 None
 0.89A 4ze3A-5lp5C:
undetectable		 4ze3A-5lp5C:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)
(Helicobacter
pylori) 		5 / 12 LEU C 120
GLY C 143
LEU C 243
LEU C 128
LEU C 114
 None
 1.14A 5nfjB-5lp5C:
undetectable		 5nfjB-5lp5C:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)
(Helicobacter
pylori) 		5 / 12 LEU C 120
GLY C 143
LEU C 243
LEU C 128
LEU C 114
 None
 1.13A 5nfjC-5lp5C:
undetectable		 5nfjC-5lp5C:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5lp5 ROD
SHAPE-DETERMINING
PROTEIN (MREC)
(Helicobacter
pylori) 		4 / 7 VAL C 213
ILE C 216
VAL C 180
ALA C 225
 None
 0.70A 5osrA-5lp5C:
undetectable		 5osrA-5lp5C:
21.51