SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lp8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_A_H4BA700_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 1d1vA-5lp8B:
undetectable
1d1vB-5lp8B:
undetectable		 1d1vA-5lp8B:
21.27
1d1vB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_B_H4BB701_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.28A 1d1vA-5lp8B:
undetectable
1d1vB-5lp8B:
undetectable		 1d1vA-5lp8B:
21.27
1d1vB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.27A 1d1wA-5lp8B:
undetectable
1d1wB-5lp8B:
undetectable		 1d1wA-5lp8B:
21.27
1d1wB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1X_A_H4BA600_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME DOMAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 1d1xA-5lp8B:
undetectable
1d1xB-5lp8B:
undetectable		 1d1xA-5lp8B:
21.27
1d1xB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_A_H4BA1600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.26A 1dm8A-5lp8B:
undetectable
1dm8B-5lp8B:
undetectable		 1dm8A-5lp8B:
21.27
1dm8B-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOP_A_H4BA1600_1
(NITRIC-OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.19A 1fopA-5lp8B:
undetectable
1fopB-5lp8B:
undetectable		 1fopA-5lp8B:
21.27
1fopB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.28A 1nseA-5lp8B:
undetectable
1nseB-5lp8B:
undetectable		 1nseA-5lp8B:
21.27
1nseB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 1nseA-5lp8B:
undetectable
1nseB-5lp8B:
undetectable		 1nseA-5lp8B:
21.27
1nseB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.22A 1p6lA-5lp8B:
undetectable
1p6lB-5lp8B:
undetectable		 1p6lA-5lp8B:
20.38
1p6lB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6L_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 1p6lA-5lp8B:
undetectable
1p6lB-5lp8B:
undetectable		 1p6lA-5lp8B:
20.38
1p6lB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 1p6mA-5lp8B:
undetectable
1p6mB-5lp8B:
undetectable		 1p6mA-5lp8B:
20.38
1p6mB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 1p6nA-5lp8B:
undetectable
1p6nB-5lp8B:
1.0		 1p6nA-5lp8B:
20.38
1p6nB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 1q2oA-5lp8B:
undetectable
1q2oB-5lp8B:
undetectable		 1q2oA-5lp8B:
20.38
1q2oB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q2O_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 1q2oA-5lp8B:
undetectable
1q2oB-5lp8B:
undetectable		 1q2oA-5lp8B:
20.38
1q2oB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 TYR B4078
ASN B4102
TYR B4106
LEU B4080
 None
 1.00A 1qzrA-5lp8B:
undetectable		 1qzrA-5lp8B:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4128
TYR B4133
THR B4090
TYR B4127
 None
 1.22A 1rmtB-5lp8B:
undetectable		 1rmtB-5lp8B:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 1rs8A-5lp8B:
undetectable
1rs8B-5lp8B:
undetectable		 1rs8A-5lp8B:
20.38
1rs8B-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 1rs9A-5lp8B:
undetectable
1rs9B-5lp8B:
undetectable		 1rs9A-5lp8B:
20.38
1rs9B-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 1rs9A-5lp8B:
undetectable
1rs9B-5lp8B:
undetectable		 1rs9A-5lp8B:
20.38
1rs9B-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 5 PHE B4132
PHE B4081
MET B4073
SER B4070
 None
 1.37A 1wrkB-5lp8B:
undetectable		 1wrkB-5lp8B:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 1zzrA-5lp8B:
undetectable
1zzrB-5lp8B:
undetectable		 1zzrA-5lp8B:
20.65
1zzrB-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 1zzsA-5lp8B:
undetectable
1zzsB-5lp8B:
undetectable		 1zzsA-5lp8B:
20.38
1zzsB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZS_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 1zzsA-5lp8B:
undetectable
1zzsB-5lp8B:
undetectable		 1zzsA-5lp8B:
20.38
1zzsB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 1zzuA-5lp8B:
undetectable
1zzuB-5lp8B:
undetectable		 1zzuA-5lp8B:
20.65
1zzuB-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 2hx2A-5lp8B:
undetectable
2hx2B-5lp8B:
undetectable		 2hx2A-5lp8B:
20.38
2hx2B-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 2hx2A-5lp8B:
undetectable
2hx2B-5lp8B:
undetectable		 2hx2A-5lp8B:
20.38
2hx2B-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.27A 2nseA-5lp8B:
undetectable
2nseB-5lp8B:
undetectable		 2nseA-5lp8B:
21.27
2nseB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 ARG B3971
ASP B4289
GLN B4298
GLU B4246
 None
 1.46A 2ya7C-5lp8B:
undetectable		 2ya7C-5lp8B:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 TYR B4133
PHE B4128
PHE B4074
ILE B4251
 None
 1.07A 2zseA-5lp8B:
undetectable		 2zseA-5lp8B:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		5 / 12 LEU B4249
PHE B4299
GLY B4302
ASN B4343
ASP B4346
 None
 1.27A 2zznA-5lp8B:
undetectable		 2zznA-5lp8B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		5 / 12 LEU B4249
PHE B4299
GLY B4302
ASN B4343
ASP B4346
 None
 1.28A 2zznB-5lp8B:
undetectable		 2zznB-5lp8B:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 3dqrA-5lp8B:
undetectable
3dqrB-5lp8B:
undetectable		 3dqrA-5lp8B:
20.65
3dqrB-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 3dqsA-5lp8B:
undetectable
3dqsB-5lp8B:
undetectable		 3dqsA-5lp8B:
20.38
3dqsB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 3dqsA-5lp8B:
undetectable
3dqsB-5lp8B:
undetectable		 3dqsA-5lp8B:
20.38
3dqsB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.22A 3dqtA-5lp8B:
undetectable
3dqtB-5lp8B:
undetectable		 3dqtA-5lp8B:
20.38
3dqtB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.27A 3dqtA-5lp8B:
undetectable
3dqtB-5lp8B:
undetectable		 3dqtA-5lp8B:
20.38
3dqtB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GVU_A_STIA1001_2
(TYROSINE-PROTEIN
KINASE ABL2)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 5 VAL B4110
ILE B4069
TYR B4047
MET B4017
 None
 1.38A 3gvuA-5lp8B:
undetectable		 3gvuA-5lp8B:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 LEU B4008
GLN B4003
LEU B4005
GLU B4004
 None
 1.10A 3h5gB-5lp8B:
undetectable
3h5gC-5lp8B:
undetectable		 3h5gB-5lp8B:
5.79
3h5gC-5lp8B:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 3jwxA-5lp8B:
undetectable
3jwxB-5lp8B:
undetectable		 3jwxA-5lp8B:
21.27
3jwxB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.27A 3jwxA-5lp8B:
undetectable
3jwxB-5lp8B:
undetectable		 3jwxA-5lp8B:
21.27
3jwxB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 3jwyA-5lp8B:
undetectable
3jwyB-5lp8B:
undetectable		 3jwyA-5lp8B:
21.27
3jwyB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 3jwyA-5lp8B:
undetectable
3jwyB-5lp8B:
undetectable		 3jwyA-5lp8B:
21.27
3jwyB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 3jwzA-5lp8B:
undetectable
3jwzB-5lp8B:
undetectable		 3jwzA-5lp8B:
21.27
3jwzB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.21A 3jwzA-5lp8B:
undetectable
3jwzB-5lp8B:
undetectable		 3jwzA-5lp8B:
21.27
3jwzB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 3jx2A-5lp8B:
undetectable
3jx2B-5lp8B:
undetectable		 3jx2A-5lp8B:
20.65
3jx2B-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.28A 3jx3A-5lp8B:
undetectable
3jx3B-5lp8B:
undetectable		 3jx3A-5lp8B:
20.65
3jx3B-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		3 / 3 ASP B3995
ARG B3998
ARG B3963
 None
 1.00A 3k37A-5lp8B:
undetectable		 3k37A-5lp8B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5Q_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.21A 3n5qA-5lp8B:
undetectable
3n5qB-5lp8B:
undetectable		 3n5qA-5lp8B:
21.27
3n5qB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.22A 3n5rA-5lp8B:
undetectable
3n5rB-5lp8B:
undetectable		 3n5rA-5lp8B:
21.27
3n5rB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 3n5rA-5lp8B:
undetectable
3n5rB-5lp8B:
undetectable		 3n5rA-5lp8B:
21.27
3n5rB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.22A 3n5sA-5lp8B:
undetectable
3n5sB-5lp8B:
undetectable		 3n5sA-5lp8B:
21.27
3n5sB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5S_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 3n5sA-5lp8B:
undetectable
3n5sB-5lp8B:
undetectable		 3n5sA-5lp8B:
21.27
3n5sB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.21A 3n5tA-5lp8B:
0.0
3n5tB-5lp8B:
undetectable		 3n5tA-5lp8B:
21.27
3n5tB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.21A 3n5tA-5lp8B:
0.7
3n5tB-5lp8B:
undetectable		 3n5tA-5lp8B:
21.27
3n5tB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.26A 3n61A-5lp8B:
undetectable
3n61B-5lp8B:
undetectable		 3n61A-5lp8B:
20.65
3n61B-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 3n6eA-5lp8B:
undetectable
3n6eB-5lp8B:
undetectable		 3n6eA-5lp8B:
21.27
3n6eB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6E_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 3n6eA-5lp8B:
undetectable
3n6eB-5lp8B:
undetectable		 3n6eA-5lp8B:
21.27
3n6eB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_A_H4BA600_1
('NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 3n6fA-5lp8B:
undetectable
3n6fB-5lp8B:
undetectable		 3n6fA-5lp8B:
21.27
3n6fB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6F_B_H4BB600_1
('NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 3n6fA-5lp8B:
undetectable
3n6fB-5lp8B:
undetectable		 3n6fA-5lp8B:
21.27
3n6fB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 3n6gA-5lp8B:
undetectable
3n6gB-5lp8B:
undetectable		 3n6gA-5lp8B:
21.27
3n6gB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N6G_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.21A 3n6gA-5lp8B:
undetectable
3n6gB-5lp8B:
undetectable		 3n6gA-5lp8B:
21.27
3n6gB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLD_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.19A 3nldA-5lp8B:
undetectable
3nldB-5lp8B:
0.9		 3nldA-5lp8B:
21.27
3nldB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 3nleA-5lp8B:
undetectable
3nleB-5lp8B:
undetectable		 3nleA-5lp8B:
21.27
3nleB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 3nlgA-5lp8B:
undetectable
3nlgB-5lp8B:
undetectable		 3nlgA-5lp8B:
21.27
3nlgB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 3nlgA-5lp8B:
undetectable
3nlgB-5lp8B:
undetectable		 3nlgA-5lp8B:
21.27
3nlgB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLH_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.21A 3nlhA-5lp8B:
undetectable
3nlhB-5lp8B:
undetectable		 3nlhA-5lp8B:
21.27
3nlhB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLH_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 3nlhA-5lp8B:
undetectable
3nlhB-5lp8B:
undetectable		 3nlhA-5lp8B:
21.27
3nlhB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLI_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.28A 3nliA-5lp8B:
undetectable
3nliB-5lp8B:
undetectable		 3nliA-5lp8B:
21.27
3nliB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.19A 3nlpA-5lp8B:
undetectable
3nlpB-5lp8B:
undetectable		 3nlpA-5lp8B:
20.65
3nlpB-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.26A 3nlrA-5lp8B:
undetectable
3nlrB-5lp8B:
undetectable		 3nlrA-5lp8B:
20.65
3nlrB-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLU_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 3nluA-5lp8B:
undetectable
3nluB-5lp8B:
undetectable		 3nluA-5lp8B:
21.27
3nluB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_A_H4BA511_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.28A 3nosA-5lp8B:
undetectable
3nosB-5lp8B:
undetectable		 3nosA-5lp8B:
19.96
3nosB-5lp8B:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_B_H4BB1011_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.26A 3nosA-5lp8B:
undetectable
3nosB-5lp8B:
undetectable		 3nosA-5lp8B:
19.96
3nosB-5lp8B:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 ILE B4364
LEU B4347
THR B4266
ARG B4283
 None
 1.06A 3nxuA-5lp8B:
undetectable		 3nxuA-5lp8B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNH_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.28A 3pnhA-5lp8B:
undetectable
3pnhB-5lp8B:
undetectable		 3pnhA-5lp8B:
20.38
3pnhB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PNH_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.28A 3pnhA-5lp8B:
undetectable
3pnhB-5lp8B:
undetectable		 3pnhA-5lp8B:
20.38
3pnhB-5lp8B:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 5 TYR B4091
THR B4092
PHE B4132
LEU B4080
 None
 1.46A 3qelC-5lp8B:
undetectable		 3qelC-5lp8B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQP_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 3rqpA-5lp8B:
undetectable
3rqpB-5lp8B:
undetectable		 3rqpA-5lp8B:
21.31
3rqpB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 4c3aA-5lp8B:
undetectable
4c3aB-5lp8B:
undetectable		 4c3aA-5lp8B:
21.31
4c3aB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 4c3aA-5lp8B:
undetectable
4c3aB-5lp8B:
undetectable		 4c3aA-5lp8B:
21.31
4c3aB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 4carA-5lp8B:
undetectable
4carB-5lp8B:
undetectable		 4carA-5lp8B:
21.31
4carB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.21A 4carA-5lp8B:
undetectable
4carB-5lp8B:
undetectable		 4carA-5lp8B:
21.31
4carB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 4cftA-5lp8B:
undetectable
4cftB-5lp8B:
undetectable		 4cftA-5lp8B:
21.31
4cftB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 4cftA-5lp8B:
undetectable
4cftB-5lp8B:
undetectable		 4cftA-5lp8B:
21.31
4cftB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.26A 4ctyA-5lp8B:
undetectable
4ctyB-5lp8B:
undetectable		 4ctyA-5lp8B:
21.31
4ctyB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 4ctzA-5lp8B:
undetectable
4ctzB-5lp8B:
undetectable		 4ctzA-5lp8B:
21.31
4ctzB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 4ctzA-5lp8B:
undetectable
4ctzB-5lp8B:
undetectable		 4ctzA-5lp8B:
21.31
4ctzB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 4cu0A-5lp8B:
undetectable
4cu0B-5lp8B:
undetectable		 4cu0A-5lp8B:
21.31
4cu0B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 4cu0A-5lp8B:
undetectable
4cu0B-5lp8B:
undetectable		 4cu0A-5lp8B:
21.31
4cu0B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.26A 4cu1A-5lp8B:
undetectable
4cu1B-5lp8B:
undetectable		 4cu1A-5lp8B:
21.31
4cu1B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 4cu1A-5lp8B:
undetectable
4cu1B-5lp8B:
undetectable		 4cu1A-5lp8B:
21.31
4cu1B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.26A 4cwvA-5lp8B:
undetectable
4cwvB-5lp8B:
undetectable		 4cwvA-5lp8B:
21.31
4cwvB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.26A 4cwwA-5lp8B:
undetectable
4cwwB-5lp8B:
undetectable		 4cwwA-5lp8B:
21.31
4cwwB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.26A 4cwwA-5lp8B:
undetectable
4cwwB-5lp8B:
undetectable		 4cwwA-5lp8B:
21.31
4cwwB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.27A 4cwxA-5lp8B:
undetectable
4cwxB-5lp8B:
undetectable		 4cwxA-5lp8B:
21.31
4cwxB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.26A 4cwxA-5lp8B:
undetectable
4cwxB-5lp8B:
undetectable		 4cwxA-5lp8B:
21.31
4cwxB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.26A 4cwyA-5lp8B:
undetectable
4cwyB-5lp8B:
undetectable		 4cwyA-5lp8B:
21.31
4cwyB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 4cwyA-5lp8B:
undetectable
4cwyB-5lp8B:
undetectable		 4cwyA-5lp8B:
21.31
4cwyB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 4cwzA-5lp8B:
undetectable
4cwzB-5lp8B:
undetectable		 4cwzA-5lp8B:
21.31
4cwzB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 4cwzA-5lp8B:
undetectable
4cwzB-5lp8B:
undetectable		 4cwzA-5lp8B:
21.31
4cwzB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 4cx0A-5lp8B:
undetectable
4cx0B-5lp8B:
undetectable		 4cx0A-5lp8B:
21.31
4cx0B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX0_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 4cx0A-5lp8B:
undetectable
4cx0B-5lp8B:
undetectable		 4cx0A-5lp8B:
21.31
4cx0B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.29A 4cx3A-5lp8B:
undetectable
4cx3B-5lp8B:
undetectable		 4cx3A-5lp8B:
20.65
4cx3B-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.27A 4cx3A-5lp8B:
undetectable
4cx3B-5lp8B:
undetectable		 4cx3A-5lp8B:
20.65
4cx3B-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.27A 4cx4A-5lp8B:
undetectable
4cx4B-5lp8B:
undetectable		 4cx4A-5lp8B:
20.65
4cx4B-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_A_H4BA1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.26A 4d1oA-5lp8B:
undetectable
4d1oB-5lp8B:
undetectable		 4d1oA-5lp8B:
22.42
4d1oB-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_B_H4BB1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 4d1oA-5lp8B:
undetectable
4d1oB-5lp8B:
undetectable		 4d1oA-5lp8B:
22.42
4d1oB-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1P_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 4d1pA-5lp8B:
undetectable
4d1pB-5lp8B:
undetectable		 4d1pA-5lp8B:
22.42
4d1pB-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 4d33A-5lp8B:
undetectable
4d33B-5lp8B:
undetectable		 4d33A-5lp8B:
21.31
4d33B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 4d33A-5lp8B:
undetectable
4d33B-5lp8B:
undetectable		 4d33A-5lp8B:
21.31
4d33B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.20A 4d34A-5lp8B:
undetectable
4d34B-5lp8B:
undetectable		 4d34A-5lp8B:
21.31
4d34B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.21A 4d34A-5lp8B:
undetectable
4d34B-5lp8B:
undetectable		 4d34A-5lp8B:
21.31
4d34B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.26A 4d35A-5lp8B:
undetectable
4d35B-5lp8B:
undetectable		 4d35A-5lp8B:
21.31
4d35B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.26A 4d35A-5lp8B:
undetectable
4d35B-5lp8B:
undetectable		 4d35A-5lp8B:
21.31
4d35B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 4d36A-5lp8B:
undetectable
4d36B-5lp8B:
undetectable		 4d36A-5lp8B:
21.31
4d36B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 4d36A-5lp8B:
undetectable
4d36B-5lp8B:
undetectable		 4d36A-5lp8B:
21.31
4d36B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 4d37A-5lp8B:
undetectable
4d37B-5lp8B:
undetectable		 4d37A-5lp8B:
21.31
4d37B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.22A 4d38A-5lp8B:
undetectable
4d38B-5lp8B:
undetectable		 4d38A-5lp8B:
21.31
4d38B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.26A 4d38A-5lp8B:
undetectable
4d38B-5lp8B:
undetectable		 4d38A-5lp8B:
21.31
4d38B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 4d39A-5lp8B:
undetectable
4d39B-5lp8B:
undetectable		 4d39A-5lp8B:
21.31
4d39B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.26A 4d39A-5lp8B:
undetectable
4d39B-5lp8B:
undetectable		 4d39A-5lp8B:
21.31
4d39B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.20A 4d3aA-5lp8B:
undetectable
4d3aB-5lp8B:
undetectable		 4d3aA-5lp8B:
21.31
4d3aB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.21A 4d3aA-5lp8B:
undetectable
4d3aB-5lp8B:
undetectable		 4d3aA-5lp8B:
21.31
4d3aB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_A_H4BA502_1
(SUBUNIT A)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 4imxA-5lp8B:
undetectable
4imxB-5lp8B:
undetectable		 4imxA-5lp8B:
21.36
4imxB-5lp8B:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_B_H4BB502_1
(SUBUNIT A)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.28A 4imxA-5lp8B:
undetectable
4imxB-5lp8B:
undetectable		 4imxA-5lp8B:
21.36
4imxB-5lp8B:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSK_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 4jskA-5lp8B:
undetectable
4jskB-5lp8B:
undetectable		 4jskA-5lp8B:
21.31
4jskB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSL_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 4jslA-5lp8B:
undetectable
4jslB-5lp8B:
undetectable		 4jslA-5lp8B:
21.31
4jslB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSL_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 4jslA-5lp8B:
undetectable
4jslB-5lp8B:
undetectable		 4jslA-5lp8B:
21.31
4jslB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 4jsmA-5lp8B:
undetectable
4jsmB-5lp8B:
undetectable		 4jsmA-5lp8B:
21.31
4jsmB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.26A 4jsmA-5lp8B:
undetectable
4jsmB-5lp8B:
undetectable		 4jsmA-5lp8B:
21.31
4jsmB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 4k5hA-5lp8B:
undetectable
4k5hB-5lp8B:
undetectable		 4k5hA-5lp8B:
21.31
4k5hB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 4k5hA-5lp8B:
undetectable
4k5hB-5lp8B:
undetectable		 4k5hA-5lp8B:
21.31
4k5hB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 4k5iA-5lp8B:
undetectable
4k5iB-5lp8B:
undetectable		 4k5iA-5lp8B:
21.31
4k5iB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5I_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 4k5iA-5lp8B:
undetectable
4k5iB-5lp8B:
undetectable		 4k5iA-5lp8B:
21.31
4k5iB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.21A 4k5jA-5lp8B:
undetectable
4k5jB-5lp8B:
undetectable		 4k5jA-5lp8B:
21.31
4k5jB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 4k5jA-5lp8B:
undetectable
4k5jB-5lp8B:
undetectable		 4k5jA-5lp8B:
21.31
4k5jB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.27A 4k5kA-5lp8B:
undetectable
4k5kB-5lp8B:
undetectable		 4k5kA-5lp8B:
21.31
4k5kB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 4k5kA-5lp8B:
undetectable
4k5kB-5lp8B:
undetectable		 4k5kA-5lp8B:
21.31
4k5kB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.27A 4kcpA-5lp8B:
undetectable
4kcpB-5lp8B:
undetectable		 4kcpA-5lp8B:
21.31
4kcpB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.21A 4kcpA-5lp8B:
undetectable
4kcpB-5lp8B:
undetectable		 4kcpA-5lp8B:
21.31
4kcpB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 4kcqA-5lp8B:
undetectable
4kcqB-5lp8B:
undetectable		 4kcqA-5lp8B:
21.31
4kcqB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 4kcqA-5lp8B:
undetectable
4kcqB-5lp8B:
undetectable		 4kcqA-5lp8B:
21.31
4kcqB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 4kcrA-5lp8B:
undetectable
4kcrB-5lp8B:
undetectable		 4kcrA-5lp8B:
21.31
4kcrB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 4kcrA-5lp8B:
undetectable
4kcrB-5lp8B:
undetectable		 4kcrA-5lp8B:
21.31
4kcrB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 4kcsA-5lp8B:
undetectable
4kcsB-5lp8B:
undetectable		 4kcsA-5lp8B:
21.31
4kcsB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.21A 4kcsA-5lp8B:
undetectable
4kcsB-5lp8B:
undetectable		 4kcsA-5lp8B:
21.31
4kcsB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 4luwA-5lp8B:
undetectable
4luwB-5lp8B:
undetectable		 4luwA-5lp8B:
21.04
4luwB-5lp8B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.27A 4luwA-5lp8B:
undetectable
4luwB-5lp8B:
undetectable		 4luwA-5lp8B:
21.04
4luwB-5lp8B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 ASN B4102
TYR B4078
LEU B4080
PHE B4027
 None
 1.29A 4twdB-5lp8B:
undetectable
4twdC-5lp8B:
undetectable		 4twdB-5lp8B:
22.76
4twdC-5lp8B:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 ASN B4102
TYR B4078
LEU B4080
PHE B4027
 None
 1.27A 4twdD-5lp8B:
undetectable
4twdE-5lp8B:
undetectable		 4twdD-5lp8B:
22.76
4twdE-5lp8B:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.22A 4uh7A-5lp8B:
undetectable
4uh7B-5lp8B:
undetectable		 4uh7A-5lp8B:
21.31
4uh7B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 4uh7A-5lp8B:
undetectable
4uh7B-5lp8B:
undetectable		 4uh7A-5lp8B:
21.31
4uh7B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.21A 4uh8A-5lp8B:
undetectable
4uh8B-5lp8B:
undetectable		 4uh8A-5lp8B:
21.31
4uh8B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 4uh8A-5lp8B:
undetectable
4uh8B-5lp8B:
undetectable		 4uh8A-5lp8B:
21.31
4uh8B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.21A 4uh9A-5lp8B:
undetectable
4uh9B-5lp8B:
undetectable		 4uh9A-5lp8B:
21.31
4uh9B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 4uh9A-5lp8B:
undetectable
4uh9B-5lp8B:
undetectable		 4uh9A-5lp8B:
21.31
4uh9B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 4uhaA-5lp8B:
undetectable
4uhaB-5lp8B:
undetectable		 4uhaA-5lp8B:
21.31
4uhaB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 4uhaA-5lp8B:
undetectable
4uhaB-5lp8B:
undetectable		 4uhaA-5lp8B:
21.31
4uhaB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 4upqA-5lp8B:
undetectable
4upqB-5lp8B:
undetectable		 4upqA-5lp8B:
21.31
4upqB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 4upqA-5lp8B:
undetectable
4upqB-5lp8B:
undetectable		 4upqA-5lp8B:
21.31
4upqB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 4uprA-5lp8B:
undetectable
4uprB-5lp8B:
undetectable		 4uprA-5lp8B:
21.31
4uprB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 4uprA-5lp8B:
undetectable
4uprB-5lp8B:
undetectable		 4uprA-5lp8B:
21.31
4uprB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPS_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 4upsA-5lp8B:
undetectable
4upsB-5lp8B:
undetectable		 4upsA-5lp8B:
21.31
4upsB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPS_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 4upsA-5lp8B:
undetectable
4upsB-5lp8B:
undetectable		 4upsA-5lp8B:
21.31
4upsB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 4uptA-5lp8B:
undetectable
4uptB-5lp8B:
undetectable		 4uptA-5lp8B:
21.31
4uptB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPT_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 4uptA-5lp8B:
undetectable
4uptB-5lp8B:
undetectable		 4uptA-5lp8B:
21.31
4uptB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 5addA-5lp8B:
undetectable
5addB-5lp8B:
undetectable		 5addA-5lp8B:
20.65
5addB-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.20A 5adjA-5lp8B:
undetectable
5adjB-5lp8B:
undetectable		 5adjA-5lp8B:
21.31
5adjB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.26A 5adjA-5lp8B:
undetectable
5adjB-5lp8B:
undetectable		 5adjA-5lp8B:
21.31
5adjB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 5adkA-5lp8B:
undetectable
5adkB-5lp8B:
undetectable		 5adkA-5lp8B:
21.31
5adkB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 5adkA-5lp8B:
undetectable
5adkB-5lp8B:
undetectable		 5adkA-5lp8B:
21.31
5adkB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.22A 5adlA-5lp8B:
undetectable
5adlB-5lp8B:
undetectable		 5adlA-5lp8B:
21.31
5adlB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 5adlA-5lp8B:
undetectable
5adlB-5lp8B:
undetectable		 5adlA-5lp8B:
21.31
5adlB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.22A 5admA-5lp8B:
undetectable
5admB-5lp8B:
undetectable		 5admA-5lp8B:
21.31
5admB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 5admA-5lp8B:
undetectable
5admB-5lp8B:
undetectable		 5admA-5lp8B:
21.31
5admB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 5adnA-5lp8B:
undetectable
5adnB-5lp8B:
undetectable		 5adnA-5lp8B:
21.31
5adnB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 5adnA-5lp8B:
undetectable
5adnB-5lp8B:
undetectable		 5adnA-5lp8B:
21.31
5adnB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.21A 5fj2A-5lp8B:
undetectable
5fj2B-5lp8B:
undetectable		 5fj2A-5lp8B:
21.31
5fj2B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 5fj2A-5lp8B:
undetectable
5fj2B-5lp8B:
undetectable		 5fj2A-5lp8B:
21.31
5fj2B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 5fj3A-5lp8B:
undetectable
5fj3B-5lp8B:
undetectable		 5fj3A-5lp8B:
21.31
5fj3B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 5fj3A-5lp8B:
undetectable
5fj3B-5lp8B:
undetectable		 5fj3A-5lp8B:
21.31
5fj3B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.20A 5fvyA-5lp8B:
undetectable
5fvyB-5lp8B:
undetectable		 5fvyA-5lp8B:
21.31
5fvyB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 5fvyA-5lp8B:
undetectable
5fvyB-5lp8B:
undetectable		 5fvyA-5lp8B:
21.31
5fvyB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.21A 5fvzA-5lp8B:
undetectable
5fvzB-5lp8B:
0.9		 5fvzA-5lp8B:
21.31
5fvzB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVZ_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.21A 5fvzA-5lp8B:
undetectable
5fvzB-5lp8B:
0.9		 5fvzA-5lp8B:
21.31
5fvzB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 5g0pA-5lp8B:
undetectable
5g0pB-5lp8B:
undetectable		 5g0pA-5lp8B:
20.65
5g0pB-5lp8B:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		3 / 3 ILE B4234
PRO B4235
ILE B4239
 None
 0.46A 5hw8F-5lp8B:
undetectable		 5hw8F-5lp8B:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.26A 5uo8A-5lp8B:
undetectable
5uo8B-5lp8B:
undetectable		 5uo8A-5lp8B:
22.42
5uo8B-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.22A 5uo8C-5lp8B:
undetectable
5uo8D-5lp8B:
0.0		 5uo8C-5lp8B:
22.42
5uo8D-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.19A 5uo8C-5lp8B:
undetectable
5uo8D-5lp8B:
0.0		 5uo8C-5lp8B:
22.42
5uo8D-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.31A 5uo9A-5lp8B:
0.0
5uo9B-5lp8B:
0.0		 5uo9A-5lp8B:
22.42
5uo9B-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 5uo9A-5lp8B:
undetectable
5uo9B-5lp8B:
undetectable		 5uo9A-5lp8B:
22.42
5uo9B-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.28A 5uo9C-5lp8B:
undetectable
5uo9D-5lp8B:
0.0		 5uo9C-5lp8B:
22.42
5uo9D-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.19A 5uo9C-5lp8B:
undetectable
5uo9D-5lp8B:
undetectable		 5uo9C-5lp8B:
22.42
5uo9D-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.26A 5uodA-5lp8B:
undetectable
5uodB-5lp8B:
undetectable		 5uodA-5lp8B:
21.31
5uodB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 5uodA-5lp8B:
undetectable
5uodB-5lp8B:
undetectable		 5uodA-5lp8B:
21.31
5uodB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 5vv6A-5lp8B:
undetectable
5vv6B-5lp8B:
undetectable		 5vv6A-5lp8B:
21.31
5vv6B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 5vv6A-5lp8B:
undetectable
5vv6B-5lp8B:
undetectable		 5vv6A-5lp8B:
21.31
5vv6B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 5vv7A-5lp8B:
undetectable
5vv7B-5lp8B:
undetectable		 5vv7A-5lp8B:
21.31
5vv7B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.23A 5vv7A-5lp8B:
undetectable
5vv7B-5lp8B:
undetectable		 5vv7A-5lp8B:
21.31
5vv7B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 5vv8A-5lp8B:
undetectable
5vv8B-5lp8B:
undetectable		 5vv8A-5lp8B:
21.31
5vv8B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 5vv8A-5lp8B:
undetectable
5vv8B-5lp8B:
undetectable		 5vv8A-5lp8B:
21.31
5vv8B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.27A 5vv9A-5lp8B:
undetectable
5vv9B-5lp8B:
undetectable		 5vv9A-5lp8B:
21.31
5vv9B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 5vv9A-5lp8B:
undetectable
5vv9B-5lp8B:
undetectable		 5vv9A-5lp8B:
21.31
5vv9B-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.26A 5vvaA-5lp8B:
undetectable
5vvaB-5lp8B:
undetectable		 5vvaA-5lp8B:
21.31
5vvaB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.26A 5vvaA-5lp8B:
undetectable
5vvaB-5lp8B:
undetectable		 5vvaA-5lp8B:
21.31
5vvaB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.19A 5vvbA-5lp8B:
undetectable
5vvbB-5lp8B:
0.0		 5vvbA-5lp8B:
22.42
5vvbB-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.24A 5vvbC-5lp8B:
0.0
5vvbD-5lp8B:
undetectable		 5vvbC-5lp8B:
22.42
5vvbD-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.28A 5vvcA-5lp8B:
0.0
5vvcB-5lp8B:
undetectable		 5vvcA-5lp8B:
22.42
5vvcB-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.22A 5vvcC-5lp8B:
0.0
5vvcD-5lp8B:
0.0		 5vvcC-5lp8B:
22.42
5vvcD-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.17A 5vvcC-5lp8B:
0.0
5vvcD-5lp8B:
0.0		 5vvcC-5lp8B:
22.42
5vvcD-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.18A 5vvdA-5lp8B:
undetectable
5vvdB-5lp8B:
undetectable		 5vvdA-5lp8B:
22.42
5vvdB-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.19A 5vvdC-5lp8B:
undetectable
5vvdD-5lp8B:
undetectable		 5vvdC-5lp8B:
22.42
5vvdD-5lp8B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 5vvgA-5lp8B:
undetectable
5vvgB-5lp8B:
undetectable		 5vvgA-5lp8B:
21.31
5vvgB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.21A 5vvgA-5lp8B:
undetectable
5vvgB-5lp8B:
undetectable		 5vvgA-5lp8B:
21.31
5vvgB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 5vvnA-5lp8B:
undetectable
5vvnB-5lp8B:
undetectable		 5vvnA-5lp8B:
21.31
5vvnB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.25A 5vvnA-5lp8B:
undetectable
5vvnB-5lp8B:
undetectable		 5vvnA-5lp8B:
21.31
5vvnB-5lp8B:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.22A 6av6A-5lp8B:
undetectable
6av6B-5lp8B:
undetectable		 6av6A-5lp8B:
10.22
6av6B-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.20A 6av6A-5lp8B:
undetectable
6av6B-5lp8B:
undetectable		 6av6A-5lp8B:
10.22
6av6B-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.21A 6av6C-5lp8B:
undetectable
6av6D-5lp8B:
0.0		 6av6C-5lp8B:
10.22
6av6D-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.18A 6av6C-5lp8B:
undetectable
6av6D-5lp8B:
undetectable		 6av6C-5lp8B:
10.22
6av6D-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.24A 6av7A-5lp8B:
undetectable
6av7B-5lp8B:
undetectable		 6av7A-5lp8B:
10.22
6av7B-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.20A 6av7A-5lp8B:
0.0
6av7B-5lp8B:
undetectable		 6av7A-5lp8B:
10.22
6av7B-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.21A 6av7C-5lp8B:
undetectable
6av7D-5lp8B:
undetectable		 6av7C-5lp8B:
10.22
6av7D-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.20A 6av7C-5lp8B:
undetectable
6av7D-5lp8B:
undetectable		 6av7C-5lp8B:
10.22
6av7D-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_A_H4BA502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.27A 6cieA-5lp8B:
undetectable
6cieB-5lp8B:
undetectable		 6cieA-5lp8B:
10.22
6cieB-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 7 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.22A 6cieA-5lp8B:
undetectable
6cieB-5lp8B:
undetectable		 6cieA-5lp8B:
10.22
6cieB-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.23A 6cieC-5lp8B:
undetectable
6cieD-5lp8B:
0.0		 6cieC-5lp8B:
10.22
6cieD-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.17A 6cieC-5lp8B:
undetectable
6cieD-5lp8B:
0.0		 6cieC-5lp8B:
10.22
6cieD-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.21A 6cifA-5lp8B:
undetectable
6cifB-5lp8B:
0.0		 6cifA-5lp8B:
10.22
6cifB-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.20A 6cifC-5lp8B:
undetectable
6cifD-5lp8B:
undetectable		 6cifC-5lp8B:
10.22
6cifD-5lp8B:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.25A 8nseA-5lp8B:
undetectable
8nseB-5lp8B:
undetectable		 8nseA-5lp8B:
21.27
8nseB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 VAL B4019
TRP B4065
PHE B4109
GLU B4033
 None
 1.28A 9nseA-5lp8B:
undetectable
9nseB-5lp8B:
undetectable		 9nseA-5lp8B:
21.27
9nseB-5lp8B:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1
(Homo
sapiens) 		4 / 6 PHE B4109
GLU B4033
VAL B4019
TRP B4065
 None
 1.28A 9nseA-5lp8B:
undetectable
9nseB-5lp8B:
undetectable		 9nseA-5lp8B:
21.27
9nseB-5lp8B:
21.27