SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lpc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		3 / 3 LEU A 268
SER A 189
ASN A 556
 None
 0.77A 1bx4A-5lpcA:
undetectable		 1bx4A-5lpcA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3002_1
(SERUM ALBUMIN)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		4 / 8 GLN A 322
ASN A 323
LEU A 135
ARG A 136
 None
 1.06A 1hk3A-5lpcA:
undetectable		 1hk3A-5lpcA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		4 / 6 ASN A 277
ASN A 276
ILE A 274
GLY A 275
 None
 1.05A 1oniA-5lpcA:
undetectable
1oniB-5lpcA:
undetectable		 1oniA-5lpcA:
12.79
1oniB-5lpcA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		4 / 6 ASN A 277
ASN A 276
ILE A 274
GLY A 275
 None
 1.08A 1oniD-5lpcA:
undetectable
1oniF-5lpcA:
undetectable		 1oniD-5lpcA:
12.79
1oniF-5lpcA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		4 / 8 ARG A 436
HIS A 513
GLU A 508
ASP A 326
 PO4  A 901 (-3.2A)
PO4  A 901 (-4.3A)
None
None
 1.02A 1s3zA-5lpcA:
undetectable
1s3zB-5lpcA:
undetectable		 1s3zA-5lpcA:
15.38
1s3zB-5lpcA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		5 / 9 LEU A 472
LEU A 182
HIS A 479
ARG A 184
LEU A 183
 None
 1.20A 2bxeA-5lpcA:
1.5		 2bxeA-5lpcA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		5 / 9 ALA A 518
ALA A 524
GLY A 525
HIS A 520
ILE A 584
 PO4  A 901 ( 4.3A)
None
None
PO4  A 901 (-4.1A)
None
 1.21A 2v7bA-5lpcA:
undetectable		 2v7bA-5lpcA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		5 / 9 ALA A 518
ALA A 524
GLY A 525
HIS A 520
ILE A 584
 PO4  A 901 ( 4.3A)
None
None
PO4  A 901 (-4.1A)
None
 1.23A 2v7bB-5lpcA:
undetectable		 2v7bB-5lpcA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		4 / 6 SER A 515
TYR A 595
VAL A 177
ASP A 598
 None
 1.37A 2x45A-5lpcA:
undetectable		 2x45A-5lpcA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		5 / 12 TYR A 632
GLY A 612
GLY A 151
ALA A  15
LEU A  18
 None
 1.10A 2zulA-5lpcA:
undetectable		 2zulA-5lpcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		5 / 12 TYR A 632
GLY A 612
GLY A 151
ALA A  15
LEU A  18
 None
 1.11A 3dmhA-5lpcA:
undetectable		 3dmhA-5lpcA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		5 / 11 ALA A 546
ILE A 551
GLY A 544
LEU A 566
LEU A 567
 None
 0.95A 3kw2A-5lpcA:
undetectable		 3kw2A-5lpcA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		5 / 10 TYR A 369
TYR A 359
SER A 585
TYR A 599
ILE A 586
 None
 1.50A 3uprA-5lpcA:
undetectable		 3uprA-5lpcA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		3 / 3 ARG A 136
TRP A 138
GLY A  55
 None
 0.91A 4e7cA-5lpcA:
undetectable		 4e7cA-5lpcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		3 / 3 TRP A 318
GLN A 483
THR A 317
 None
 0.61A 4m2xA-5lpcA:
undetectable		 4m2xA-5lpcA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2G_B_CTCB222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		5 / 12 ARG A 436
PRO A 437
VAL A 177
GLN A 180
ILE A 586
 PO4  A 901 (-3.2A)
None
None
None
None
 1.47A 4v2gB-5lpcA:
undetectable		 4v2gB-5lpcA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		5 / 11 ALA A 461
LEU A 463
LEU A 440
ARG A 164
LEU A 170
 None
 0.97A 4wg0E-5lpcA:
undetectable
4wg0F-5lpcA:
undetectable
4wg0G-5lpcA:
undetectable		 4wg0E-5lpcA:
3.85
4wg0F-5lpcA:
3.85
4wg0G-5lpcA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		5 / 8 PRO A 152
VAL A 157
GLY A 606
ALA A 526
GLY A 420
 None
 1.08A 4zjzA-5lpcA:
undetectable		 4zjzA-5lpcA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		4 / 7 HIS A 594
LYS A 428
GLY A 519
HIS A 513
 PO4  A 901 (-4.1A)
PO4  A 901 (-2.8A)
PO4  A 901 (-3.2A)
PO4  A 901 (-4.3A)
 1.14A 5a5zC-5lpcA:
undetectable		 5a5zC-5lpcA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		4 / 6 GLU A  60
ASP A 488
ARG A 489
GLY A 491
 None
 0.93A 5cdnT-5lpcA:
undetectable
5cdnU-5lpcA:
undetectable		 5cdnT-5lpcA:
21.08
5cdnU-5lpcA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		5 / 12 PHE A 255
LEU A 210
GLY A 471
VAL A 249
ILE A 254
 None
 1.23A 5tuiB-5lpcA:
undetectable		 5tuiB-5lpcA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 5lpc VANADIUM-DEPENDENT
BROMOPEROXIDASE
(Acaryochloris
marina) 		4 / 5 GLY A 517
ARG A 425
ASP A 598
GLN A 180
 None
 1.14A 5ubbA-5lpcA:
undetectable		 5ubbA-5lpcA:
15.93