SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lpe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		3 / 3 ALA A  43
VAL A  45
TRP A  29
 None
 0.76A 1av2A-5lpeA:
undetectable
1av2B-5lpeA:
undetectable		 1av2A-5lpeA:
11.25
1av2B-5lpeA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		3 / 3 TRP A  29
ALA A  43
VAL A  45
 None
 0.90A 1av2C-5lpeA:
undetectable
1av2D-5lpeA:
undetectable		 1av2C-5lpeA:
11.25
1av2D-5lpeA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD6_0
(GRAMICIDIN A)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		4 / 4 VAL A  52
TRP A  29
ALA A 120
VAL A  45
 None
 1.41A 1gmkC-5lpeA:
undetectable
1gmkD-5lpeA:
undetectable		 1gmkC-5lpeA:
11.25
1gmkD-5lpeA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		3 / 3 ALA A  43
VAL A  45
TRP A  29
 None
 0.75A 1w5uA-5lpeA:
undetectable
1w5uB-5lpeA:
undetectable		 1w5uA-5lpeA:
11.25
1w5uB-5lpeA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		3 / 3 TRP A  29
ALA A  43
VAL A  45
 None
 0.84A 1w5uA-5lpeA:
undetectable
1w5uB-5lpeA:
undetectable		 1w5uA-5lpeA:
11.25
1w5uB-5lpeA:
11.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H9T_H_SVRH301_1
(THROMBIN)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		5 / 11 HIS A  91
PRO A  92
TRP A 237
LYS A 240
VAL A 241
 None
 0.61A 2h9tH-5lpeA:
5.3		 2h9tH-5lpeA:
31.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		3 / 3 ALA A  43
VAL A  45
TRP A  29
 None
 1.00A 2izqA-5lpeA:
undetectable
2izqB-5lpeA:
undetectable		 2izqA-5lpeA:
11.25
2izqB-5lpeA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		3 / 3 TRP A  29
ALA A  43
VAL A  45
 None
 0.84A 2izqC-5lpeA:
undetectable
2izqD-5lpeA:
undetectable		 2izqC-5lpeA:
11.25
2izqD-5lpeA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		4 / 5 PRO A 198
ALA A 139
ASP A  99
ASP A 194
 None
None
ZN  A 304 (-2.5A)
None
 0.93A 2nyuB-5lpeA:
undetectable		 2nyuB-5lpeA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		5 / 12 ALA A  43
GLY A 196
GLY A 197
ALA A 139
GLY A 211
 None
 0.93A 2pkmA-5lpeA:
undetectable		 2pkmA-5lpeA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		5 / 11 HIS A  91
PRO A  92
TRP A 237
LYS A 240
VAL A 241
 None
 0.69A 3bf6H-5lpeA:
11.7		 3bf6H-5lpeA:
31.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		3 / 3 TRP A  29
ALA A  43
VAL A  45
 None
 0.86A 3l8lC-5lpeA:
undetectable
3l8lD-5lpeA:
undetectable		 3l8lC-5lpeA:
11.25
3l8lD-5lpeA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		5 / 10 VAL A  67
LEU A  46
VAL A  31
THR A  85
VAL A  52
 None
 1.06A 4e3hA-5lpeA:
undetectable		 4e3hA-5lpeA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 5lpe KALLIKREIN-10
(Homo
sapiens) 		5 / 11 VAL A 217
THR A 144
ALA A  43
THR A  54
LEU A 213
 SO4  A 301 (-4.1A)
None
None
None
None
 1.21A 6h1lB-5lpeA:
undetectable		 6h1lB-5lpeA:
18.88