SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lph'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 5lph CENTROSOMAL PROTEIN
OF 104 KDA
(Homo
sapiens) 		4 / 5 GLU A 624
ALA A 584
SER A 580
HIS A 582
 None
 1.33A 1errA-5lphA:
undetectable
1errB-5lphA:
undetectable		 1errA-5lphA:
24.50
1errB-5lphA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5lph CENTROSOMAL PROTEIN
OF 104 KDA
(Homo
sapiens) 		4 / 6 LEU A 598
VAL A 615
VAL A 572
ILE A 632
 None
 1.13A 2hyyB-5lphA:
undetectable		 2hyyB-5lphA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 5lph CENTROSOMAL PROTEIN
OF 104 KDA
(Homo
sapiens) 		4 / 7 VAL A 485
SER A 500
THR A 529
LEU A 533
 None
 1.09A 3arrA-5lphA:
undetectable		 3arrA-5lphA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lph CENTROSOMAL PROTEIN
OF 104 KDA
(Homo
sapiens) 		3 / 3 ARG A 487
LYS A 490
ARG A 486
 None
 1.10A 3w1wA-5lphA:
undetectable
3w1wB-5lphA:
undetectable		 3w1wA-5lphA:
21.81
3w1wB-5lphA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lph CENTROSOMAL PROTEIN
OF 104 KDA
(Homo
sapiens) 		3 / 3 ARG A 486
ARG A 487
LYS A 490
 None
 1.08A 3w1wA-5lphA:
undetectable
3w1wB-5lphA:
undetectable		 3w1wA-5lphA:
21.81
3w1wB-5lphA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5lph CENTROSOMAL PROTEIN
OF 104 KDA
(Homo
sapiens) 		4 / 4 ILE A 659
ASN A 658
ILE A 664
VAL A 630
 None
 1.22A 4uy87-5lphA:
undetectable		 4uy87-5lphA:
4.55