SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lpy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 ILE A 910
ALA A 900
ALA A 879
PHE A 883
CYH A 946
LEU A 871
None
1.49A 1fm6A-5lpyA:
undetectable
1fm6A-5lpyA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
4 / 7 VAL A 940
MET A 959
ARG A1008
LEU A1016
None
None
None
ATP  A1200 (-4.6A)
0.86A 1iepB-5lpyA:
22.7
1iepB-5lpyA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
4 / 7 LEU A 871
LEU A 954
MET A 928
LEU A 868
None
1.03A 1kt3A-5lpyA:
undetectable
1kt3A-5lpyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 ALA A 909
LYS A 911
GLU A 927
LEU A 954
MET A 959
GLY A 962
LEU A1016
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.53A 1m17A-5lpyA:
26.0
1m17A-5lpyA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 VAL A 897
ALA A 909
GLU A 927
VAL A 940
PHE A 958
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.63A 1opjA-5lpyA:
22.8
1opjA-5lpyA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 VAL A 897
ALA A 909
GLU A 927
VAL A 940
PHE A 958
GLY A 962
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
0.73A 1opjB-5lpyA:
22.8
1opjB-5lpyA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 11 PHE A1112
LEU A1080
ALA A1136
ALA A1134
LEU A1096
None
1.17A 1rlbF-5lpyA:
undetectable
1rlbF-5lpyA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 ILE A 889
VAL A 897
ALA A 909
GLU A 927
LEU A 997
HIS A1007
None
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
None
None
0.95A 1uwjB-5lpyA:
6.5
1uwjB-5lpyA:
30.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 ALA A 909
GLY A 962
ASP A 966
LEU A1016
ASP A1027
PHE A1028
ATP  A1200 (-3.5A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.9A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
None
1.00A 1xkkA-5lpyA:
23.0
1xkkA-5lpyA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 9 VAL A 897
LYS A 911
LEU A 942
LEU A 954
MET A 959
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.8A)
None
None
None
0.77A 1xkkA-5lpyA:
23.0
1xkkA-5lpyA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 VAL A 897
LYS A 911
VAL A 940
ASN A1014
LEU A1016
ASP A1027
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 (-3.6A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.66A 2eufB-5lpyA:
24.4
2eufB-5lpyA:
27.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 VAL A 897
ALA A 909
GLU A 927
PHE A 958
GLY A 962
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.84A 2hyyA-5lpyA:
23.1
2hyyA-5lpyA:
30.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 VAL A 897
ALA A 909
GLU A 927
VAL A 940
PHE A 958
GLY A 962
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.63A 2hyyC-5lpyA:
23.2
2hyyC-5lpyA:
30.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 ALA A 909
LYS A 911
GLU A 927
LEU A 954
GLY A 962
LEU A1016
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.51A 2itoA-5lpyA:
24.8
2itoA-5lpyA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITY_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
9 / 12 GLY A 890
VAL A 897
ALA A 909
LYS A 911
GLU A 927
LEU A 954
GLY A 962
LEU A1016
ASP A1027
ATP  A1200 ( 4.6A)
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.73A 2ityA-5lpyA:
24.6
2ityA-5lpyA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
8 / 12 VAL A 897
ALA A 909
LYS A 911
GLU A 927
GLY A 962
ASP A 966
LEU A1016
ASP A1027
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.9A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.77A 2itzA-5lpyA:
24.7
2itzA-5lpyA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 9 VAL A 897
ALA A 909
MET A 959
GLY A 962
LEU A1016
ASP A1027
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.55A 2xp2A-5lpyA:
23.5
2xp2A-5lpyA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6O_A_1N1A1892_1
(EPHRIN TYPE-A
RECEPTOR 4)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 ILE A 889
ALA A 909
LYS A 911
GLU A 927
GLY A 962
LEU A1016
SER A1026
None
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 ( 4.7A)
0.63A 2y6oA-5lpyA:
24.1
2y6oA-5lpyA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 10 ILE A 889
VAL A 897
ALA A 909
GLY A 962
ASP A 966
LEU A1016
None
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.9A)
ATP  A1200 (-4.6A)
0.78A 2y7jD-5lpyA:
25.4
2y7jD-5lpyA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 10 VAL A 897
ALA A 909
MET A 959
GLY A 962
ASP A 966
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.9A)
ATP  A1200 (-4.6A)
0.58A 2y7jD-5lpyA:
25.4
2y7jD-5lpyA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 ALA A 909
LYS A 911
GLU A 927
VAL A 940
MET A 959
GLY A 962
LEU A1016
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.62A 2zvaA-5lpyA:
25.9
2zvaA-5lpyA:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOX_A_EMHA901_1
(ALK TYROSINE KINASE
RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 10 ALA A 909
LYS A 911
VAL A 940
MET A 959
GLY A 962
LEU A1016
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.54A 3aoxA-5lpyA:
22.6
3aoxA-5lpyA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
4 / 7 VAL A1111
THR A1081
LEU A1077
TRP A 980
None
1.23A 3arrA-5lpyA:
undetectable
3arrA-5lpyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 VAL A 897
ALA A 909
LYS A 911
LEU A 954
GLY A 962
LEU A1016
PHE A1028
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
None
1.04A 3bbtD-5lpyA:
22.8
3bbtD-5lpyA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 VAL A 897
LYS A 911
LEU A 954
GLY A 962
LEU A1016
ASP A1027
PHE A1028
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
None
1.19A 3bbtD-5lpyA:
22.8
3bbtD-5lpyA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 12 ALA A 909
GLU A 927
LEU A 939
PHE A 958
GLY A 962
ATP  A1200 (-3.5A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
0.64A 3cs9D-5lpyA:
21.8
3cs9D-5lpyA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 12 ALA A 909
LEU A 939
PHE A 958
GLY A 962
HIS A1007
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
None
0.42A 3cs9D-5lpyA:
21.8
3cs9D-5lpyA:
29.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 12 ALA A 909
LEU A 939
VAL A 940
HIS A1007
LEU A1016
ATP  A1200 (-3.5A)
None
None
None
ATP  A1200 (-4.6A)
0.53A 3ik3A-5lpyA:
22.4
3ik3A-5lpyA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 12 ALA A 909
GLU A 927
LEU A 939
VAL A 940
LEU A1016
ATP  A1200 (-3.5A)
None
None
None
ATP  A1200 (-4.6A)
0.71A 3ik3B-5lpyA:
22.2
3ik3B-5lpyA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 12 ALA A 909
LEU A 939
VAL A 940
HIS A1007
LEU A1016
ATP  A1200 (-3.5A)
None
None
None
ATP  A1200 (-4.6A)
0.57A 3ik3B-5lpyA:
22.2
3ik3B-5lpyA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 VAL A 897
ALA A 909
GLU A 927
PHE A 958
GLY A 962
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.73A 3k5vA-5lpyA:
17.0
3k5vA-5lpyA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 VAL A 897
ALA A 909
GLU A 927
PHE A 958
GLY A 962
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.71A 3k5vB-5lpyA:
22.6
3k5vB-5lpyA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
4 / 8 ALA A 909
LYS A 911
LEU A 954
MET A 959
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
0.37A 3lfaA-5lpyA:
17.9
3lfaA-5lpyA:
26.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
9 / 11 ILE A 889
ALA A 909
LYS A 911
VAL A 940
PHE A 958
MET A 959
GLY A 962
LEU A1016
ASP A1027
None
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.65A 3miyA-5lpyA:
24.6
3miyA-5lpyA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
9 / 11 ILE A 889
ALA A 909
LYS A 911
VAL A 940
PHE A 958
MET A 959
GLY A 962
LEU A1016
SER A1026
None
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 ( 4.7A)
0.49A 3miyA-5lpyA:
24.6
3miyA-5lpyA:
30.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
8 / 9 ILE A 889
ALA A 909
LYS A 911
PHE A 958
MET A 959
GLY A 962
LEU A1016
SER A1026
None
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 ( 4.7A)
0.54A 3miyB-5lpyA:
24.5
3miyB-5lpyA:
30.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 VAL A 897
ALA A 909
GLU A 927
VAL A 940
GLY A 962
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.57A 3oezA-5lpyA:
22.8
3oezA-5lpyA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 ALA A 909
GLU A 927
LEU A 939
VAL A 940
GLY A 962
HIS A1007
ATP  A1200 (-3.5A)
None
None
None
ATP  A1200 ( 4.0A)
None
0.70A 3oxzA-5lpyA:
22.5
3oxzA-5lpyA:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 9 ILE A 889
ALA A 909
VAL A 940
PHE A 958
LEU A1016
None
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.76A 3ti1A-5lpyA:
20.7
3ti1A-5lpyA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 VAL A 897
ALA A 909
LYS A 911
LEU A 954
MET A 959
GLY A 962
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.63A 3ug2A-5lpyA:
25.2
3ug2A-5lpyA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 12 ALA A 909
MET A 959
GLY A 962
LEU A1016
ASP A1027
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.48A 3zbfA-5lpyA:
24.5
3zbfA-5lpyA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
8 / 12 VAL A 897
ALA A 909
LYS A 911
GLU A 927
VAL A 940
PHE A 958
GLY A 962
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.75A 4ag8A-5lpyA:
23.1
4ag8A-5lpyA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 11 ALA A 909
LYS A 911
VAL A 940
PHE A 958
GLY A 962
LEU A1016
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.71A 4agdA-5lpyA:
21.9
4agdA-5lpyA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 9 VAL A 897
ALA A 909
MET A 959
GLY A 962
LEU A1016
ASP A1027
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.61A 4anqA-5lpyA:
23.1
4anqA-5lpyA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 9 VAL A 897
ALA A 909
MET A 959
GLY A 962
LEU A1016
ASP A1027
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.65A 4ansA-5lpyA:
23.1
4ansA-5lpyA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
8 / 12 VAL A 897
ALA A 909
LYS A 911
GLU A 927
PHE A 958
GLY A 962
LEU A 997
HIS A1007
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
None
None
0.84A 4asdA-5lpyA:
22.7
4asdA-5lpyA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HJO_A_AQ4A1001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 VAL A 897
ALA A 909
LYS A 911
MET A 959
GLY A 962
LEU A1016
ASP A1027
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.85A 4hjoA-5lpyA:
23.4
4hjoA-5lpyA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
9 / 12 GLY A 890
VAL A 897
ALA A 909
LYS A 911
LEU A 954
GLY A 962
ASP A 966
LEU A1016
ASP A1027
ATP  A1200 ( 4.6A)
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.9A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.73A 4i22A-5lpyA:
22.1
4i22A-5lpyA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 10 ILE A 889
ALA A 909
VAL A 940
PHE A 958
GLY A 962
LEU A1016
SER A1026
None
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 ( 4.7A)
0.49A 4ks8A-5lpyA:
24.8
4ks8A-5lpyA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 10 ILE A 889
ALA A 909
VAL A 940
PHE A 958
LEU A1016
SER A1026
ASP A1027
None
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 ( 4.7A)
ATP  A1200 (-4.1A)
0.70A 4ks8A-5lpyA:
24.8
4ks8A-5lpyA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_A_ADNA401_1
(CYCLIN-DEPENDENT
KINASE 9)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 8 VAL A 897
ALA A 909
ASN A1014
LEU A1016
ASP A1027
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.6A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.44A 4ogrA-5lpyA:
24.9
4ogrA-5lpyA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 11 ILE A 889
ALA A 909
LYS A 911
GLU A 927
LEU A1016
ASP A1027
None
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.77A 4qmsA-5lpyA:
25.1
4qmsA-5lpyA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
8 / 12 VAL A 897
ALA A 909
LYS A 911
PHE A 958
MET A 959
GLY A 962
LEU A1016
ASP A1027
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.50A 4twpA-5lpyA:
25.9
4twpA-5lpyA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_A_AXIA601_1
(TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
8 / 12 VAL A 897
ALA A 909
PHE A 958
MET A 959
GLY A 962
ASN A1014
LEU A1016
ASP A1027
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.6A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.49A 4twpA-5lpyA:
25.9
4twpA-5lpyA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWP_B_AXIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
8 / 12 VAL A 897
ALA A 909
PHE A 958
MET A 959
GLY A 962
ASN A1014
LEU A1016
ASP A1027
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.6A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.51A 4twpB-5lpyA:
25.9
4twpB-5lpyA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 VAL A 897
ALA A 909
LYS A 911
PHE A 958
MET A 959
GLY A 962
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.63A 4wa9B-5lpyA:
24.7
4wa9B-5lpyA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA9_B_AXIB9000_1
(TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 VAL A 897
ALA A 909
PHE A 958
MET A 959
GLY A 962
ASN A1014
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.6A)
ATP  A1200 (-4.6A)
0.53A 4wa9B-5lpyA:
24.7
4wa9B-5lpyA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WKQ_A_IREA1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 ALA A 909
LYS A 911
GLU A 927
LEU A 954
GLY A 962
LEU A1016
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.54A 4wkqA-5lpyA:
26.0
4wkqA-5lpyA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_1
(TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 VAL A 897
ALA A 909
LYS A 911
VAL A 940
PHE A 958
GLY A 962
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.65A 4xeyB-5lpyA:
25.4
4xeyB-5lpyA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 9 VAL A 897
ALA A 909
MET A 959
GLY A 962
LEU A1016
ASP A1027
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.48A 5aaaA-5lpyA:
23.4
5aaaA-5lpyA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 10 VAL A 897
ALA A 909
LYS A 911
MET A 959
GLY A 962
LEU A1016
ASP A1027
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.69A 5aabA-5lpyA:
23.3
5aabA-5lpyA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 12 ASN A1014
ASP A1068
LEU A1041
ILE A1006
HIS A 998
ATP  A1200 (-3.6A)
None
SEP  A1042 ( 3.7A)
None
None
1.44A 5dv4A-5lpyA:
undetectable
5dv4A-5lpyA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB5_B_010B607_0
(HNL ISOENZYME 5)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 10 ALA A 987
ALA A 991
VAL A1151
LEU A1080
VAL A1133
None
1.48A 5eb5B-5lpyA:
undetectable
5eb5B-5lpyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
3 / 3 THR A1049
ASP A1027
GLU A 923
None
ATP  A1200 (-4.1A)
None
0.85A 5fa8A-5lpyA:
undetectable
5fa8A-5lpyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 ILE A 889
ALA A 909
LYS A 911
GLU A 927
GLY A 962
LEU A1016
SER A1026
None
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
ATP  A1200 ( 4.7A)
0.74A 5i9yA-5lpyA:
23.8
5i9yA-5lpyA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
4 / 7 GLY A 890
VAL A 897
LYS A 911
LEU A 913
ATP  A1200 ( 4.6A)
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.8A)
None
0.38A 5izjA-5lpyA:
21.1
5izjA-5lpyA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 12 ALA A 909
LEU A 939
VAL A 940
HIS A1007
LEU A1016
ATP  A1200 (-3.5A)
None
None
None
ATP  A1200 (-4.6A)
0.60A 5mo4A-5lpyA:
16.9
5mo4A-5lpyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 12 SER A 990
LEU A1076
LEU A1077
GLU A1078
LEU A1079
None
0.92A 5nwwA-5lpyA:
undetectable
5nwwA-5lpyA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 ALA A 909
GLU A 927
VAL A 940
PHE A 958
GLY A 962
LEU A1016
ATP  A1200 (-3.5A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.66A 5te0A-5lpyA:
24.3
5te0A-5lpyA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC3_A_DB8A601_1
(WEE1-LIKE PROTEIN
KINASE)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 ILE A 889
GLY A 890
ALA A 909
GLU A 927
GLY A 962
ASP A 966
ASP A1027
None
ATP  A1200 ( 4.6A)
ATP  A1200 (-3.5A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.9A)
ATP  A1200 (-4.1A)
0.84A 5vc3A-5lpyA:
25.1
5vc3A-5lpyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 GLY A 890
VAL A 897
ALA A 909
LYS A 911
LEU A 954
LEU A1016
ASP A1027
ATP  A1200 ( 4.6A)
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.89A 5yu9A-5lpyA:
22.1
5yu9A-5lpyA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 GLY A 890
VAL A 897
ALA A 909
LYS A 911
LEU A 954
LEU A1016
ASP A1027
ATP  A1200 ( 4.6A)
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
0.90A 5yu9B-5lpyA:
22.0
5yu9B-5lpyA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 GLY A 890
VAL A 897
LYS A 911
LEU A 954
ASP A 966
LEU A1016
ASP A1027
ATP  A1200 ( 4.6A)
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 (-3.9A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
1.04A 5yu9B-5lpyA:
22.0
5yu9B-5lpyA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 ILE A 910
ALA A 900
ALA A 879
PHE A 883
CYH A 946
LEU A 871
None
1.48A 6a5yD-5lpyA:
undetectable
6a5yD-5lpyA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 LEU A1127
LEU A1123
ALA A 987
SER A 990
LEU A1080
LEU A 968
None
1.00A 6ew0B-5lpyA:
undetectable
6ew0B-5lpyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 LEU A1127
LEU A1123
ALA A 987
SER A 990
LEU A1080
LEU A 968
None
1.01A 6ew0D-5lpyA:
undetectable
6ew0D-5lpyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 12 LEU A1127
ALA A 987
SER A 990
LEU A1080
LEU A 968
None
0.97A 6ew0F-5lpyA:
undetectable
6ew0F-5lpyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
5 / 12 LEU A1127
ALA A 987
SER A 990
LEU A1080
LEU A 968
None
0.97A 6ew0G-5lpyA:
undetectable
6ew0G-5lpyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 LEU A1127
LEU A1123
ALA A 987
SER A 990
LEU A1080
LEU A 968
None
1.01A 6ew0H-5lpyA:
undetectable
6ew0H-5lpyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
6 / 12 LEU A1127
LEU A1123
ALA A 987
SER A 990
LEU A1080
LEU A 968
None
1.00A 6ew0I-5lpyA:
undetectable
6ew0I-5lpyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 ILE A 889
VAL A 897
ALA A 909
LYS A 911
GLU A 927
MET A 959
LEU A1016
None
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
ATP  A1200 (-4.6A)
0.66A 6fnmA-5lpyA:
24.0
6fnmA-5lpyA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNM_A_1N1A1001_1
(-)
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana)
7 / 12 ILE A 889
VAL A 897
ALA A 909
LYS A 911
MET A 959
GLY A 962
LEU A1016
None
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.61A 6fnmA-5lpyA:
24.0
6fnmA-5lpyA:
28.25