SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lq4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		4 / 8 MET A 197
LEU A 184
VAL A 150
GLY A 151
 None
 0.98A 1hrkA-5lq4A:
undetectable		 1hrkA-5lq4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		4 / 8 MET A 197
LEU A 184
VAL A 150
GLY A 151
 None
 1.00A 1hrkB-5lq4A:
undetectable		 1hrkB-5lq4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		5 / 12 PHE A 164
PHE A 188
GLY A 151
ALA A 152
LEU A 173
 None
 0.98A 1igxA-5lq4A:
undetectable		 1igxA-5lq4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		5 / 12 LEU A 184
LEU A 187
LEU A 190
MET A 197
LEU A 119
 None
 1.02A 1sqnB-5lq4A:
undetectable		 1sqnB-5lq4A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		4 / 4 LEU A 191
PRO A  92
ILE A 145
LEU A 143
 None
 0.99A 1ya4B-5lq4A:
undetectable		 1ya4B-5lq4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		4 / 4 LEU A 191
PRO A  92
ILE A 145
LEU A 143
 None
 1.07A 1ya4C-5lq4A:
undetectable		 1ya4C-5lq4A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		5 / 12 LEU A 184
LEU A 187
LEU A 190
MET A 197
LEU A 134
 None
 1.05A 1zucB-5lq4A:
undetectable		 1zucB-5lq4A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		5 / 11 LEU A 400
VAL A 459
ALA A 395
LEU A 334
SER A 327
 None
 1.10A 2bxgA-5lq4A:
undetectable		 2bxgA-5lq4A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		5 / 9 LEU A 143
LEU A 134
ILE A 154
LEU A 187
ILE A  94
 None
 1.21A 2f78A-5lq4A:
undetectable		 2f78A-5lq4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		5 / 9 LEU A 143
LEU A 134
ILE A 154
LEU A 187
ILE A  94
 None
 1.21A 2f78B-5lq4A:
undetectable		 2f78B-5lq4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		5 / 9 LEU A 143
LEU A 134
ILE A 154
LEU A 187
ILE A  94
 None
 1.24A 2f7aA-5lq4A:
undetectable		 2f7aA-5lq4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		4 / 8 LEU A  13
SER A  26
ASP A  29
ASP A  28
 None
 1.05A 2j2pA-5lq4A:
undetectable
2j2pB-5lq4A:
undetectable		 2j2pA-5lq4A:
17.70
2j2pB-5lq4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		4 / 6 LEU A  13
SER A  26
ASP A  29
ASP A  28
 None
 1.03A 2j2pE-5lq4A:
undetectable
2j2pF-5lq4A:
undetectable		 2j2pE-5lq4A:
17.70
2j2pF-5lq4A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		3 / 3 ARG A 323
GLN A 354
PRO A 355
 None
 0.99A 2qhfA-5lq4A:
undetectable		 2qhfA-5lq4A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		4 / 8 PHE A 397
ILE A 412
PHE A 445
GLY A 460
 None
 0.89A 2qx4A-5lq4A:
undetectable
2qx4B-5lq4A:
undetectable		 2qx4A-5lq4A:
17.14
2qx4B-5lq4A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		4 / 8 LEU A 157
LEU A 184
LYS A 185
LEU A 191
 None
 0.86A 2xn3A-5lq4A:
undetectable
2xn3B-5lq4A:
undetectable		 2xn3A-5lq4A:
20.34
2xn3B-5lq4A:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		3 / 3 ARG A 300
PRO A 434
PHE A 297
 None
 0.77A 3thrC-5lq4A:
undetectable		 3thrC-5lq4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		3 / 3 HIS A 361
HIS A 352
ILE A 249
 None
 0.85A 3u52A-5lq4A:
undetectable
3u52C-5lq4A:
undetectable		 3u52A-5lq4A:
22.46
3u52C-5lq4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		5 / 12 PHE A 164
PHE A 188
GLY A 151
ALA A 152
LEU A 173
 None
 1.05A 4e1gA-5lq4A:
undetectable		 4e1gA-5lq4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		5 / 12 PHE A 164
PHE A 188
GLY A 151
ALA A 152
LEU A 173
 None
 1.05A 4e1gB-5lq4A:
undetectable		 4e1gB-5lq4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		4 / 7 ALA A 193
TYR A 103
LEU A 105
TRP A 112
 None
 0.95A 4iomA-5lq4A:
undetectable		 4iomA-5lq4A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		4 / 7 THR A 381
ALA A 377
LEU A 373
SER A 372
 FMN  A 901 (-4.6A)
None
None
None
 1.01A 4pwjB-5lq4A:
undetectable		 4pwjB-5lq4A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		4 / 7 THR A 381
ALA A 377
LEU A 373
SER A 372
 FMN  A 901 (-4.6A)
None
None
None
 1.05A 5bojB-5lq4A:
undetectable		 5bojB-5lq4A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		3 / 3 ASP A   3
GLU A  78
SER A 110
 None
 0.84A 5bw4B-5lq4A:
undetectable		 5bw4B-5lq4A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		5 / 10 LEU A  40
PRO A  38
GLY A  70
GLU A  68
GLY A  66
 None
 1.10A 5o96E-5lq4A:
undetectable
5o96F-5lq4A:
undetectable		 5o96E-5lq4A:
20.34
5o96F-5lq4A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		3 / 3 VAL A 144
VAL A 133
GLN A 127
 None
 0.65A 5qgnA-5lq4A:
undetectable		 5qgnA-5lq4A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 5lq4 CYAGOX
(Cyanothece
sp.
PCC
7425) 		4 / 7 ARG A 278
THR A 381
ILE A 437
ALA A 436
 FMN  A 901 (-2.9A)
FMN  A 901 (-4.6A)
FMN  A 901 (-4.7A)
FMN  A 901 (-3.5A)
 0.92A 6ma7A-5lq4A:
undetectable		 6ma7A-5lq4A:
9.43