SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lq8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		5 / 12 TYR A 260
GLY A  64
LEU A  60
ALA A  82
TRP A 208
 None
GB  A 401 (-3.3A)
None
None
None
 1.48A 1e3vA-5lq8A:
undetectable		 1e3vA-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		5 / 12 TYR A 260
GLY A  68
LEU A  60
ALA A  82
TRP A 208
 None
 1.24A 1e3vA-5lq8A:
undetectable		 1e3vA-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		5 / 11 TYR A 260
GLY A  68
LEU A  60
ALA A  82
TRP A 208
 None
 1.23A 1e3vB-5lq8A:
undetectable		 1e3vB-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		5 / 12 GLN A  74
THR A  75
SER A  78
GLY A 267
LEU A  66
 None
 1.14A 1jg4A-5lq8A:
undetectable		 1jg4A-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		4 / 8 TYR A 206
ASP A 205
SER A 128
TYR A 203
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
GB  A 401 (-2.7A)
None
 1.26A 2bteA-5lq8A:
undetectable		 2bteA-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		4 / 8 TYR A 206
ASP A 205
TYR A 203
HIS A 158
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
None
GB  A 401 (-4.0A)
 1.25A 2bteA-5lq8A:
undetectable		 2bteA-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		4 / 8 TYR A 206
ASP A 205
SER A 128
TYR A 203
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
GB  A 401 (-2.7A)
None
 1.26A 2bteD-5lq8A:
undetectable		 2bteD-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		4 / 8 TYR A 206
ASP A 205
TYR A 203
HIS A 158
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
None
GB  A 401 (-4.0A)
 1.31A 2bteD-5lq8A:
undetectable		 2bteD-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		4 / 7 TYR A 206
ASP A 205
TYR A 203
HIS A 158
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
None
GB  A 401 (-4.0A)
 1.21A 2bytA-5lq8A:
undetectable		 2bytA-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		4 / 7 TYR A 206
ASP A 205
TYR A 203
HIS A 158
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
None
GB  A 401 (-4.0A)
 1.21A 2bytD-5lq8A:
undetectable		 2bytD-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		4 / 5 PRO A  12
PRO A  42
ILE A  41
GLY A   9
 None
 1.07A 2jkjD-5lq8A:
undetectable		 2jkjD-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		4 / 5 PRO A  12
PRO A  42
ILE A  41
GLY A   9
 None
 1.07A 2jkjF-5lq8A:
undetectable		 2jkjF-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		3 / 3 ARG A  84
ASN A 262
THR A 127
 None
None
GB  A 401 (-3.7A)
 0.79A 2q63A-5lq8A:
undetectable		 2q63A-5lq8A:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		4 / 5 TYR A 206
ASP A 205
TYR A 203
HIS A 158
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
None
GB  A 401 (-4.0A)
 1.21A 2v0gD-5lq8A:
undetectable		 2v0gD-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		4 / 6 VAL A 179
SER A 126
ALA A  10
PHE A  23
 None
GB  A 401 (-2.6A)
None
None
 1.21A 4nedA-5lq8A:
10.4		 4nedA-5lq8A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		4 / 8 ARG A  84
ASP A  13
ASP A 205
ASP A  87
 None
None
GB  A 401 (-2.7A)
None
 1.14A 4xqgB-5lq8A:
undetectable		 4xqgB-5lq8A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		5 / 12 ILE A 243
LEU A  19
VAL A   8
LEU A 233
PHE A 247
 None
 1.21A 5bykA-5lq8A:
undetectable		 5bykA-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		5 / 12 LEU A 117
LEU A 175
LEU A 114
ILE A 199
LEU A 196
 None
 1.15A 5ienB-5lq8A:
undetectable		 5ienB-5lq8A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER
(Prochlorococcus
marinus) 		4 / 6 PHE A 119
LEU A 114
ALA A 172
THR A 200
 None
 0.94A 6f88A-5lq8A:
undetectable		 6f88A-5lq8A:
16.25