SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lqd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 5 GLU A 390
ALA A 386
SER A 383
HIS A 400
 None
 1.13A 1errA-5lqdA:
undetectable
1errB-5lqdA:
undetectable		 1errA-5lqdA:
19.87
1errB-5lqdA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		3 / 3 GLU A 390
ALA A 386
SER A 383
 None
 0.56A 1errB-5lqdA:
undetectable		 1errB-5lqdA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 8 SER A 383
ILE A 270
VAL A 366
SER A 344
 None
 1.17A 1kb9A-5lqdA:
undetectable
1kb9C-5lqdA:
undetectable
1kb9D-5lqdA:
undetectable
1kb9E-5lqdA:
undetectable		 1kb9A-5lqdA:
25.24
1kb9C-5lqdA:
20.93
1kb9D-5lqdA:
19.55
1kb9E-5lqdA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		5 / 12 ARG A 113
ILE A  85
LEU A  93
PHE A 110
LEU A 304
 None
None
None
EDO  A1001 ( 4.7A)
None
 1.16A 1og5B-5lqdA:
undetectable		 1og5B-5lqdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 8 ALA A 206
PHE A 207
ALA A 211
LEU A 191
 None
 0.89A 2bxmA-5lqdA:
undetectable		 2bxmA-5lqdA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 5 LEU A 397
LEU A 411
CYH A 378
THR A 426
 None
 1.26A 2oaxD-5lqdA:
undetectable		 2oaxD-5lqdA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		5 / 12 THR A 165
ALA A 146
PHE A 198
ALA A 193
THR A 218
 None
 1.08A 2ve3A-5lqdA:
undetectable		 2ve3A-5lqdA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 6 VAL A 373
VAL A 372
ARG A 233
ARG A 428
 None
 1.21A 3bjwF-5lqdA:
undetectable		 3bjwF-5lqdA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 5 GLN A 151
THR A 165
HIS A  94
LEU A  90
 None
 1.14A 3ce6C-5lqdA:
3.6		 3ce6C-5lqdA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 7 LEU A 382
THR A 200
THR A 407
ARG A 360
 None
 1.27A 3nxuA-5lqdA:
undetectable		 3nxuA-5lqdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 6 SER A  44
ASP A  43
SER A   3
ASP A 133
 None
 1.26A 4eysA-5lqdA:
undetectable		 4eysA-5lqdA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 7 ALA A 170
PRO A 172
TYR A  98
LEU A  93
 None
 1.01A 4iomA-5lqdA:
2.5		 4iomA-5lqdA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		5 / 12 ALA A 211
PHE A 175
LEU A 178
GLY A 192
LEU A 147
 None
 1.26A 4kykA-5lqdA:
undetectable
4kykB-5lqdA:
undetectable		 4kykA-5lqdA:
15.48
4kykB-5lqdA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 5 GLN A 151
THR A 165
HIS A  94
LEU A  90
 None
 1.36A 4lvcA-5lqdA:
4.1		 4lvcA-5lqdA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 5 GLN A 151
THR A 165
HIS A  94
LEU A  90
 None
 1.37A 4lvcC-5lqdA:
4.4		 4lvcC-5lqdA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		5 / 11 ARG A 244
VAL A 252
GLY A 253
THR A 257
LEU A 294
 None
 1.31A 4or0A-5lqdA:
undetectable		 4or0A-5lqdA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 7 ASP A 262
TYR A 310
SER A 383
ASN A 357
 None
 1.15A 5l1fC-5lqdA:
4.3		 5l1fC-5lqdA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 5 SER A 296
ALA A 297
GLN A 302
THR A 311
 None
 1.28A 5n4iA-5lqdA:
undetectable		 5n4iA-5lqdA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		5 / 10 ALA A 379
LEU A 380
VAL A 381
LEU A 429
GLU A 421
 None
 1.13A 5v02B-5lqdA:
undetectable
5v02R-5lqdA:
undetectable		 5v02B-5lqdA:
10.97
5v02R-5lqdA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 5 GLN A 151
THR A 165
HIS A  94
LEU A  90
 None
 1.37A 6gbnA-5lqdA:
3.4		 6gbnA-5lqdA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(Streptomyces
venezuelae) 		4 / 5 GLN A 151
THR A 165
HIS A  94
LEU A  90
 None
 1.38A 6gbnD-5lqdA:
3.4		 6gbnD-5lqdA:
20.99