SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lrb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 11 LEU A 159
ALA A 101
SER A 105
THR A 102
VAL A 169
 None
 1.26A 1ictA-5lrbA:
undetectable
1ictC-5lrbA:
undetectable		 1ictA-5lrbA:
9.23
1ictC-5lrbA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		3 / 3 ASP A 694
PHE A 815
VAL A 697
 None
 0.72A 1kijB-5lrbA:
undetectable		 1kijB-5lrbA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 5 ILE A 952
ILE A 966
ILE A 962
LEU A 643
 None
 0.85A 1zgyA-5lrbA:
undetectable		 1zgyA-5lrbA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 TYR A 155
TRP A 236
SER A 109
GLY A 147
ILE A 146
 None
 1.25A 2dcfA-5lrbA:
undetectable		 2dcfA-5lrbA:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		8 / 10 ASN A 180
LEU A 183
TYR A 329
ASP A 332
ARG A 341
ASP A 383
HIS A 385
HIS A 701
 None
GLC  A1001 (-4.3A)
None
None
None
None
None
None
 0.52A 2ecpA-5lrbA:
51.4		 2ecpA-5lrbA:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		8 / 10 ASN A 180
TYR A 329
ASP A 332
ARG A 341
ASP A 383
HIS A 385
ARG A 699
HIS A 701
 None
None
None
None
None
None
GLC  A1001 ( 4.9A)
None
 0.78A 2ecpA-5lrbA:
51.4		 2ecpA-5lrbA:
39.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_B_ACRB992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		9 / 10 ASN A 180
LEU A 183
TYR A 329
ASP A 332
ARG A 341
ASP A 383
HIS A 385
ARG A 699
HIS A 701
 None
GLC  A1001 (-4.3A)
None
None
None
None
None
GLC  A1001 ( 4.9A)
None
 0.73A 2ecpB-5lrbA:
52.0		 2ecpB-5lrbA:
39.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 11 VAL A 416
ILE A 390
ILE A 396
VAL A 377
VAL A 379
 None
 1.00A 2nnpB-5lrbA:
undetectable		 2nnpB-5lrbA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		3 / 3 ARG A 359
SER A 358
TYR A 118
 None
 1.02A 2q2hA-5lrbA:
undetectable
2q2hB-5lrbA:
undetectable		 2q2hA-5lrbA:
9.47
2q2hB-5lrbA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 ILE A 390
THR A 387
LEU A 573
HIS A 443
LEU A 440
 None
 0.96A 2qo5A-5lrbA:
undetectable		 2qo5A-5lrbA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 LEU A 110
VAL A 106
SER A 948
SER A 947
ASN A 144
 None
 1.46A 2y00A-5lrbA:
undetectable		 2y00A-5lrbA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA512_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 10 TYR A 155
TRP A 236
SER A 109
GLY A 147
ILE A 146
 None
 1.27A 2zm8A-5lrbA:
undetectable		 2zm8A-5lrbA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 11 TYR A 155
TRP A 236
SER A 109
GLY A 147
ILE A 146
 None
 1.26A 2zmaA-5lrbA:
undetectable		 2zmaA-5lrbA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 6 VAL A 584
ASP A 383
TYR A 131
ASN A 613
 None
None
None
GLC  A1001 (-3.8A)
 1.48A 2zs9A-5lrbA:
undetectable		 2zs9A-5lrbA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 TYR A 155
TRP A 236
SER A 109
GLY A 147
ILE A 146
 None
 1.34A 3a65A-5lrbA:
undetectable		 3a65A-5lrbA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		3 / 3 TRP A 263
VAL A 568
ARG A 478
 None
 0.96A 3b0wA-5lrbA:
undetectable		 3b0wA-5lrbA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 7 VAL A 272
LYS A 270
ILE A 269
LEU A 440
 None
 0.91A 3bjwH-5lrbA:
undetectable		 3bjwH-5lrbA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 LEU A 368
GLU A 361
LEU A 397
LEU A 403
GLY A 402
 None
 1.28A 3g1uA-5lrbA:
undetectable		 3g1uA-5lrbA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 LEU A 368
GLU A 361
LEU A 397
LEU A 403
GLY A 402
 None
 1.24A 3g1uC-5lrbA:
3.3		 3g1uC-5lrbA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 6 PRO A 297
SER A 350
THR A 294
THR A 295
 None
 1.14A 3tneA-5lrbA:
undetectable		 3tneA-5lrbA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 TYR A 715
ILE A 710
GLU A 872
GLU A 722
VAL A 776
 None
 1.33A 4a97A-5lrbA:
1.2
4a97B-5lrbA:
1.3		 4a97A-5lrbA:
15.70
4a97B-5lrbA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 5 THR A 415
ILE A 411
GLU A 371
PHE A 360
 None
 1.48A 4acaC-5lrbA:
7.3		 4acaC-5lrbA:
20.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 8 MET A 398
TRP A 405
ARG A 442
GLU A 445
 None
 0.25A 4bqfB-5lrbA:
59.9		 4bqfB-5lrbA:
55.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 7 ASN A 572
ALA A 571
VAL A 581
TYR A 418
 None
 1.14A 4ijiH-5lrbA:
undetectable		 4ijiH-5lrbA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 LEU A 480
ARG A 569
ALA A 490
ILE A 450
GLY A 577
 None
 1.27A 4l9qA-5lrbA:
undetectable		 4l9qA-5lrbA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 7 GLU A 602
LEU A 454
PHE A 600
TYR A 462
 None
 1.12A 4twdF-5lrbA:
undetectable
4twdJ-5lrbA:
undetectable		 4twdF-5lrbA:
15.73
4twdJ-5lrbA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		3 / 3 LYS A 104
ARG A 240
VAL A 239
 None
 0.85A 4x3uA-5lrbA:
0.4
4x3uB-5lrbA:
undetectable		 4x3uA-5lrbA:
5.76
4x3uB-5lrbA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		3 / 3 LYS A 698
ARG A 699
HIS A 701
 PLP  A1002 (-2.8A)
GLC  A1001 ( 4.9A)
None
 1.07A 4zbrA-5lrbA:
undetectable		 4zbrA-5lrbA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 5 VAL A 575
TYR A 346
ILE A 269
PRO A 386
 None
 1.23A 4ze1A-5lrbA:
undetectable		 4ze1A-5lrbA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 7 VAL A 444
GLN A 437
LEU A 433
SER A 432
 None
 0.81A 4zphA-5lrbA:
undetectable
4zphB-5lrbA:
undetectable		 4zphA-5lrbA:
18.50
4zphB-5lrbA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 ALA A 187
GLY A 179
GLY A 184
GLY A 182
LEU A 178
 None
None
None
GLC  A1001 ( 3.7A)
None
 0.91A 5c0oH-5lrbA:
2.2		 5c0oH-5lrbA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		3 / 3 ARG A 240
ASN A 115
ASP A 108
 None
 0.85A 5gwxA-5lrbA:
undetectable		 5gwxA-5lrbA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 8 ASN A 288
TRP A 229
PHE A 136
HIS A 274
 None
 1.29A 5hqaA-5lrbA:
undetectable		 5hqaA-5lrbA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 8 TYR A 131
PHE A 190
ILE A 959
TRP A 960
 None
 0.95A 5hw8H-5lrbA:
undetectable		 5hw8H-5lrbA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 GLN A 344
HIS A 385
LEU A 132
LEU A 328
TYR A 329
 None
 1.48A 5ji0D-5lrbA:
undetectable		 5ji0D-5lrbA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_2
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		3 / 3 VAL A 873
LYS A 721
MET A 723
 None
 0.86A 5nknA-5lrbA:
undetectable		 5nknA-5lrbA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		7 / 10 GLY A 182
HIS A 421
VAL A 584
ASN A 613
LYS A 704
GLU A 806
GLY A 809
 GLC  A1001 ( 3.7A)
GLC  A1001 (-3.7A)
None
GLC  A1001 (-3.8A)
GLC  A1001 (-3.1A)
GLC  A1001 (-3.4A)
GLC  A1001 ( 3.6A)
 0.81A 5vncC-5lrbA:
16.4		 5vncC-5lrbA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 11 VAL A 106
ALA A 145
SER A 109
LEU A 110
ASN A 113
 None
 1.17A 5x6yA-5lrbA:
undetectable		 5x6yA-5lrbA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 11 ASP A 275
PRO A 200
ALA A 129
ALA A 126
TYR A 121
 None
 1.40A 6bm5A-5lrbA:
undetectable		 6bm5A-5lrbA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 7 ARG A 359
TYR A 204
LEU A 191
TYR A 130
 None
 1.34A 6g2pA-5lrbA:
0.9		 6g2pA-5lrbA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		6 / 12 GLY A 181
GLY A 182
ASP A 383
VAL A 584
ASN A 613
GLY A 809
 PLP  A1002 ( 4.3A)
GLC  A1001 ( 3.7A)
None
None
GLC  A1001 (-3.8A)
GLC  A1001 ( 3.6A)
 0.71A 6gneA-5lrbA:
22.2		 6gneA-5lrbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		6 / 12 GLY A 182
ASP A 383
VAL A 584
ASN A 613
ARG A 699
GLY A 809
 GLC  A1001 ( 3.7A)
None
None
GLC  A1001 (-3.8A)
GLC  A1001 ( 4.9A)
GLC  A1001 ( 3.6A)
 0.94A 6gneA-5lrbA:
22.2		 6gneA-5lrbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		7 / 12 GLU A 135
GLY A 181
GLY A 182
ASP A 383
VAL A 584
ASN A 613
GLY A 809
 None
PLP  A1002 ( 4.3A)
GLC  A1001 ( 3.7A)
None
None
GLC  A1001 (-3.8A)
GLC  A1001 ( 3.6A)
 0.69A 6gneB-5lrbA:
22.0		 6gneB-5lrbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		7 / 12 GLU A 135
GLY A 182
ASP A 383
VAL A 584
ASN A 613
ARG A 699
GLY A 809
 None
GLC  A1001 ( 3.7A)
None
None
GLC  A1001 (-3.8A)
GLC  A1001 ( 4.9A)
GLC  A1001 ( 3.6A)
 0.89A 6gneB-5lrbA:
22.0		 6gneB-5lrbA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		7 / 12 ASP A 332
ASP A 383
HIS A 385
ASN A 613
ARG A 699
GLU A 806
GLY A 809
 None
None
None
GLC  A1001 (-3.8A)
GLC  A1001 ( 4.9A)
GLC  A1001 (-3.4A)
GLC  A1001 ( 3.6A)
 0.95A 6gnfA-5lrbA:
22.9		 6gnfA-5lrbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 9 GLY A 181
GLY A 182
TYR A 329
HIS A 421
VAL A 584
 PLP  A1002 ( 4.3A)
GLC  A1001 ( 3.7A)
None
GLC  A1001 (-3.7A)
None
 0.68A 6gnfA-5lrbA:
22.9		 6gnfA-5lrbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 10 GLY A 182
LEU A 183
TYR A 329
HIS A 421
VAL A 584
 GLC  A1001 ( 3.7A)
GLC  A1001 (-4.3A)
None
GLC  A1001 (-3.7A)
None
 0.78A 6gnfC-5lrbA:
23.1		 6gnfC-5lrbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		7 / 12 ASP A 332
ASP A 383
HIS A 385
ASN A 613
ARG A 699
GLU A 806
GLY A 809
 None
None
None
GLC  A1001 (-3.8A)
GLC  A1001 ( 4.9A)
GLC  A1001 (-3.4A)
GLC  A1001 ( 3.6A)
 0.95A 6gnfC-5lrbA:
23.1		 6gnfC-5lrbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 GLY A 181
LEU A 183
ASP A 383
HIS A 385
ASN A 613
 PLP  A1002 ( 4.3A)
GLC  A1001 (-4.3A)
None
None
GLC  A1001 (-3.8A)
 0.79A 6gngA-5lrbA:
22.4		 6gngA-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 GLY A 181
LEU A 183
GLY A 331
ASP A 383
HIS A 385
 PLP  A1002 ( 4.3A)
GLC  A1001 (-4.3A)
None
None
None
 1.10A 6gngA-5lrbA:
22.4		 6gngA-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		8 / 12 GLU A 135
GLY A 182
TYR A 329
HIS A 421
VAL A 584
ARG A 699
GLU A 806
GLY A 809
 None
GLC  A1001 ( 3.7A)
None
GLC  A1001 (-3.7A)
None
GLC  A1001 ( 4.9A)
GLC  A1001 (-3.4A)
GLC  A1001 ( 3.6A)
 0.90A 6gngA-5lrbA:
22.4		 6gngA-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 TYR A 329
HIS A 421
VAL A 584
GLU A 806
GLY A 809
 None
GLC  A1001 (-3.7A)
None
GLC  A1001 (-3.4A)
GLC  A1001 ( 3.6A)
 0.83A 6gngB-5lrbA:
22.4		 6gngB-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		6 / 12 GLU A 135
GLY A 181
GLY A 182
LEU A 183
GLY A 331
HIS A 385
 None
PLP  A1002 ( 4.3A)
GLC  A1001 ( 3.7A)
GLC  A1001 (-4.3A)
None
None
 1.18A 6gngB-5lrbA:
22.4		 6gngB-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 GLU A 135
GLY A 181
LEU A 183
GLY A 331
HIS A 385
 None
PLP  A1002 ( 4.3A)
GLC  A1001 (-4.3A)
None
None
 1.10A 6gngB-5lrbA:
22.4		 6gngB-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		5 / 12 GLU A 135
GLY A 182
LEU A 183
HIS A 385
ARG A 699
 None
GLC  A1001 ( 3.7A)
GLC  A1001 (-4.3A)
None
GLC  A1001 ( 4.9A)
 0.75A 6gngB-5lrbA:
22.4		 6gngB-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE
(Hordeum
vulgare) 		4 / 7 ARG A 442
ALA A 408
THR A 412
ILE A 390
 None
 0.99A 6ma7A-5lrbA:
undetectable		 6ma7A-5lrbA:
6.49