SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ls0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1
(Arabidopsis
thaliana) 		5 / 9 ALA A 194
ASP A 136
GLY A 124
VAL A  91
ILE A 102
 None
 1.07A 1hpvB-5ls0A:
undetectable		 1hpvB-5ls0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1
(Arabidopsis
thaliana) 		5 / 11 ALA A 120
VAL A  91
ILE A 195
ILE A 139
VAL A  51
 None
 0.77A 2nnpB-5ls0A:
undetectable		 2nnpB-5ls0A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1
(Arabidopsis
thaliana) 		4 / 4 TYR A 202
LEU A 201
LEU A  95
HIS A  37
 None
 1.44A 2x7hB-5ls0A:
undetectable		 2x7hB-5ls0A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1
(Arabidopsis
thaliana) 		4 / 8 PHE A  49
VAL A  52
LEU A  39
PRO A  92
 None
 1.02A 3bgdB-5ls0A:
undetectable		 3bgdB-5ls0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1
(Arabidopsis
thaliana) 		5 / 11 ALA A 194
ASP A 136
GLY A 124
VAL A  91
ILE A 102
 None
 1.01A 3ekxB-5ls0A:
undetectable		 3ekxB-5ls0A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1
(Arabidopsis
thaliana) 		3 / 3 LYS A 173
ARG A  76
ASP A  98
 None
 1.26A 3o7wA-5ls0A:
undetectable		 3o7wA-5ls0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1
(Arabidopsis
thaliana) 		5 / 8 ILE A  41
ILE A 195
ALA A 122
VAL A  91
PRO A  92
 None
 1.32A 4jltA-5ls0A:
undetectable		 4jltA-5ls0A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1
(Arabidopsis
thaliana) 		3 / 3 TYR A 172
ARG A  76
LYS A 173
 None
 1.30A 4wq5B-5ls0A:
undetectable		 4wq5B-5ls0A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1
(Arabidopsis
thaliana) 		5 / 12 ASP A  66
PRO A 101
GLY A  89
GLU A  54
GLU A  64
 None
None
None
MG  A 301 ( 4.2A)
None
 1.20A 5hfjD-5ls0A:
undetectable		 5hfjD-5ls0A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_J_EDTJ301_0
(TCRBETA CHAIN)		 5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1
(Arabidopsis
thaliana) 		4 / 5 TYR A  84
LYS A  62
GLU A  54
GLY A  89
 None
None
MG  A 301 ( 4.2A)
None
 1.06A 5jhdJ-5ls0A:
undetectable		 5jhdJ-5ls0A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1
(Arabidopsis
thaliana) 		5 / 12 ALA A 120
VAL A  91
ILE A 195
ILE A 139
VAL A  51
 None
 0.80A 6dh0A-5ls0A:
undetectable		 6dh0A-5ls0A:
18.71