SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ls4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 11 GLY A 393
HIS A 432
ALA A 531
ILE A 391
ARG A 493
 None
 1.36A 1gtfU-5ls4A:
undetectable
1gtfV-5ls4A:
undetectable		 1gtfU-5ls4A:
15.84
1gtfV-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_M_TRPM81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 11 GLY A 393
HIS A 432
ALA A 531
ILE A 391
ARG A 493
 None
 1.34A 1utdM-5ls4A:
undetectable
1utdN-5ls4A:
undetectable		 1utdM-5ls4A:
15.84
1utdN-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		4 / 6 HIS A 529
HIS A 510
GLU A 400
ASP A 534
 None
ZN  A 602 (-3.2A)
ZN  A 602 (-2.4A)
CA  A 601 (-3.3A)
 1.28A 4apjA-5ls4A:
undetectable
4apjP-5ls4A:
undetectable		 4apjA-5ls4A:
15.40
4apjP-5ls4A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.32A 5eeuD-5ls4A:
undetectable
5eeuE-5ls4A:
undetectable		 5eeuD-5ls4A:
15.84
5eeuE-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.35A 5eeuJ-5ls4A:
undetectable
5eeuK-5ls4A:
undetectable		 5eeuJ-5ls4A:
15.84
5eeuK-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.32A 5eevD-5ls4A:
undetectable
5eevE-5ls4A:
undetectable		 5eevD-5ls4A:
15.84
5eevE-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.35A 5eevJ-5ls4A:
undetectable
5eevK-5ls4A:
undetectable		 5eevJ-5ls4A:
15.84
5eevK-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.33A 5eewD-5ls4A:
undetectable
5eewE-5ls4A:
undetectable		 5eewD-5ls4A:
15.84
5eewE-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.35A 5eewJ-5ls4A:
undetectable
5eewK-5ls4A:
undetectable		 5eewJ-5ls4A:
15.84
5eewK-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.33A 5eexD-5ls4A:
undetectable
5eexE-5ls4A:
undetectable		 5eexD-5ls4A:
15.84
5eexE-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.35A 5eexJ-5ls4A:
undetectable
5eexK-5ls4A:
undetectable		 5eexJ-5ls4A:
15.84
5eexK-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.32A 5eeyD-5ls4A:
undetectable
5eeyE-5ls4A:
undetectable		 5eeyD-5ls4A:
15.84
5eeyE-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_J_TRPJ101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.35A 5eeyJ-5ls4A:
undetectable
5eeyK-5ls4A:
undetectable		 5eeyJ-5ls4A:
15.84
5eeyK-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.32A 5eezD-5ls4A:
undetectable
5eezE-5ls4A:
undetectable		 5eezD-5ls4A:
15.84
5eezE-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.32A 5ef0D-5ls4A:
undetectable
5ef0E-5ls4A:
undetectable		 5ef0D-5ls4A:
15.84
5ef0E-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.32A 5ef1D-5ls4A:
undetectable
5ef1E-5ls4A:
undetectable		 5ef1D-5ls4A:
15.84
5ef1E-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.32A 5ef2D-5ls4A:
undetectable
5ef2E-5ls4A:
undetectable		 5ef2D-5ls4A:
15.84
5ef2E-5ls4A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5ls4 NUCLEOPROTEIN
(Mopeia
mammarenavirus) 		5 / 10 ARG A 493
GLY A 393
HIS A 432
ALA A 531
ILE A 391
 None
 1.33A 5ef3D-5ls4A:
undetectable
5ef3E-5ls4A:
undetectable		 5ef3D-5ls4A:
15.84
5ef3E-5ls4A:
15.84