SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lsk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_A_H4BA700_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.15A 1d1vA-5lskN:
undetectable
1d1vB-5lskN:
undetectable		 1d1vA-5lskN:
19.05
1d1vB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1V_B_H4BB701_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 1d1vA-5lskN:
undetectable
1d1vB-5lskN:
undetectable		 1d1vA-5lskN:
19.05
1d1vB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1W_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.15A 1d1wA-5lskN:
undetectable
1d1wB-5lskN:
undetectable		 1d1wA-5lskN:
19.05
1d1wB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1X_B_H4BB601_1
(BOVINE ENDOTHELIAL
NITRIC OXIDE
SYNTHASE HEME DOMAIN)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.10A 1d1xA-5lskN:
undetectable
1d1xB-5lskN:
undetectable		 1d1xA-5lskN:
19.05
1d1xB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DM8_A_H4BA1600_1
(NITRIC OXIDE
SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.14A 1dm8A-5lskN:
undetectable
1dm8B-5lskN:
undetectable		 1dm8A-5lskN:
19.05
1dm8B-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMI_B_BHSB2610_1
(NITRIC OXIDE
SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.09A 1dmiA-5lskN:
undetectable
1dmiB-5lskN:
undetectable		 1dmiA-5lskN:
19.05
1dmiB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.13A 1nseA-5lskN:
undetectable
1nseB-5lskN:
undetectable		 1nseA-5lskN:
19.05
1nseB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.14A 1nseA-5lskN:
undetectable
1nseB-5lskN:
undetectable		 1nseA-5lskN:
19.05
1nseB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
ARG P  16
ILE N 122
 None
 1.24A 1nsiA-5lskN:
undetectable
1nsiB-5lskN:
undetectable		 1nsiA-5lskN:
19.61
1nsiB-5lskN:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6M_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 1p6mA-5lskN:
undetectable
1p6mB-5lskN:
undetectable		 1p6mA-5lskN:
19.85
1p6mB-5lskN:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6N_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.14A 1p6nA-5lskN:
undetectable
1p6nB-5lskN:
3.1		 1p6nA-5lskN:
19.85
1p6nB-5lskN:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.12A 1rs8A-5lskN:
undetectable
1rs8B-5lskN:
3.0		 1rs8A-5lskN:
19.85
1rs8B-5lskN:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS8_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.11A 1rs8A-5lskN:
undetectable
1rs8B-5lskN:
3.0		 1rs8A-5lskN:
19.85
1rs8B-5lskN:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS9_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.16A 1rs9A-5lskN:
3.2
1rs9B-5lskN:
undetectable		 1rs9A-5lskN:
19.85
1rs9B-5lskN:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.84A 1v54C-5lskA:
2.7
1v54J-5lskA:
2.7		 1v54C-5lskA:
21.82
1v54J-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.85A 1v54P-5lskA:
undetectable
1v54W-5lskA:
2.7		 1v54P-5lskA:
21.82
1v54W-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.86A 2dyrC-5lskA:
2.3
2dyrJ-5lskA:
2.7		 2dyrC-5lskA:
21.82
2dyrJ-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.84A 2dyrP-5lskA:
undetectable
2dyrW-5lskA:
2.7		 2dyrP-5lskA:
21.82
2dyrW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.90A 2eikC-5lskA:
3.3
2eikJ-5lskA:
2.7		 2eikC-5lskA:
21.82
2eikJ-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.89A 2eikP-5lskA:
3.3
2eikW-5lskA:
2.8		 2eikP-5lskA:
21.82
2eikW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.91A 2eilC-5lskA:
2.7
2eilJ-5lskA:
2.7		 2eilC-5lskA:
21.82
2eilJ-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.89A 2eimP-5lskA:
undetectable
2eimW-5lskA:
2.7		 2eimP-5lskA:
21.82
2eimW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HX2_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.13A 2hx2A-5lskN:
undetectable
2hx2B-5lskN:
undetectable		 2hx2A-5lskN:
19.85
2hx2B-5lskN:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSE_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.16A 2nseA-5lskN:
undetectable
2nseB-5lskN:
undetectable		 2nseA-5lskN:
19.05
2nseB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.88A 3abkP-5lskA:
2.7
3abkW-5lskA:
2.7		 3abkP-5lskA:
21.82
3abkW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.90A 3ag2C-5lskA:
undetectable		 3ag2C-5lskA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.88A 3ag2P-5lskA:
2.7
3ag2W-5lskA:
2.7		 3ag2P-5lskA:
21.82
3ag2W-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 8 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.85A 3ag4C-5lskA:
undetectable
3ag4J-5lskA:
2.7		 3ag4C-5lskA:
21.82
3ag4J-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.83A 3ag4P-5lskA:
3.2
3ag4W-5lskA:
2.7		 3ag4P-5lskA:
21.82
3ag4W-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.86A 3asnC-5lskA:
undetectable
3asnJ-5lskA:
2.7		 3asnC-5lskA:
21.82
3asnJ-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.87A 3asnP-5lskA:
undetectable
3asnW-5lskA:
2.7		 3asnP-5lskA:
21.82
3asnW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.83A 3asoP-5lskA:
2.3
3asoW-5lskA:
2.6		 3asoP-5lskA:
21.82
3asoW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 5lsk POLYAMINE-MODULATED
FACTOR 1
PROTEIN MIS12
HOMOLOG
(Homo
sapiens) 		4 / 8 LEU A 138
ALA B 168
LEU B 167
GLN B 161
 None
 0.80A 3cldB-5lskA:
undetectable		 3cldB-5lskA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.11A 3dqsA-5lskN:
3.1
3dqsB-5lskN:
undetectable		 3dqsA-5lskN:
19.85
3dqsB-5lskN:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.12A 3dqsA-5lskN:
3.1
3dqsB-5lskN:
undetectable		 3dqsA-5lskN:
19.85
3dqsB-5lskN:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.14A 3dqtA-5lskN:
undetectable
3dqtB-5lskN:
3.0		 3dqtA-5lskN:
19.85
3dqtB-5lskN:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 3dqtA-5lskN:
undetectable
3dqtB-5lskN:
3.0		 3dqtA-5lskN:
19.85
3dqtB-5lskN:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.14A 3jwyA-5lskN:
undetectable
3jwyB-5lskN:
3.1		 3jwyA-5lskN:
19.05
3jwyB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 3jwyA-5lskN:
undetectable
3jwyB-5lskN:
3.1		 3jwyA-5lskN:
19.05
3jwyB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.11A 3jwzA-5lskN:
3.1
3jwzB-5lskN:
undetectable		 3jwzA-5lskN:
19.05
3jwzB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.11A 3jwzA-5lskN:
3.1
3jwzB-5lskN:
undetectable		 3jwzA-5lskN:
19.05
3jwzB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.15A 3jx2A-5lskN:
undetectable
3jx2B-5lskN:
undetectable		 3jx2A-5lskN:
19.26
3jx2B-5lskN:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.14A 3n5rA-5lskN:
undetectable
3n5rB-5lskN:
undetectable		 3n5rA-5lskN:
19.05
3n5rB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5R_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.12A 3n5rA-5lskN:
undetectable
3n5rB-5lskN:
undetectable		 3n5rA-5lskN:
19.05
3n5rB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5T_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.10A 3n5tA-5lskN:
undetectable
3n5tB-5lskN:
undetectable		 3n5tA-5lskN:
19.05
3n5tB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLF_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.14A 3nlfA-5lskN:
undetectable
3nlfB-5lskN:
2.9		 3nlfA-5lskN:
19.05
3nlfB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLG_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.17A 3nlgA-5lskN:
undetectable
3nlgB-5lskN:
3.0		 3nlgA-5lskN:
19.05
3nlgB-5lskN:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NOS_B_H4BB1011_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.16A 3nosA-5lskN:
2.5
3nosB-5lskN:
2.5		 3nosA-5lskN:
20.64
3nosB-5lskN:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 PHE A  67
PHE A  70
GLY B  53
THR B  59
 None
 1.15A 3vnsA-5lskA:
undetectable		 3vnsA-5lskA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.85A 3wg7C-5lskA:
3.1
3wg7J-5lskA:
2.7		 3wg7C-5lskA:
21.82
3wg7J-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.87A 3x2qC-5lskA:
3.3
3x2qJ-5lskA:
2.7		 3x2qC-5lskA:
21.82
3x2qJ-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.85A 3x2qP-5lskA:
undetectable
3x2qW-5lskA:
2.7		 3x2qP-5lskA:
21.82
3x2qW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.16A 4c3aA-5lskN:
undetectable
4c3aB-5lskN:
undetectable		 4c3aA-5lskN:
19.09
4c3aB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 4c3aA-5lskN:
undetectable
4c3aB-5lskN:
undetectable		 4c3aA-5lskN:
19.09
4c3aB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAR_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.15A 4carA-5lskN:
undetectable
4carB-5lskN:
undetectable		 4carA-5lskN:
19.09
4carB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.16A 4cftA-5lskN:
undetectable
4cftB-5lskN:
undetectable		 4cftA-5lskN:
19.09
4cftB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CFT_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.15A 4cftA-5lskN:
undetectable
4cftB-5lskN:
undetectable		 4cftA-5lskN:
19.09
4cftB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.10A 4ctyA-5lskN:
undetectable
4ctyB-5lskN:
3.0		 4ctyA-5lskN:
19.09
4ctyB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CU1_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.16A 4cu1A-5lskN:
3.0
4cu1B-5lskN:
undetectable		 4cu1A-5lskN:
19.09
4cu1B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.10A 4cwvA-5lskN:
undetectable
4cwvB-5lskN:
3.0		 4cwvA-5lskN:
19.09
4cwvB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWV_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.09A 4cwvA-5lskN:
undetectable
4cwvB-5lskN:
3.0		 4cwvA-5lskN:
19.09
4cwvB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.12A 4cwwA-5lskN:
undetectable
4cwwB-5lskN:
undetectable		 4cwwA-5lskN:
19.09
4cwwB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWW_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.15A 4cwwA-5lskN:
undetectable
4cwwB-5lskN:
undetectable		 4cwwA-5lskN:
19.09
4cwwB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.17A 4cwxA-5lskN:
undetectable
4cwxB-5lskN:
3.1		 4cwxA-5lskN:
19.09
4cwxB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWX_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 4cwxA-5lskN:
undetectable
4cwxB-5lskN:
3.1		 4cwxA-5lskN:
19.09
4cwxB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.18A 4cwyA-5lskN:
3.0
4cwyB-5lskN:
3.0		 4cwyA-5lskN:
19.09
4cwyB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.14A 4cwyA-5lskN:
3.0
4cwyB-5lskN:
3.0		 4cwyA-5lskN:
19.09
4cwyB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.14A 4cwzA-5lskN:
undetectable
4cwzB-5lskN:
undetectable		 4cwzA-5lskN:
19.09
4cwzB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CWZ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.15A 4cwzA-5lskN:
undetectable
4cwzB-5lskN:
undetectable		 4cwzA-5lskN:
19.09
4cwzB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_A_H4BA1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.14A 4d1oA-5lskN:
undetectable
4d1oB-5lskN:
undetectable		 4d1oA-5lskN:
20.23
4d1oB-5lskN:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1O_B_H4BB1481_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 4d1oA-5lskN:
undetectable
4d1oB-5lskN:
undetectable		 4d1oA-5lskN:
20.23
4d1oB-5lskN:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D34_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.07A 4d34A-5lskN:
undetectable
4d34B-5lskN:
undetectable		 4d34A-5lskN:
19.09
4d34B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D35_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.09A 4d35A-5lskN:
undetectable
4d35B-5lskN:
undetectable		 4d35A-5lskN:
19.09
4d35B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.16A 4d36A-5lskN:
2.6
4d36B-5lskN:
2.5		 4d36A-5lskN:
19.09
4d36B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D36_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.14A 4d36A-5lskN:
2.6
4d36B-5lskN:
2.5		 4d36A-5lskN:
19.09
4d36B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D37_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.11A 4d37A-5lskN:
undetectable
4d37B-5lskN:
undetectable		 4d37A-5lskN:
19.09
4d37B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D38_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.14A 4d38A-5lskN:
undetectable
4d38B-5lskN:
undetectable		 4d38A-5lskN:
19.09
4d38B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.16A 4d39A-5lskN:
2.6
4d39B-5lskN:
undetectable		 4d39A-5lskN:
19.09
4d39B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.16A 4d39A-5lskN:
2.6
4d39B-5lskN:
undetectable		 4d39A-5lskN:
19.09
4d39B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D3A_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 4d3aA-5lskN:
undetectable
4d3aB-5lskN:
undetectable		 4d3aA-5lskN:
19.09
4d3aB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
CENTROMERE PROTEIN C
(Homo
sapiens;
Homo
sapiens) 		3 / 3 PHE N 115
ASP N 113
ARG P  15
 None
 0.81A 4eahF-5lskN:
undetectable		 4eahF-5lskN:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
CENTROMERE PROTEIN C
(Homo
sapiens;
Homo
sapiens) 		3 / 3 PHE N 115
ASP N 113
ARG P  15
 None
 0.81A 4eahG-5lskN:
undetectable		 4eahG-5lskN:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG
(Homo
sapiens) 		3 / 3 LYS D 176
LEU D 139
ALA D 179
 None
 0.84A 4iizA-5lskD:
undetectable		 4iizA-5lskD:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_A_H4BA502_1
(SUBUNIT A)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.15A 4imxA-5lskN:
undetectable
4imxB-5lskN:
undetectable		 4imxA-5lskN:
19.13
4imxB-5lskN:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMX_B_H4BB502_1
(SUBUNIT A)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.12A 4imxA-5lskN:
undetectable
4imxB-5lskN:
undetectable		 4imxA-5lskN:
19.13
4imxB-5lskN:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSM_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.11A 4jsmA-5lskN:
2.5
4jsmB-5lskN:
undetectable		 4jsmA-5lskN:
19.09
4jsmB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.15A 4k5hA-5lskN:
undetectable
4k5hB-5lskN:
3.0		 4k5hA-5lskN:
19.09
4k5hB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5H_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 4k5hA-5lskN:
undetectable
4k5hB-5lskN:
3.0		 4k5hA-5lskN:
19.09
4k5hB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 4k5jA-5lskN:
undetectable
4k5jB-5lskN:
undetectable		 4k5jA-5lskN:
19.09
4k5jB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5K_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.17A 4k5kA-5lskN:
3.1
4k5kB-5lskN:
undetectable		 4k5kA-5lskN:
19.09
4k5kB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.15A 4kcpA-5lskN:
undetectable
4kcpB-5lskN:
2.9		 4kcpA-5lskN:
19.09
4kcpB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCP_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.14A 4kcpA-5lskN:
undetectable
4kcpB-5lskN:
2.9		 4kcpA-5lskN:
19.09
4kcpB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCQ_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.17A 4kcqA-5lskN:
3.1
4kcqB-5lskN:
undetectable		 4kcqA-5lskN:
19.09
4kcqB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.14A 4kcrA-5lskN:
2.6
4kcrB-5lskN:
undetectable		 4kcrA-5lskN:
19.09
4kcrB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCR_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.16A 4kcrA-5lskN:
2.6
4kcrB-5lskN:
undetectable		 4kcrA-5lskN:
19.09
4kcrB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.12A 4kcsA-5lskN:
2.6
4kcsB-5lskN:
undetectable		 4kcsA-5lskN:
19.09
4kcsB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCS_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.15A 4kcsA-5lskN:
2.6
4kcsB-5lskN:
undetectable		 4kcsA-5lskN:
19.09
4kcsB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUW_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.11A 4luwA-5lskN:
undetectable
4luwB-5lskN:
undetectable		 4luwA-5lskN:
19.13
4luwB-5lskN:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens;
Homo
sapiens) 		3 / 3 PHE N  80
THR D 187
LEU D 175
 None
 0.62A 4qztA-5lskN:
undetectable		 4qztA-5lskN:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.20A 4uh8A-5lskN:
undetectable
4uh8B-5lskN:
undetectable		 4uh8A-5lskN:
19.09
4uh8B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH8_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.15A 4uh8A-5lskN:
undetectable
4uh8B-5lskN:
undetectable		 4uh8A-5lskN:
19.09
4uh8B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.16A 4uh9A-5lskN:
3.0
4uh9B-5lskN:
undetectable		 4uh9A-5lskN:
19.09
4uh9B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH9_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.12A 4uh9A-5lskN:
3.0
4uh9B-5lskN:
undetectable		 4uh9A-5lskN:
19.09
4uh9B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHA_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.19A 4uhaA-5lskN:
undetectable
4uhaB-5lskN:
undetectable		 4uhaA-5lskN:
19.09
4uhaB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPQ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.17A 4upqA-5lskN:
undetectable
4upqB-5lskN:
undetectable		 4upqA-5lskN:
19.09
4upqB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 PHE A 174
LEU B 190
SER A 172
PHE A 159
 None
 1.06A 4wnvD-5lskA:
undetectable		 4wnvD-5lskA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADJ_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.14A 5adjA-5lskN:
undetectable
5adjB-5lskN:
undetectable		 5adjA-5lskN:
19.09
5adjB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.16A 5adkA-5lskN:
undetectable
5adkB-5lskN:
undetectable		 5adkA-5lskN:
19.09
5adkB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADK_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.16A 5adkA-5lskN:
undetectable
5adkB-5lskN:
undetectable		 5adkA-5lskN:
19.09
5adkB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_A_H4BA600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.17A 5adlA-5lskN:
undetectable
5adlB-5lskN:
2.5		 5adlA-5lskN:
19.09
5adlB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.18A 5adlA-5lskN:
undetectable
5adlB-5lskN:
2.5		 5adlA-5lskN:
19.09
5adlB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADM_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.16A 5admA-5lskN:
undetectable
5admB-5lskN:
3.0		 5admA-5lskN:
19.09
5admB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.12A 5adnA-5lskN:
undetectable
5adnB-5lskN:
undetectable		 5adnA-5lskN:
19.09
5adnB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADN_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.11A 5adnA-5lskN:
undetectable
5adnB-5lskN:
undetectable		 5adnA-5lskN:
19.09
5adnB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ2_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.14A 5fj2A-5lskN:
undetectable
5fj2B-5lskN:
undetectable		 5fj2A-5lskN:
19.09
5fj2B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 5fj3A-5lskN:
undetectable
5fj3B-5lskN:
3.0		 5fj3A-5lskN:
19.09
5fj3B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVY_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 5fvyA-5lskN:
undetectable
5fvyB-5lskN:
undetectable		 5fvyA-5lskN:
19.09
5fvyB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 5lsk PROTEIN MIS12
HOMOLOG
CENTROMERE PROTEIN C
(Homo
sapiens;
Homo
sapiens) 		4 / 5 PHE A  79
SER A  80
ASN P  11
GLN A  29
 None
 1.13A 5kpcA-5lskA:
undetectable		 5kpcA-5lskA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.11A 5uo8A-5lskN:
0.0
5uo8B-5lskN:
undetectable		 5uo8A-5lskN:
20.23
5uo8B-5lskN:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.11A 5uo8C-5lskN:
undetectable
5uo8D-5lskN:
undetectable		 5uo8C-5lskN:
20.23
5uo8D-5lskN:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.12A 5uo9A-5lskN:
0.0
5uo9B-5lskN:
0.0		 5uo9A-5lskN:
20.23
5uo9B-5lskN:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.12A 5uo9A-5lskN:
undetectable
5uo9B-5lskN:
undetectable		 5uo9A-5lskN:
20.23
5uo9B-5lskN:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.17A 5uo9C-5lskN:
undetectable
5uo9D-5lskN:
undetectable		 5uo9C-5lskN:
20.23
5uo9D-5lskN:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UOD_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.15A 5uodA-5lskN:
undetectable
5uodB-5lskN:
undetectable		 5uodA-5lskN:
19.09
5uodB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.15A 5vv6A-5lskN:
undetectable
5vv6B-5lskN:
undetectable		 5vv6A-5lskN:
19.09
5vv6B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV6_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 5vv6A-5lskN:
undetectable
5vv6B-5lskN:
undetectable		 5vv6A-5lskN:
19.09
5vv6B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.15A 5vv8A-5lskN:
undetectable
5vv8B-5lskN:
undetectable		 5vv8A-5lskN:
19.09
5vv8B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV9_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.12A 5vv9A-5lskN:
undetectable
5vv9B-5lskN:
3.0		 5vv9A-5lskN:
19.09
5vv9B-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.12A 5vvbC-5lskN:
undetectable
5vvbD-5lskN:
undetectable		 5vvbC-5lskN:
20.23
5vvbD-5lskN:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVC_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.10A 5vvcA-5lskN:
0.0
5vvcB-5lskN:
undetectable		 5vvcA-5lskN:
20.23
5vvcB-5lskN:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVD_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.09A 5vvdA-5lskN:
0.3
5vvdB-5lskN:
undetectable		 5vvdA-5lskN:
20.23
5vvdB-5lskN:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.16A 5vvgA-5lskN:
2.6
5vvgB-5lskN:
undetectable		 5vvgA-5lskN:
19.09
5vvgB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVG_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.14A 5vvgA-5lskN:
2.5
5vvgB-5lskN:
undetectable		 5vvgA-5lskN:
19.09
5vvgB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.15A 5vvnA-5lskN:
undetectable
5vvnB-5lskN:
undetectable		 5vvnA-5lskN:
19.09
5vvnB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.14A 5vvnA-5lskN:
undetectable
5vvnB-5lskN:
undetectable		 5vvnA-5lskN:
19.09
5vvnB-5lskN:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 6 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.82A 5x19P-5lskA:
3.1		 5x19P-5lskA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 5 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.84A 5x1bP-5lskA:
3.2		 5x1bP-5lskA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.82A 5x1fP-5lskA:
3.3
5x1fW-5lskA:
2.7		 5x1fP-5lskA:
21.82
5x1fW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.87A 5z85C-5lskA:
undetectable
5z85J-5lskA:
2.7		 5z85C-5lskA:
21.82
5z85J-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.83A 5zcoC-5lskA:
2.4
5zcoJ-5lskA:
2.7		 5zcoC-5lskA:
21.82
5zcoJ-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.87A 5zcqC-5lskA:
undetectable
5zcqJ-5lskA:
2.6		 5zcqC-5lskA:
21.82
5zcqJ-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.88A 5zcqP-5lskA:
undetectable
5zcqW-5lskA:
undetectable		 5zcqP-5lskA:
21.82
5zcqW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
(Homo
sapiens;
Homo
sapiens) 		4 / 5 ASP B  39
ILE B  88
PHE A  28
ASN B 100
 None
 1.24A 6a93B-5lskB:
undetectable		 6a93B-5lskB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 7 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.15A 6av7A-5lskN:
undetectable
6av7B-5lskN:
undetectable		 6av7A-5lskN:
16.49
6av7B-5lskN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.11A 6av7A-5lskN:
0.0
6av7B-5lskN:
undetectable		 6av7A-5lskN:
16.49
6av7B-5lskN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.16A 6av7C-5lskN:
undetectable
6av7D-5lskN:
undetectable		 6av7C-5lskN:
16.49
6av7D-5lskN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_A_H4BA502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
CENTROMERE PROTEIN C
(Homo
sapiens;
Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.09A 6cieA-5lskN:
undetectable
6cieB-5lskN:
undetectable		 6cieA-5lskN:
16.49
6cieB-5lskN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
CENTROMERE PROTEIN C
(Homo
sapiens;
Homo
sapiens) 		4 / 7 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.10A 6cieA-5lskN:
undetectable
6cieB-5lskN:
undetectable		 6cieA-5lskN:
16.49
6cieB-5lskN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
CENTROMERE PROTEIN C
(Homo
sapiens;
Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.11A 6cieC-5lskN:
undetectable
6cieD-5lskN:
undetectable		 6cieC-5lskN:
16.49
6cieD-5lskN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
CENTROMERE PROTEIN C
(Homo
sapiens;
Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.14A 6cieC-5lskN:
undetectable
6cieD-5lskN:
undetectable		 6cieC-5lskN:
16.49
6cieD-5lskN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_A_H4BA502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
CENTROMERE PROTEIN C
(Homo
sapiens;
Homo
sapiens) 		4 / 6 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.15A 6cifA-5lskN:
undetectable
6cifB-5lskN:
undetectable		 6cifA-5lskN:
16.49
6cifB-5lskN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
CENTROMERE PROTEIN C
(Homo
sapiens;
Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.13A 6cifA-5lskN:
undetectable
6cifB-5lskN:
undetectable		 6cifA-5lskN:
16.49
6cifB-5lskN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
CENTROMERE PROTEIN C
(Homo
sapiens;
Homo
sapiens) 		4 / 7 VAL N 120
ARG P  16
PHE N 115
GLU N 117
 None
 1.12A 6cifC-5lskN:
undetectable
6cifD-5lskN:
undetectable		 6cifC-5lskN:
16.49
6cifD-5lskN:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 5lsk KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU N  52
PHE D 178
ASP D 180
GLY D 181
ASP D 185
 None
 1.27A 6dwnA-5lskN:
undetectable		 6dwnA-5lskN:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYN_A_HSMA901_0
(EBONY)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		4 / 4 GLU A 141
VAL B 166
LEU B 167
THR D 270
 None
 1.29A 6dynA-5lskA:
undetectable		 6dynA-5lskA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1
KINETOCHORE-ASSOCIAT
ED PROTEIN DSN1
HOMOLOG
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		4 / 5 GLU A 141
VAL B 166
LEU B 167
THR D 270
 None
 1.32A 6dyoA-5lskA:
undetectable		 6dyoA-5lskA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9NSE_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 5lsk CENTROMERE PROTEIN C
KINETOCHORE-ASSOCIAT
ED PROTEIN NSL1
HOMOLOG
(Homo
sapiens) 		4 / 6 PHE N 115
GLU N 117
VAL N 120
ARG P  16
 None
 1.09A 9nseA-5lskN:
undetectable
9nseB-5lskN:
undetectable		 9nseA-5lskN:
19.05
9nseB-5lskN:
19.05