SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lsm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		4 / 8 ALA A 226
GLY A 216
ALA A 227
THR A 197
 None
FMN  A 401 (-3.5A)
None
None
 0.67A 1gtnI-5lsmA:
undetectable
1gtnJ-5lsmA:
undetectable		 1gtnI-5lsmA:
10.86
1gtnJ-5lsmA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 9 ALA A 155
VAL A 212
GLY A 176
PRO A 202
ILE A 204
 None
 1.10A 1hpvB-5lsmA:
undetectable		 1hpvB-5lsmA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 12 ILE A  66
GLY A  39
ILE A  11
GLU A  54
ALA A  18
 None
None
None
None
FMN  A 401 (-3.4A)
 1.00A 1nv8B-5lsmA:
undetectable		 1nv8B-5lsmA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 12 ILE A  66
GLY A  39
ILE A  11
GLU A  54
ALA A  18
 None
None
None
None
FMN  A 401 (-3.4A)
 0.95A 1vq1B-5lsmA:
undetectable		 1vq1B-5lsmA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 9 LEU A   5
ILE A 213
PHE A   9
LEU A  38
ILE A  11
 None
 1.19A 2f78B-5lsmA:
undetectable		 2f78B-5lsmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 9 LEU A   5
ILE A 213
PHE A   9
LEU A  38
ILE A  11
 None
 1.05A 2f7aA-5lsmA:
undetectable		 2f7aA-5lsmA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 12 GLY A 176
GLY A 216
GLY A 325
THR A 197
LEU A 201
 None
FMN  A 401 (-3.5A)
FMN  A 401 ( 4.1A)
None
None
 1.01A 2oxtA-5lsmA:
undetectable		 2oxtA-5lsmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 11 ALA A 215
ALA A 174
GLY A 196
GLY A 217
ILE A 218
 FMN  A 401 ( 4.0A)
None
None
FMN  A 401 (-3.6A)
None
 1.13A 2x1lC-5lsmA:
undetectable		 2x1lC-5lsmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 9 THR A 265
ILE A 279
GLY A 278
GLY A 180
HIS A 253
 None
None
None
FMN  A 401 (-3.7A)
None
 1.15A 2y7wA-5lsmA:
undetectable		 2y7wA-5lsmA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 9 THR A 265
ILE A 279
GLY A 278
GLY A 325
HIS A 253
 None
None
None
FMN  A 401 ( 4.1A)
None
 1.26A 2y7wA-5lsmA:
undetectable		 2y7wA-5lsmA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 10 THR A 265
ILE A 279
GLY A 278
GLY A 180
HIS A 253
 None
None
None
FMN  A 401 (-3.7A)
None
 1.15A 2y7wB-5lsmA:
undetectable		 2y7wB-5lsmA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 10 THR A 265
ILE A 279
GLY A 278
GLY A 325
HIS A 253
 None
None
None
FMN  A 401 ( 4.1A)
None
 1.25A 2y7wB-5lsmA:
undetectable		 2y7wB-5lsmA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		4 / 5 GLN A 326
THR A 156
HIS A 185
LEU A 191
 None
 1.23A 2zj0A-5lsmA:
undetectable		 2zj0A-5lsmA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		4 / 5 GLN A 326
THR A 156
HIS A 185
LEU A 191
 None
 1.15A 3ce6A-5lsmA:
undetectable		 3ce6A-5lsmA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		4 / 5 GLN A 326
THR A 156
HIS A 185
LEU A 191
 None
 1.15A 3ce6C-5lsmA:
undetectable		 3ce6C-5lsmA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 12 ILE A  16
VAL A  68
PHE A  70
SER A 149
ILE A 144
 None
 1.13A 3iw1A-5lsmA:
undetectable		 3iw1A-5lsmA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		6 / 12 ILE A 152
ALA A 214
PRO A  19
ALA A  18
ILE A 172
ALA A 155
 None
None
FMN  A 401 (-4.5A)
FMN  A 401 (-3.4A)
None
None
 1.30A 3jb1A-5lsmA:
undetectable		 3jb1A-5lsmA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 10 ALA A 155
VAL A 212
GLY A 176
PRO A 202
ILE A 204
 None
 1.10A 3oxvB-5lsmA:
undetectable		 3oxvB-5lsmA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 10 ALA A  35
PHE A  13
GLY A  37
ILE A  15
CYH A 247
 None
 1.47A 3qpsA-5lsmA:
undetectable		 3qpsA-5lsmA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		4 / 8 VAL A  32
VAL A 128
ILE A  16
GLN A  17
 None
 1.01A 3remA-5lsmA:
undetectable		 3remA-5lsmA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		4 / 8 VAL A  32
VAL A 128
ILE A  16
GLN A  17
 None
 0.96A 3remB-5lsmA:
undetectable		 3remB-5lsmA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 9 ALA A 155
VAL A 212
GLY A 176
PRO A 202
ILE A 204
 None
 1.20A 4ll3B-5lsmA:
undetectable		 4ll3B-5lsmA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		5 / 9 THR A 223
ALA A 227
ALA A 232
GLY A 217
GLY A 216
 None
None
None
FMN  A 401 (-3.6A)
FMN  A 401 (-3.5A)
 1.14A 4qwuY-5lsmA:
undetectable
4qwuZ-5lsmA:
undetectable		 4qwuY-5lsmA:
20.22
4qwuZ-5lsmA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5lsm FMN-DEPENDENT
NITRONATE
MONOOXYGENASE
(Shewanella
oneidensis) 		3 / 3 ALA A  35
GLN A  17
THR A 340
 None
 0.69A 5n0oA-5lsmA:
undetectable		 5n0oA-5lsmA:
23.06