SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lsp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 ASP A 587
PHE A 588
LEU A 598
 None
 0.59A 2zi9A-5lspA:
undetectable		 2zi9A-5lspA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 4 LEU A 675
GLN A 714
THR A 711
THR A 733
 None
 1.49A 2zj0D-5lspA:
undetectable		 2zj0D-5lspA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 SER A 525
ASP A 587
ASN A 642
 None
 0.95A 3lslA-5lspA:
undetectable
3lslD-5lspA:
undetectable		 3lslA-5lspA:
20.93
3lslD-5lspA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 4 LEU A 604
GLY A 606
LEU A 605
GLU A 608
 None
 0.92A 3tgvB-5lspA:
undetectable		 3tgvB-5lspA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 4 ASN A 686
VAL A 626
THR A 582
ILE A 583
 None
 1.44A 4retA-5lspA:
undetectable		 4retA-5lspA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 4 ASN A 686
VAL A 626
THR A 582
ILE A 583
 None
 1.44A 4retC-5lspA:
undetectable		 4retC-5lspA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 7 THR A 613
LEU A 612
THR A 582
THR A 621
 None
 0.96A 4z91F-5lspA:
undetectable
4z91G-5lspA:
undetectable
4z91H-5lspA:
undetectable
4z91I-5lspA:
undetectable
4z91J-5lspA:
undetectable		 4z91F-5lspA:
19.88
4z91G-5lspA:
19.88
4z91H-5lspA:
19.88
4z91I-5lspA:
19.88
4z91J-5lspA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 8 GLY A 679
ILE A 659
ASP A 656
PRO A 574
 None
 0.96A 6ag0C-5lspA:
undetectable		 6ag0C-5lspA:
17.19