SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 HIS A 930
ILE A1051
LEU A 923
VAL A 842
ALA A 841
 None
 0.99A 1axwA-5lstA:
undetectable		 1axwA-5lstA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_A_DXCA801_0
(STEROID
DELTA-ISOMERASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 PHE A1108
TYR A1107
GLY A1105
PHE A1077
LEU A 676
 None
 0.96A 1e3vA-5lstA:
undetectable		 1e3vA-5lstA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E3V_B_DXCB801_0
(STEROID
DELTA-ISOMERASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 11 PHE A1108
TYR A1107
GLY A1105
PHE A1077
LEU A 676
 None
 0.94A 1e3vB-5lstA:
undetectable		 1e3vB-5lstA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		6 / 12 LEU A 493
LEU A 462
ALA A 463
VAL A 658
CYH A 636
LEU A 638
 None
 1.50A 1fm9A-5lstA:
undetectable		 1fm9A-5lstA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 PHE A 470
LEU A 514
VAL A 489
PHE A 481
ALA A 463
 None
 1.14A 1q23A-5lstA:
undetectable
1q23B-5lstA:
undetectable		 1q23A-5lstA:
14.57
1q23B-5lstA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 HIS A 930
ILE A1051
LEU A 923
VAL A 842
ALA A 841
 None
 0.99A 1tlsA-5lstA:
undetectable		 1tlsA-5lstA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 HIS A 930
ILE A1051
LEU A 923
VAL A 842
ALA A 841
 None
 1.04A 1tlsB-5lstA:
undetectable		 1tlsB-5lstA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 HIS A 930
ILE A1051
LEU A 923
VAL A 842
ALA A 841
 None
 0.97A 1tsnA-5lstA:
undetectable		 1tsnA-5lstA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 LEU A 628
VAL A 634
GLY A 633
LEU A 584
LEU A 590
 None
 0.89A 2egvA-5lstA:
undetectable		 2egvA-5lstA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 LEU A 628
VAL A 634
GLY A 633
LEU A 584
LEU A 590
 None
 0.89A 2egvB-5lstA:
undetectable		 2egvB-5lstA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 LEU A 700
ASN A 699
VAL A 767
ARG A 780
LEU A 692
 None
 1.28A 2q7kA-5lstA:
undetectable		 2q7kA-5lstA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 LEU A 720
ILE A 705
THR A 684
ASP A 685
HIS A 815
 None
 1.29A 2qo6A-5lstA:
undetectable		 2qo6A-5lstA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 ALA A 551
LEU A 577
ILE A 604
LEU A 584
PRO A 591
 None
 1.15A 2qxsA-5lstA:
undetectable		 2qxsA-5lstA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 LEU A 937
ALA A 587
VAL A 627
LEU A 596
LEU A 577
 None
 1.11A 3b0wB-5lstA:
undetectable		 3b0wB-5lstA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR4_X_PNTX101_0
(PROTEIN S100-B)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		3 / 3 CYH A 636
HIS A 635
PHE A 637
 None
 1.15A 3cr4X-5lstA:
undetectable		 3cr4X-5lstA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 10 ILE A 703
ILE A 705
TYR A 798
PRO A 792
LEU A 691
 None
 1.36A 3elzB-5lstA:
undetectable		 3elzB-5lstA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		3 / 3 ASP A 824
PHE A1074
SER A 679
 None
 0.82A 3i5uB-5lstA:
3.3		 3i5uB-5lstA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 ARG A 629
TYR A 621
HIS A 608
THR A 643
ILE A 604
 None
 1.34A 3lcvB-5lstA:
undetectable		 3lcvB-5lstA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		4 / 7 PRO A 597
LEU A 528
LEU A 579
ILE A 569
 None
 1.04A 3u5jA-5lstA:
undetectable		 3u5jA-5lstA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 10 LEU A 845
ARG A 623
MET A 915
GLU A 921
VAL A 910
 None
 1.49A 3ua5B-5lstA:
undetectable		 3ua5B-5lstA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 HIS A 930
ILE A1051
LEU A 923
VAL A 842
ALA A 841
 None
 1.02A 4fqsA-5lstA:
undetectable		 4fqsA-5lstA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 HIS A 930
ILE A1051
LEU A 923
VAL A 842
ALA A 841
 None
 1.02A 4fqsB-5lstA:
undetectable		 4fqsB-5lstA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		4 / 4 TYR A 621
THR A 580
VAL A 585
ILE A 604
 None
 1.38A 4jx1F-5lstA:
undetectable		 4jx1F-5lstA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		4 / 6 GLU A 752
ARG A 753
ASP A 538
ARG A 754
 None
 1.39A 4kcnA-5lstA:
undetectable		 4kcnA-5lstA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		3 / 3 VAL A 846
GLN A1050
CYH A1052
 None
 0.71A 5icxA-5lstA:
undetectable
5icxE-5lstA:
undetectable		 5icxA-5lstA:
14.33
5icxE-5lstA:
3.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		4 / 8 VAL A 634
GLY A 639
LEU A 656
THR A 498
 None
 1.03A 5sxqB-5lstA:
undetectable		 5sxqB-5lstA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		4 / 8 VAL A 634
GLY A 639
LEU A 656
THR A 498
 None
 1.03A 5syjA-5lstA:
undetectable		 5syjA-5lstA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 VAL A 783
ASP A 782
LEU A 720
ALA A 785
LEU A 692
 None
 1.10A 6ew0B-5lstA:
undetectable		 6ew0B-5lstA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 VAL A 783
ASP A 782
LEU A 720
ALA A 785
LEU A 692
 None
 1.10A 6ew0D-5lstA:
undetectable		 6ew0D-5lstA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 VAL A 783
ASP A 782
LEU A 720
ALA A 785
LEU A 692
 None
 1.10A 6ew0F-5lstA:
undetectable		 6ew0F-5lstA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_1
(TUBULIN BETA CHAIN)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 VAL A 783
ASP A 782
LEU A 720
ALA A 785
LEU A 692
 None
 1.10A 6ew0G-5lstA:
undetectable		 6ew0G-5lstA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 VAL A 783
ASP A 782
LEU A 720
ALA A 785
LEU A 692
 None
 1.10A 6ew0H-5lstA:
undetectable		 6ew0H-5lstA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 5lst ATP-DEPENDENT DNA
HELICASE Q4
(Homo
sapiens) 		5 / 12 VAL A 783
ASP A 782
LEU A 720
ALA A 785
LEU A 692
 None
 1.10A 6ew0I-5lstA:
undetectable		 6ew0I-5lstA:
7.79