SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lsu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		4 / 5 LEU A1163
VAL A1161
TYR A1092
THR A1150
 None
 1.32A 1nw3A-5lsuA:
undetectable		 1nw3A-5lsuA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		3 / 3 GLY A1157
GLU A1012
ASP A1158
 None
 0.68A 2b25B-5lsuA:
undetectable		 2b25B-5lsuA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		4 / 7 LEU A1163
PHE A1088
THR A1065
ILE A1067
 None
 0.86A 2bdmA-5lsuA:
undetectable		 2bdmA-5lsuA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		9 / 12 ARG A1073
GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1191
CYH A1193
LEU A1202
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.49A 2r3aA-5lsuA:
20.4		 2r3aA-5lsuA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R3A_A_SAMA304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.42A 2r3aA-5lsuA:
20.4		 2r3aA-5lsuA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		4 / 7 LEU A1202
TYR A1179
ILE A1106
ARG A1126
 SAM  A1304 ( 4.7A)
SAM  A1304 (-4.1A)
None
None
 1.30A 3ik3A-5lsuA:
undetectable		 3ik3A-5lsuA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		4 / 7 LEU A1202
TYR A1179
ILE A1106
ARG A1126
 SAM  A1304 ( 4.7A)
SAM  A1304 (-4.1A)
None
None
 1.25A 3ik3B-5lsuA:
undetectable		 3ik3B-5lsuA:
21.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		10 / 12 ARG A1073
GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
LEU A1202
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.36A 3ooiA-5lsuA:
33.7		 3ooiA-5lsuA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.46A 3ooiA-5lsuA:
33.7		 3ooiA-5lsuA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.08A 3ooiA-5lsuA:
33.7		 3ooiA-5lsuA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.33A 3opeA-5lsuA:
26.6		 3opeA-5lsuA:
36.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OPE_A_SAMA7_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.43A 3opeA-5lsuA:
26.6		 3opeA-5lsuA:
36.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OPE_B_SAMB8_0
(PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 9 GLY A1074
TRP A1075
TYR A1118
ASN A1141
TYR A1179
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.1A)
 0.47A 3opeB-5lsuA:
25.2		 3opeB-5lsuA:
36.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TYR A1118
ASN A1141
HIS A1142
TYR A1179
 SAM  A1304 ( 3.2A)
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
 0.90A 3qxyA-5lsuA:
6.1		 3qxyA-5lsuA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TYR A1118
ASN A1141
HIS A1142
TYR A1179
 SAM  A1304 ( 3.2A)
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
 0.87A 3rc0B-5lsuA:
6.0		 3rc0B-5lsuA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQ4_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
 SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
 0.37A 3rq4A-5lsuA:
9.5		 3rq4A-5lsuA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
 SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
 0.39A 3s8pA-5lsuA:
9.0		 3s8pA-5lsuA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
 SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
 0.41A 4bupA-5lsuA:
8.8		 4bupA-5lsuA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		3 / 3 ARG A1060
GLU A1040
TYR A1062
 None
 0.89A 4r29D-5lsuA:
undetectable		 4r29D-5lsuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		4 / 7 GLY A1185
PHE A1117
ASN A1186
HIS A1110
 None
None
SAM  A1304 (-3.6A)
None
 1.09A 4ws0A-5lsuA:
undetectable		 4ws0A-5lsuA:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.38A 4ynmA-5lsuA:
27.8		 4ynmA-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.26A 4ynmA-5lsuA:
27.8		 4ynmA-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.33A 4ynmB-5lsuA:
25.7		 4ynmB-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.45A 4ynmB-5lsuA:
25.7		 4ynmB-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 1.44A 4ynmB-5lsuA:
25.7		 4ynmB-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.05A 4ynmB-5lsuA:
25.7		 4ynmB-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1191
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
 0.39A 4ynpA-5lsuA:
27.2		 4ynpA-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.37A 4ynpA-5lsuA:
27.2		 4ynpA-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 0.99A 4ynpA-5lsuA:
27.2		 4ynpA-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 10 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.48A 4ynpB-5lsuA:
25.0		 4ynpB-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 10 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.37A 4ynpB-5lsuA:
25.0		 4ynpB-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 10 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 1.47A 4ynpB-5lsuA:
25.0		 4ynpB-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YNP_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 10 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.11A 4ynpB-5lsuA:
25.0		 4ynpB-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.26A 4ypaA-5lsuA:
27.7		 4ypaA-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.35A 4ypaA-5lsuA:
27.7		 4ypaA-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_A_SAMA3004_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.01A 4ypaA-5lsuA:
27.7		 4ypaA-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.41A 4ypaB-5lsuA:
26.9		 4ypaB-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.24A 4ypaB-5lsuA:
26.9		 4ypaB-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.29A 4ypaC-5lsuA:
27.2		 4ypaC-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_C_SAMC2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.20A 4ypaC-5lsuA:
27.2		 4ypaC-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.44A 4ypaD-5lsuA:
26.4		 4ypaD-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPA_D_SAMD2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.38A 4ypaD-5lsuA:
26.4		 4ypaD-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.27A 4ypeA-5lsuA:
27.2		 4ypeA-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.37A 4ypeA-5lsuA:
27.2		 4ypeA-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 11 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.41A 4ypeB-5lsuA:
26.1		 4ypeB-5lsuA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.33A 4ypuA-5lsuA:
27.3		 4ypuA-5lsuA:
36.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.42A 4ypuA-5lsuA:
27.3		 4ypuA-5lsuA:
36.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 1.45A 4ypuA-5lsuA:
27.3		 4ypuA-5lsuA:
36.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.05A 4ypuA-5lsuA:
27.3		 4ypuA-5lsuA:
36.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YPU_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 11 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
 0.59A 4ypuB-5lsuA:
24.7		 4ypuB-5lsuA:
36.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 PHE A1139
HIS A1142
TYR A1179
CYH A1191
CYH A1193
 SAM  A1304 (-4.7A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
 1.41A 5cprB-5lsuA:
7.9		 5cprB-5lsuA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		4 / 6 ILE A1128
GLY A1185
ASN A1186
ILE A1127
 None
None
SAM  A1304 (-3.6A)
None
 0.91A 5j4nB-5lsuA:
undetectable		 5j4nB-5lsuA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.29A 5jhnA-5lsuA:
15.7		 5jhnA-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.25A 5jhnA-5lsuA:
15.7		 5jhnA-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.33A 5jhnB-5lsuA:
19.8		 5jhnB-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
GLN A1072
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
None
 1.15A 5jhnB-5lsuA:
19.8		 5jhnB-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.25A 5jhnB-5lsuA:
19.8		 5jhnB-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.33A 5jinA-5lsuA:
15.7		 5jinA-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.27A 5jinA-5lsuA:
15.7		 5jinA-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIN_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.24A 5jinB-5lsuA:
19.9		 5jinB-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.29A 5jiyA-5lsuA:
19.6		 5jiyA-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.20A 5jiyA-5lsuA:
19.6		 5jiyA-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.34A 5jiyB-5lsuA:
19.8		 5jiyB-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JIY_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.25A 5jiyB-5lsuA:
19.8		 5jiyB-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.32A 5jj0A-5lsuA:
15.8		 5jj0A-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.27A 5jj0A-5lsuA:
15.8		 5jj0A-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.25A 5jj0B-5lsuA:
19.8		 5jj0B-5lsuA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JJ0_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.36A 5jj0B-5lsuA:
19.8		 5jj0B-5lsuA:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		12 / 12 ARG A1073
GLY A1074
TRP A1075
HIS A1116
TYR A1118
HIS A1142
ASN A1186
THR A1189
CYH A1191
ARG A1192
CYH A1193
LEU A1202
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.4A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-3.6A)
SAM  A1304 ( 3.9A)
ZN  A1301 ( 2.3A)
None
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.04A 5lsuA-5lsuA:
39.6		 5lsuA-5lsuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		11 / 12 ARG A1073
GLY A1074
TRP A1075
HIS A1116
PHE A1117
TYR A1118
HIS A1142
ASN A1186
THR A1189
CYH A1193
LEU A1202
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.4A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-3.6A)
SAM  A1304 ( 3.9A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.40A 5lsuB-5lsuA:
36.4		 5lsuB-5lsuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
HIS A1116
TYR A1118
HIS A1142
ARG A1192
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.4A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
None
ZN  A1301 (-2.3A)
 0.90A 5lsuB-5lsuA:
36.4		 5lsuB-5lsuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		3 / 3 ASN A1141
TYR A1179
CYH A1191
 SAM  A1304 (-2.9A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.08A 5lsuB-5lsuA:
36.4		 5lsuB-5lsuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
GLN A1072
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
None
 1.23A 5t0kA-5lsuA:
19.8		 5t0kA-5lsuA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.21A 5t0kA-5lsuA:
19.8		 5t0kA-5lsuA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.45A 5t0kA-5lsuA:
19.8		 5t0kA-5lsuA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_A_SAMA1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.02A 5t0kA-5lsuA:
19.8		 5t0kA-5lsuA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.19A 5t0kB-5lsuA:
19.9		 5t0kB-5lsuA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0K_B_SAMB1304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.29A 5t0kB-5lsuA:
19.9		 5t0kB-5lsuA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_A_SAMA1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.19A 5t0mA-5lsuA:
20.3		 5t0mA-5lsuA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.28A 5t0mB-5lsuA:
19.7		 5t0mB-5lsuA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
GLN A1072
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
None
 1.19A 5t0mB-5lsuA:
19.7		 5t0mB-5lsuA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T0M_B_SAMB1205_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.23A 5t0mB-5lsuA:
19.7		 5t0mB-5lsuA:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TEG_B_SAMB401_0
(HISTONE H4 MUTANT
PEPTIDE WITH
H4K20NORLEUCINE
N-LYSINE
METHYLTRANSFERASE
KMT5A)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 10 GLY A1074
TYR A1118
ASN A1141
HIS A1142
TYR A1179
 SAM  A1304 ( 3.2A)
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
 0.24A 5tegB-5lsuA:
13.8
5tegE-5lsuA:
undetectable		 5tegB-5lsuA:
24.15
5tegE-5lsuA:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 10 GLY A1074
TYR A1118
ASN A1141
HIS A1142
TYR A1179
 SAM  A1304 ( 3.2A)
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
 0.42A 5tqrB-5lsuA:
4.0		 5tqrB-5lsuA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 11 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.35A 5ttfA-5lsuA:
19.5		 5ttfA-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 11 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.31A 5ttfA-5lsuA:
19.5		 5ttfA-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.32A 5ttfB-5lsuA:
19.6		 5ttfB-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.50A 5ttfB-5lsuA:
19.6		 5ttfB-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.58A 5ttfC-5lsuA:
19.7		 5ttfC-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 11 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.50A 5ttfD-5lsuA:
15.8		 5ttfD-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.40A 5ttgA-5lsuA:
16.2		 5ttgA-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 1.29A 5ttgA-5lsuA:
16.2		 5ttgA-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.01A 5ttgA-5lsuA:
16.2		 5ttgA-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 11 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.42A 5ttgB-5lsuA:
8.8		 5ttgB-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 11 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.44A 5ttgB-5lsuA:
8.8		 5ttgB-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTG_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 11 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 1.27A 5ttgB-5lsuA:
8.8		 5ttgB-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.31A 5tuyA-5lsuA:
19.5		 5tuyA-5lsuA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.47A 5tuyA-5lsuA:
19.5		 5tuyA-5lsuA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
GLN A1072
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
None
 1.36A 5tuyB-5lsuA:
15.6		 5tuyB-5lsuA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.27A 5tuyB-5lsuA:
15.6		 5tuyB-5lsuA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUY_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.48A 5tuyB-5lsuA:
15.6		 5tuyB-5lsuA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
 0.47A 5tuzA-5lsuA:
16.1		 5tuzA-5lsuA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.41A 5tuzA-5lsuA:
16.1		 5tuzA-5lsuA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUZ_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.40A 5tuzB-5lsuA:
15.9		 5tuzB-5lsuA:
26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		10 / 11 ARG A1073
GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
LEU A1202
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.23A 5updA-5lsuA:
32.0		 5updA-5lsuA:
71.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		9 / 12 GLY A1074
TRP A1075
HIS A1116
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
LEU A1202
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.4A)
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
SAM  A1304 ( 4.7A)
 0.70A 5v21A-5lsuA:
25.1		 5v21A-5lsuA:
42.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.43A 5v21A-5lsuA:
25.1		 5v21A-5lsuA:
42.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5V21_A_SAMA1804_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.01A 5v21A-5lsuA:
25.1		 5v21A-5lsuA:
42.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.38A 5v9iA-5lsuA:
19.7		 5v9iA-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.46A 5v9iA-5lsuA:
19.7		 5v9iA-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 11 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.39A 5v9iB-5lsuA:
19.8		 5v9iB-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 11 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.36A 5v9iB-5lsuA:
19.8		 5v9iB-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 11 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.50A 5v9iC-5lsuA:
19.7		 5v9iC-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 11 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.03A 5v9iC-5lsuA:
19.7		 5v9iC-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9I_D_SAMD1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.56A 5v9iD-5lsuA:
19.7		 5v9iD-5lsuA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.39A 5v9jA-5lsuA:
16.1		 5v9jA-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.49A 5v9jA-5lsuA:
16.1		 5v9jA-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 1.32A 5v9jA-5lsuA:
16.1		 5v9jA-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.01A 5v9jA-5lsuA:
16.1		 5v9jA-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.43A 5v9jB-5lsuA:
19.7		 5v9jB-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 1.27A 5v9jB-5lsuA:
19.7		 5v9jB-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.03A 5v9jB-5lsuA:
19.7		 5v9jB-5lsuA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.29A 5vscA-5lsuA:
20.0		 5vscA-5lsuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
GLN A1072
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
None
 1.31A 5vscA-5lsuA:
20.0		 5vscA-5lsuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.25A 5vscA-5lsuA:
20.0		 5vscA-5lsuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.19A 5vscB-5lsuA:
15.6		 5vscB-5lsuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
GLN A1072
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
None
 1.31A 5vscB-5lsuA:
15.6		 5vscB-5lsuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSC_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.28A 5vscB-5lsuA:
15.6		 5vscB-5lsuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.45A 5vsdA-5lsuA:
16.2		 5vsdA-5lsuA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.39A 5vsdA-5lsuA:
16.2		 5vsdA-5lsuA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.41A 5vsdB-5lsuA:
16.1		 5vsdB-5lsuA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.43A 5vsdB-5lsuA:
16.1		 5vsdB-5lsuA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSD_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 1.31A 5vsdB-5lsuA:
16.1		 5vsdB-5lsuA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.31A 5vseA-5lsuA:
20.1		 5vseA-5lsuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
GLN A1072
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
None
 1.25A 5vseA-5lsuA:
20.1		 5vseA-5lsuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_A_SAMA1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.23A 5vseA-5lsuA:
20.1		 5vseA-5lsuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.20A 5vseB-5lsuA:
19.5		 5vseB-5lsuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
GLN A1072
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
None
 1.29A 5vseB-5lsuA:
19.5		 5vseB-5lsuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSE_B_SAMB1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.26A 5vseB-5lsuA:
19.5		 5vseB-5lsuA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.45A 5vsfA-5lsuA:
16.1		 5vsfA-5lsuA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_A_SAMA3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.42A 5vsfA-5lsuA:
16.1		 5vsfA-5lsuA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
 0.38A 5vsfB-5lsuA:
16.1		 5vsfB-5lsuA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VSF_B_SAMB3001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.49A 5vsfB-5lsuA:
16.1		 5vsfB-5lsuA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXD_A_SAMA501_0
(SMYD3
METHYLTRANSFERASE)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 ARG A1073
GLY A1074
ASN A1141
HIS A1142
TYR A1179
 None
SAM  A1304 ( 3.2A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
 0.85A 5xxdA-5lsuA:
5.6		 5xxdA-5lsuA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		4 / 7 THR A1150
ILE A1128
THR A1121
TYR A1179
 None
None
None
SAM  A1304 (-4.1A)
 1.03A 5zsfA-5lsuA:
undetectable
5zsfB-5lsuA:
undetectable		 5zsfA-5lsuA:
14.68
5zsfB-5lsuA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		9 / 12 ARG A1073
GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
LEU A1202
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.73A 6a5kA-5lsuA:
15.2		 6a5kA-5lsuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 ARG A1073
GLY A1076
HIS A1142
TYR A1179
CYH A1191
CYH A1193
 None
SAM  A1304 ( 4.6A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
 1.30A 6a5kA-5lsuA:
15.2		 6a5kA-5lsuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5K_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1074
TRP A1075
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.38A 6a5kA-5lsuA:
15.2		 6a5kA-5lsuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		9 / 12 ARG A1073
GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
LEU A1202
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.64A 6a5mA-5lsuA:
17.5		 6a5mA-5lsuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		9 / 12 ARG A1073
GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
 0.60A 6a5mA-5lsuA:
17.5		 6a5mA-5lsuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 ARG A1073
GLY A1076
HIS A1142
TYR A1179
CYH A1191
CYH A1193
LEU A1202
 None
SAM  A1304 ( 4.6A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 1.42A 6a5mA-5lsuA:
17.5		 6a5mA-5lsuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.46A 6a5mA-5lsuA:
17.5		 6a5mA-5lsuA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5M_A_SAMA805_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH6)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.10A 6a5mA-5lsuA:
17.5		 6a5mA-5lsuA:
20.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 11 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
 0.83A 6agoA-5lsuA:
25.3		 6agoA-5lsuA:
38.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 11 GLY A1074
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
 SAM  A1304 ( 3.2A)
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
 0.88A 6agoA-5lsuA:
25.3		 6agoA-5lsuA:
38.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6AGO_A_SAMA2301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 11 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.36A 6agoA-5lsuA:
25.3		 6agoA-5lsuA:
38.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
ARG A1138
HIS A1142
TYR A1179
CYH A1193
LEU A1202
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-4.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.77A 6bp4A-5lsuA:
19.5		 6bp4A-5lsuA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		8 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1191
CYH A1193
LEU A1202
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.61A 6bp4B-5lsuA:
20.2		 6bp4B-5lsuA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		6 / 12 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.35A 6bp4B-5lsuA:
20.2		 6bp4B-5lsuA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 0.90A 6bp4B-5lsuA:
20.2		 6bp4B-5lsuA:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.44A 6bp4B-5lsuA:
20.2		 6bp4B-5lsuA:
29.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		10 / 11 ARG A1073
GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
LEU A1202
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.46A 6cenA-5lsuA:
32.5		 6cenA-5lsuA:
77.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		5 / 12 TRP A1075
TYR A1118
PHE A1139
ASN A1141
HIS A1142
 None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.7A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
 0.39A 6chgC-5lsuA:
10.4		 6chgC-5lsuA:
26.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6INE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2
(Homo
sapiens) 		7 / 12 GLY A1074
TRP A1075
ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
 0.36A 6ineA-5lsuA:
24.6		 6ineA-5lsuA:
37.96