SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lt1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 ASP A 288
SER A 289
ASN A 293
SER A 224
 None
 1.43A 1kiaB-5lt1A:
undetectable		 1kiaB-5lt1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 6 ASP A 288
SER A 289
ASN A 293
SER A 224
 None
 1.43A 1kiaC-5lt1A:
undetectable		 1kiaC-5lt1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
ASN A 308
ASP A  27
 None
 1.31A 1p6kA-5lt1A:
undetectable		 1p6kA-5lt1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
PHE A  15
ASN A 308
 None
 1.18A 1p6kA-5lt1A:
undetectable		 1p6kA-5lt1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
ASN A 308
ASP A  27
 None
 1.26A 1p6kB-5lt1A:
undetectable		 1p6kB-5lt1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
PHE A  15
ASN A 308
 None
 1.15A 1p6kB-5lt1A:
undetectable		 1p6kB-5lt1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA999_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 VAL A  70
ILE A  69
ILE A  81
ILE A 107
ASP A 114
 None
 1.02A 1qhyA-5lt1A:
undetectable		 1qhyA-5lt1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
PHE A  15
ASN A 308
 None
 1.24A 1rs6A-5lt1A:
undetectable		 1rs6A-5lt1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
ASN A 308
ASP A  27
 None
 1.28A 1rs6B-5lt1A:
undetectable		 1rs6B-5lt1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
PHE A  15
ASN A 308
 None
 1.16A 1rs6B-5lt1A:
undetectable		 1rs6B-5lt1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
PHE A  15
ASN A 308
 None
 1.08A 1rs7B-5lt1A:
undetectable		 1rs7B-5lt1A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
PHE A  15
ASN A 308
 None
 1.20A 1zzqA-5lt1A:
undetectable		 1zzqA-5lt1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
ASN A 308
ASP A  27
 None
 1.32A 1zzqB-5lt1A:
undetectable		 1zzqB-5lt1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
PHE A  15
ASN A 308
 None
 1.16A 1zzqB-5lt1A:
undetectable		 1zzqB-5lt1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
ASN A 308
ASP A  27
 None
 1.25A 1zzuB-5lt1A:
undetectable		 1zzuB-5lt1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
PHE A  15
ASN A 308
 None
 1.13A 1zzuB-5lt1A:
undetectable		 1zzuB-5lt1A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ILE A  69
ALA A 294
LEU A 290
ILE A   9
ILE A  81
 None
 1.05A 2cd2A-5lt1A:
undetectable		 2cd2A-5lt1A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 111
ILE A 115
VAL A 212
VAL A 173
ILE A 183
 None
 1.02A 2nnhA-5lt1A:
undetectable		 2nnhA-5lt1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 SER A  54
TYR A  29
PHE A  33
VAL A  51
 None
 1.32A 2x7hA-5lt1A:
undetectable		 2x7hA-5lt1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 5 SER A  54
TYR A  29
PHE A  33
VAL A  51
 None
 1.31A 2x7hB-5lt1A:
undetectable		 2x7hB-5lt1A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 THR A 315
SER A 235
SER A  89
CYH A 301
 None
None
SO4  A 401 (-3.4A)
None
 1.27A 2xz5C-5lt1A:
undetectable
2xz5D-5lt1A:
undetectable		 2xz5C-5lt1A:
21.73
2xz5D-5lt1A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ILE A 111
THR A  94
VAL A  70
ILE A  69
ILE A  81
 None
 1.19A 2yzqA-5lt1A:
undetectable		 2yzqA-5lt1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA800_0
(GLUTAMATE RECEPTOR 2)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 7 TYR A 118
ASN A 216
LEU A 126
ASP A 123
 None
 1.06A 3lslA-5lt1A:
undetectable
3lslD-5lt1A:
undetectable		 3lslA-5lt1A:
22.26
3lslD-5lt1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 7 TYR A 118
ASN A 216
LEU A 126
ASP A 123
 None
 1.11A 3lslA-5lt1A:
undetectable
3lslD-5lt1A:
undetectable		 3lslA-5lt1A:
22.26
3lslD-5lt1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		3 / 3 SER A  89
SER A  88
HIS A  93
 SO4  A 401 (-3.4A)
SO4  A 401 (-4.6A)
None
 0.81A 3mzeA-5lt1A:
undetectable		 3mzeA-5lt1A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 8 SER A 303
ARG A  16
PHE A  15
ASN A 308
 None
 1.26A 3n62B-5lt1A:
undetectable		 3n62B-5lt1A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		4 / 6 LYS A 150
VAL A 155
LYS A 166
ILE A 285
 None
 1.24A 5q1sA-5lt1A:
undetectable		 5q1sA-5lt1A:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 5lt1 KINESIN-LIKE PROTEIN
(Homo
sapiens) 		5 / 12 ARG A 321
PHE A  82
ILE A 298
MET A 282
ILE A   9
 None
 1.42A 6gsdA-5lt1A:
undetectable		 6gsdA-5lt1A:
12.73