SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lta'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.18A 1c9sO-5ltaA:
undetectable
1c9sP-5ltaA:
undetectable
1c9sO-5ltaA:
7.00
1c9sP-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 12 LEU A 310
ILE A 383
ALA A 384
VAL A 154
ARG A 435
None
U  E   5 ( 4.2A)
None
None
BEF  A 803 ( 2.8A)
1.06A 1cbsA-5ltaA:
undetectable
1cbsA-5ltaA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.19A 1gtfC-5ltaA:
undetectable
1gtfD-5ltaA:
undetectable
1gtfC-5ltaA:
7.00
1gtfD-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.16A 1gtfE-5ltaA:
undetectable
1gtfF-5ltaA:
undetectable
1gtfE-5ltaA:
7.00
1gtfF-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.18A 1gtnN-5ltaA:
undetectable
1gtnO-5ltaA:
undetectable
1gtnN-5ltaA:
7.00
1gtnO-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_D_TRPD81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.16A 1utdD-5ltaA:
undetectable
1utdE-5ltaA:
undetectable
1utdD-5ltaA:
7.00
1utdE-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_G_TRPG81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.18A 1utdG-5ltaA:
undetectable
1utdH-5ltaA:
undetectable
1utdG-5ltaA:
7.00
1utdH-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
4 / 6 SER A 422
ALA A 424
SER A 425
THR A 458
None
0.88A 1yvpB-5ltaA:
undetectable
1yvpB-5ltaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
4 / 7 SER A 422
ALA A 424
SER A 425
THR A 458
None
0.90A 2i91A-5ltaA:
undetectable
2i91A-5ltaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
4 / 7 SER A 422
ALA A 424
SER A 425
THR A 458
None
0.91A 2i91B-5ltaA:
2.2
2i91B-5ltaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
3 / 3 ASP A 196
ASP A 228
ASP A 218
None
None
MG  A 802 ( 4.0A)
0.75A 2igtA-5ltaA:
5.5
2igtA-5ltaA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
4 / 7 VAL A 685
ALA A 666
PRO A 689
THR A 691
None
None
U  E   1 ( 4.1A)
None
1.07A 2q6oA-5ltaA:
undetectable
2q6oA-5ltaA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 VAL A 701
VAL A 665
VAL A 685
ILE A 687
VAL A 713
None
1.37A 2qboA-5ltaA:
undetectable
2qboA-5ltaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 11 LEU A 217
LEU A 230
ILE A 215
PHE A 262
LEU A 244
None
1.24A 2qeiA-5ltaA:
undetectable
2qeiA-5ltaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
4 / 6 PRO A 341
HIS A 301
ALA A 363
PRO A 366
None
1.28A 3gv1A-5ltaA:
undetectable
3gv1C-5ltaA:
undetectable
3gv1A-5ltaA:
10.36
3gv1C-5ltaA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
4 / 6 ALA A 363
PRO A 366
PRO A 341
HIS A 301
None
1.26A 3gv1A-5ltaA:
undetectable
3gv1B-5ltaA:
undetectable
3gv1A-5ltaA:
10.36
3gv1B-5ltaA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
3 / 3 PRO A 266
LEU A 267
GLN A 259
None
0.72A 3hznG-5ltaA:
undetectable
3hznH-5ltaA:
undetectable
3hznG-5ltaA:
15.32
3hznH-5ltaA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
3 / 3 ARG A 654
LEU A 585
THR A 692
None
0.88A 3oxcA-5ltaA:
undetectable
3oxcA-5ltaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
4 / 4 LYS A 100
GLN A 128
ILE A 247
LEU A 267
None
1.37A 3qt0A-5ltaA:
undetectable
3qt0A-5ltaA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
4 / 5 LEU A 313
PRO A 346
VAL A 379
ASP A 321
None
1.11A 3ufnA-5ltaA:
undetectable
3ufnB-5ltaA:
undetectable
3ufnA-5ltaA:
8.99
3ufnB-5ltaA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
4 / 8 VAL A 685
VAL A 675
GLN A 711
ARG A 410
None
1.16A 3uy4A-5ltaA:
undetectable
3uy4A-5ltaA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
4 / 8 LEU A  90
ARG A  94
TYR A 135
GLU A  67
None
1.39A 3zmdA-5ltaA:
4.1
3zmdB-5ltaA:
4.3
3zmdA-5ltaA:
13.24
3zmdB-5ltaA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 12 ARG A 432
GLY A 119
VAL A 118
GLU A 219
SER A 123
BEF  A 803 (-2.9A)
None
None
BEF  A 803 (-3.6A)
ADP  A 801 (-4.5A)
1.16A 4danA-5ltaA:
undetectable
4danB-5ltaA:
undetectable
4danA-5ltaA:
15.47
4danB-5ltaA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
4 / 6 ILE A 742
TYR A 731
TYR A 732
PHE A 737
None
1.13A 4g10A-5ltaA:
undetectable
4g10A-5ltaA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
3 / 4 SER A 158
GLY A 349
GLU A 320
None
U  E   5 ( 3.7A)
None
0.62A 4juoA-5ltaA:
3.5
4juoC-5ltaA:
2.2
4juoA-5ltaA:
22.49
4juoC-5ltaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 LEU A 518
GLY A 519
ILE A 637
LEU A 535
VAL A 533
None
1.06A 4x3mB-5ltaA:
undetectable
4x3mB-5ltaA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.18A 5eeuB-5ltaA:
undetectable
5eeuC-5ltaA:
undetectable
5eeuB-5ltaA:
7.00
5eeuC-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.16A 5eeuD-5ltaA:
undetectable
5eeuE-5ltaA:
undetectable
5eeuD-5ltaA:
7.00
5eeuE-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5eeuR-5ltaA:
undetectable
5eeuS-5ltaA:
undetectable
5eeuR-5ltaA:
7.00
5eeuS-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5eeuT-5ltaA:
undetectable
5eeuU-5ltaA:
undetectable
5eeuT-5ltaA:
7.00
5eeuU-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.18A 5eevB-5ltaA:
undetectable
5eevC-5ltaA:
undetectable
5eevB-5ltaA:
7.00
5eevC-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.16A 5eevD-5ltaA:
undetectable
5eevE-5ltaA:
undetectable
5eevD-5ltaA:
7.00
5eevE-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5eevR-5ltaA:
undetectable
5eevS-5ltaA:
undetectable
5eevR-5ltaA:
7.00
5eevS-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5eevT-5ltaA:
undetectable
5eevU-5ltaA:
undetectable
5eevT-5ltaA:
7.00
5eevU-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.18A 5eewB-5ltaA:
undetectable
5eewC-5ltaA:
undetectable
5eewB-5ltaA:
7.00
5eewC-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.16A 5eewD-5ltaA:
undetectable
5eewE-5ltaA:
undetectable
5eewD-5ltaA:
7.00
5eewE-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5eewR-5ltaA:
undetectable
5eewS-5ltaA:
undetectable
5eewR-5ltaA:
7.00
5eewS-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5eewT-5ltaA:
undetectable
5eewU-5ltaA:
undetectable
5eewT-5ltaA:
7.00
5eewU-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.18A 5eexB-5ltaA:
undetectable
5eexC-5ltaA:
undetectable
5eexB-5ltaA:
7.00
5eexC-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.16A 5eexD-5ltaA:
undetectable
5eexE-5ltaA:
undetectable
5eexD-5ltaA:
7.00
5eexE-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 11 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.17A 5eexI-5ltaA:
undetectable
5eexJ-5ltaA:
undetectable
5eexI-5ltaA:
7.00
5eexJ-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5eexR-5ltaA:
undetectable
5eexS-5ltaA:
undetectable
5eexR-5ltaA:
7.00
5eexS-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5eexT-5ltaA:
undetectable
5eexU-5ltaA:
undetectable
5eexT-5ltaA:
7.00
5eexU-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.18A 5eeyB-5ltaA:
undetectable
5eeyC-5ltaA:
undetectable
5eeyB-5ltaA:
7.00
5eeyC-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.16A 5eeyD-5ltaA:
undetectable
5eeyE-5ltaA:
undetectable
5eeyD-5ltaA:
7.00
5eeyE-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 11 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.17A 5eeyI-5ltaA:
undetectable
5eeyJ-5ltaA:
undetectable
5eeyI-5ltaA:
7.00
5eeyJ-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5eeyR-5ltaA:
undetectable
5eeyS-5ltaA:
undetectable
5eeyR-5ltaA:
7.00
5eeyS-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.20A 5eeyT-5ltaA:
undetectable
5eeyU-5ltaA:
undetectable
5eeyT-5ltaA:
7.00
5eeyU-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.18A 5eezB-5ltaA:
undetectable
5eezC-5ltaA:
undetectable
5eezB-5ltaA:
7.00
5eezC-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.16A 5eezD-5ltaA:
undetectable
5eezE-5ltaA:
undetectable
5eezD-5ltaA:
7.00
5eezE-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 11 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.17A 5eezI-5ltaA:
undetectable
5eezJ-5ltaA:
undetectable
5eezI-5ltaA:
7.00
5eezJ-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5eezR-5ltaA:
undetectable
5eezS-5ltaA:
undetectable
5eezR-5ltaA:
7.00
5eezS-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.20A 5eezT-5ltaA:
undetectable
5eezU-5ltaA:
undetectable
5eezT-5ltaA:
7.00
5eezU-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.18A 5ef0B-5ltaA:
undetectable
5ef0C-5ltaA:
undetectable
5ef0B-5ltaA:
7.00
5ef0C-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.16A 5ef0D-5ltaA:
undetectable
5ef0E-5ltaA:
undetectable
5ef0D-5ltaA:
7.00
5ef0E-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 11 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.17A 5ef0I-5ltaA:
undetectable
5ef0J-5ltaA:
undetectable
5ef0I-5ltaA:
7.00
5ef0J-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5ef0R-5ltaA:
undetectable
5ef0S-5ltaA:
undetectable
5ef0R-5ltaA:
7.00
5ef0S-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.20A 5ef0T-5ltaA:
undetectable
5ef0U-5ltaA:
undetectable
5ef0T-5ltaA:
7.00
5ef0U-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.18A 5ef1B-5ltaA:
undetectable
5ef1C-5ltaA:
undetectable
5ef1B-5ltaA:
7.00
5ef1C-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.16A 5ef1D-5ltaA:
undetectable
5ef1E-5ltaA:
undetectable
5ef1D-5ltaA:
7.00
5ef1E-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 11 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.17A 5ef1I-5ltaA:
undetectable
5ef1J-5ltaA:
undetectable
5ef1I-5ltaA:
7.00
5ef1J-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5ef1R-5ltaA:
undetectable
5ef1S-5ltaA:
undetectable
5ef1R-5ltaA:
7.00
5ef1S-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.20A 5ef1T-5ltaA:
undetectable
5ef1U-5ltaA:
undetectable
5ef1T-5ltaA:
7.00
5ef1U-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.18A 5ef2B-5ltaA:
undetectable
5ef2C-5ltaA:
undetectable
5ef2B-5ltaA:
7.00
5ef2C-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.16A 5ef2D-5ltaA:
undetectable
5ef2E-5ltaA:
undetectable
5ef2D-5ltaA:
7.00
5ef2E-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 11 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.17A 5ef2I-5ltaA:
undetectable
5ef2J-5ltaA:
undetectable
5ef2I-5ltaA:
7.00
5ef2J-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5ef2R-5ltaA:
undetectable
5ef2S-5ltaA:
undetectable
5ef2R-5ltaA:
7.00
5ef2S-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.20A 5ef2T-5ltaA:
undetectable
5ef2U-5ltaA:
undetectable
5ef2T-5ltaA:
7.00
5ef2U-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_B_TRPB101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 9 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.17A 5ef3B-5ltaA:
undetectable
5ef3C-5ltaA:
undetectable
5ef3B-5ltaA:
7.00
5ef3C-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.16A 5ef3D-5ltaA:
undetectable
5ef3E-5ltaA:
undetectable
5ef3D-5ltaA:
7.00
5ef3E-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 11 THR A 717
HIS A 584
ALA A 656
HIS A 579
ILE A 547
None
1.17A 5ef3I-5ltaA:
undetectable
5ef3J-5ltaA:
undetectable
5ef3I-5ltaA:
7.00
5ef3J-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_S_TRPS101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.19A 5ef3R-5ltaA:
undetectable
5ef3S-5ltaA:
undetectable
5ef3R-5ltaA:
7.00
5ef3S-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_U_TRPU101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 HIS A 584
ALA A 656
HIS A 579
ILE A 547
THR A 717
None
1.20A 5ef3T-5ltaA:
undetectable
5ef3U-5ltaA:
undetectable
5ef3T-5ltaA:
7.00
5ef3U-5ltaA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
3 / 3 ASP A 622
SER A 549
TYR A 591
None
0.91A 5glmA-5ltaA:
undetectable
5glmA-5ltaA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
3 / 3 HIS A 611
GLU A 610
TRP A 607
None
0.87A 5odiD-5ltaA:
2.2
5odiD-5ltaA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
3 / 3 HIS A 611
GLU A 610
TRP A 607
None
0.82A 5odqD-5ltaA:
2.3
5odqD-5ltaA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
3 / 3 HIS A 611
GLU A 610
TRP A 607
None
0.83A 5odrD-5ltaA:
undetectable
5odrD-5ltaA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 10 PHE A 737
GLY A 740
ALA A 745
LEU A 746
PHE A 541
None
1.48A 5zjiA-5ltaA:
undetectable
5zjiJ-5ltaA:
undetectable
5zjiA-5ltaA:
7.14
5zjiJ-5ltaA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
4 / 6 GLU A 385
HIS A 221
ALA A 424
GLN A 427
None
1.27A 6f6jC-5ltaA:
undetectable
6f6jD-5ltaA:
undetectable
6f6jC-5ltaA:
19.69
6f6jD-5ltaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Chaetomium
thermophilum)
5 / 12 LEU A  90
THR A  78
GLY A  79
ASP A  71
ASN A  99
None
1.17A 6gngA-5ltaA:
undetectable
6gngA-5ltaA:
22.95