SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ltg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		4 / 8 ALA A 447
PHE A 501
THR A 453
THR A 451
 None
 0.82A 3bpxA-5ltgA:
undetectable
3bpxB-5ltgA:
undetectable		 3bpxA-5ltgA:
14.53
3bpxB-5ltgA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		3 / 3 ALA A 240
ARG A 248
LYS A 257
 None
FLC  A 602 (-3.2A)
None
 1.04A 3kp3B-5ltgA:
undetectable		 3kp3B-5ltgA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		5 / 11 ALA A 284
ILE A 247
SER A 272
LEU A 273
ALA A 240
 None
 1.27A 3kw2A-5ltgA:
undetectable		 3kw2A-5ltgA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		3 / 3 ARG A 130
GLU A 129
ASN A 172
 None
 0.91A 4imaD-5ltgA:
undetectable		 4imaD-5ltgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		3 / 3 ARG A 130
GLU A 129
ASN A 172
 None
 0.88A 4ip7D-5ltgA:
undetectable		 4ip7D-5ltgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		5 / 12 ILE A 205
LEU A 230
LEU A 237
ILE A 206
THR A 155
 None
 1.06A 4m2xC-5ltgA:
undetectable		 4m2xC-5ltgA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		4 / 6 LEU A 115
LEU A 101
GLU A 114
ILE A 103
 None
 0.93A 4ww7A-5ltgA:
undetectable		 4ww7A-5ltgA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		5 / 12 THR A 254
ALA A 253
LEU A 235
LEU A 230
LEU A 258
 None
 1.30A 4xi3D-5ltgA:
undetectable		 4xi3D-5ltgA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		5 / 11 LEU A 174
TYR A 176
GLY A 161
ILE A 139
VAL A 133
 None
 1.22A 5hjiA-5ltgA:
undetectable		 5hjiA-5ltgA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		5 / 12 ALA A 274
PHE A  39
PHE A  43
GLN A 521
VAL A  46
 None
 1.25A 5tudD-5ltgA:
undetectable		 5tudD-5ltgA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		4 / 8 ILE A 206
ALA A 253
LEU A 236
ILE A 218
 None
 0.80A 5uihA-5ltgA:
undetectable		 5uihA-5ltgA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		4 / 6 PHE A 524
GLY A 500
GLN A 520
TYR A 503
 None
 1.19A 6ag0C-5ltgA:
undetectable		 6ag0C-5ltgA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		5 / 12 ILE A 270
THR A 239
ILE A 247
HIS A 221
PRO A 179
 None
None
None
FLC  A 602 (-3.8A)
None
 1.07A 6hlpA-5ltgA:
undetectable		 6hlpA-5ltgA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		4 / 4 ASP A 463
ILE A 466
PRO A 467
LEU A 465
 None
 1.48A 6mkeB-5ltgA:
undetectable		 6mkeB-5ltgA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5ltg AUTOPHAGY-RELATED
PROTEIN 18
(Ogataea
angusta) 		4 / 4 ASP A 463
ILE A 466
PRO A 467
LEU A 465
 None
 1.39A 6mkeA-5ltgA:
undetectable		 6mkeA-5ltgA:
10.12