SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lti'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE
(Pseudomonas
mendocina) 		5 / 11 VAL A 197
ALA A 178
GLU A 266
ILE A 283
ASP A 156
 HEM  A 501 (-4.2A)
DMN  A 502 ( 4.4A)
DMN  A 502 (-2.9A)
DMN  A 502 ( 4.7A)
None
 1.30A 2admB-5ltiA:
undetectable		 2admB-5ltiA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_A_NCAA1501_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE
(Pseudomonas
mendocina) 		4 / 7 PHE A 135
ARG A 115
ASP A 118
ARG A 275
 None
 1.17A 2e5dA-5ltiA:
undetectable
2e5dB-5ltiA:
undetectable		 2e5dA-5ltiA:
21.51
2e5dB-5ltiA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E5D_B_NCAB1502_0
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE
(Pseudomonas
mendocina) 		4 / 7 PHE A 135
ARG A 115
ASP A 118
ARG A 275
 None
 1.19A 2e5dA-5ltiA:
undetectable
2e5dB-5ltiA:
undetectable		 2e5dA-5ltiA:
21.51
2e5dB-5ltiA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE
(Pseudomonas
mendocina) 		5 / 11 LEU A 182
LEU A  83
ARG A 183
LEU A  75
ASP A  78
 None
 1.20A 2q6hA-5ltiA:
undetectable		 2q6hA-5ltiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE
(Pseudomonas
mendocina) 		5 / 11 LEU A 182
LEU A  83
ARG A 183
LEU A  75
ASP A  78
 None
 1.21A 2q72A-5ltiA:
undetectable		 2q72A-5ltiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)		 5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE
(Pseudomonas
mendocina) 		5 / 11 LEU A 182
LEU A  83
ARG A 183
LEU A  75
ASP A  78
 None
 1.21A 2qeiA-5ltiA:
undetectable		 2qeiA-5ltiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE
(Pseudomonas
mendocina) 		5 / 11 ALA A 178
GLY A 319
ILE A 320
PRO A 198
VAL A 197
 DMN  A 502 ( 4.4A)
None
None
None
HEM  A 501 (-4.2A)
 1.04A 3el1A-5ltiA:
undetectable		 3el1A-5ltiA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE
(Pseudomonas
mendocina) 		5 / 12 GLU A 101
PHE A  58
ARG A 105
ALA A  45
GLY A 219
 None
 1.35A 3jzjA-5ltiA:
undetectable		 3jzjA-5ltiA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE
(Pseudomonas
mendocina) 		3 / 3 HIS A 194
LYS A 191
PHE A 190
 HEM  A 501 (-3.2A)
None
HEM  A 501 (-4.8A)
 0.98A 5klaA-5ltiA:
undetectable		 5klaA-5ltiA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE
(Pseudomonas
mendocina) 		3 / 3 ARG A  71
ARG A  81
ARG A  73
 None
 0.93A 5vcgA-5ltiA:
undetectable		 5vcgA-5ltiA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE
(Pseudomonas
mendocina) 		4 / 7 GLU A 240
TRP A 245
ARG A 234
PRO A 177
 None
 1.36A 6a4iB-5ltiA:
undetectable		 6a4iB-5ltiA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5lti HEME DEPENDENT
OXIDATIVE
N-DEMETHYLASE
(Pseudomonas
mendocina) 		4 / 5 ARG A 115
LEU A 113
GLN A 123
PHE A 135
 None
 1.50A 6nmpP-5ltiA:
undetectable
6nmpW-5ltiA:
undetectable		 6nmpP-5ltiA:
18.62
6nmpW-5ltiA:
11.28