SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lts'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 5lts RNA-DIRECTED RNA
POLYMERASE L
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 9 LEU A  82
LEU A 129
VAL A 134
SER A  67
ILE A  71
 None
 1.14A 3freX-5ltsA:
undetectable		 3freX-5ltsA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5lts RNA-DIRECTED RNA
POLYMERASE L
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 11 LEU A  45
LEU A  42
LEU A   7
MET A 151
LEU A  21
 None
 1.34A 3hm1B-5ltsA:
undetectable		 3hm1B-5ltsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 5lts RNA-DIRECTED RNA
POLYMERASE L
(Lymphocytic
choriomeningitis
mammarenavirus) 		4 / 5 VAL A  68
LEU A  82
ILE A 125
VAL A 134
 None
 0.82A 4a9kB-5ltsA:
undetectable		 4a9kB-5ltsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 5lts RNA-DIRECTED RNA
POLYMERASE L
(Lymphocytic
choriomeningitis
mammarenavirus) 		4 / 7 LEU A  21
ASP A  18
HIS A  63
HIS A  61
 None
 1.09A 4aq7A-5ltsA:
undetectable		 4aq7A-5ltsA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5lts RNA-DIRECTED RNA
POLYMERASE L
(Lymphocytic
choriomeningitis
mammarenavirus) 		4 / 7 LEU A  21
ASP A  18
HIS A  63
HIS A  61
 None
 0.89A 4arcA-5ltsA:
undetectable		 4arcA-5ltsA:
15.16