SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lu2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 8 ARG A 117
ASN A 166
SER A 158
VAL A 118
 None
 1.22A 1u1jA-5lu2A:
undetectable		 1u1jA-5lu2A:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2O02_A_BEZA801_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.10A 2o02A-5lu2A:
33.7		 2o02A-5lu2A:
73.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_C_RBVC601_1
(RNA POLYMERASE)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		5 / 11 ARG A  56
LEU A  92
LEU A 100
GLY A 125
ASP A 126
 None
 1.43A 3sfuC-5lu2A:
undetectable		 3sfuC-5lu2A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 8 GLU A  86
GLU A  83
TYR A  84
ARG A  85
 None
 0.86A 4fgzA-5lu2A:
undetectable
4fgzB-5lu2A:
undetectable		 4fgzA-5lu2A:
23.10
4fgzB-5lu2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		5 / 9 SER A 158
ALA A 154
ALA A 150
GLY A 171
ASP A 126
 None
 1.05A 5d0xK-5lu2A:
undetectable
5d0xL-5lu2A:
undetectable		 5d0xK-5lu2A:
20.49
5d0xL-5lu2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		5 / 9 SER A 158
ALA A 154
ALA A 150
GLY A 171
ASP A 126
 None
 1.03A 5d0xY-5lu2A:
undetectable
5d0xZ-5lu2A:
undetectable		 5d0xY-5lu2A:
20.49
5d0xZ-5lu2A:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EWZ_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.06A 5ewzA-5lu2A:
31.7		 5ewzA-5lu2A:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EXA_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.09A 5exaA-5lu2A:
33.9		 5exaA-5lu2A:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EXA_B_BEZB303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.05A 5exaB-5lu2A:
33.9		 5exaB-5lu2A:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 5 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 0.97A 5jm4A-5lu2A:
32.9		 5jm4A-5lu2A:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M35_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 5 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.06A 5m35A-5lu2A:
33.4		 5m35A-5lu2A:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M35_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 5 PHE A 198
THR A 217
MET A 220
ARG A 224
 None
 0.85A 5m35A-5lu2A:
33.4		 5m35A-5lu2A:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M36_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.11A 5m36B-5lu2A:
33.2		 5m36B-5lu2A:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M37_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.09A 5m37B-5lu2A:
33.8		 5m37B-5lu2A:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNA_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.11A 6fnaA-5lu2A:
34.0		 6fnaA-5lu2A:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNB_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.13A 6fnbB-5lu2A:
33.6		 6fnbB-5lu2A:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNC_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.11A 6fncA-5lu2A:
33.6		 6fncA-5lu2A:
73.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6FNC_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5lu2 14-3-3 PROTEIN SIGMA
(Homo
sapiens) 		4 / 4 PHE A 198
MET A 220
GLN A 221
ARG A 224
 None
 1.09A 6fncB-5lu2A:
33.7		 6fncB-5lu2A:
73.16