SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lu4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		3 / 3 ALA A 458
VAL A 460
TRP A 464
 None
 0.90A 1micA-5lu4A:
undetectable
1micB-5lu4A:
undetectable		 1micA-5lu4A:
2.66
1micB-5lu4A:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		3 / 3 ASP A 133
ARG A 137
ASP A 170
 None
 0.92A 1vptA-5lu4A:
undetectable		 1vptA-5lu4A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		4 / 6 LEU A  90
SER A 134
PHE A 130
ASP A 133
 None
 1.33A 2vn1B-5lu4A:
undetectable		 2vn1B-5lu4A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 11 VAL A 256
LEU A 257
GLY A 271
SER A 263
LYS A 345
 None
 1.14A 3bjwB-5lu4A:
undetectable		 3bjwB-5lu4A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 11 VAL A 256
LEU A 257
GLY A 271
SER A 263
LYS A 345
 None
 1.09A 3bjwE-5lu4A:
undetectable		 3bjwE-5lu4A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 12 VAL A 256
LEU A 257
GLY A 271
SER A 263
LYS A 345
 None
 1.14A 3bjwF-5lu4A:
undetectable		 3bjwF-5lu4A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 11 VAL A 256
LEU A 257
GLY A 271
SER A 263
LYS A 345
 None
 1.00A 3bjwH-5lu4A:
undetectable		 3bjwH-5lu4A:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		3 / 3 ASN A 115
MET A 243
PHE A 138
 None
ADP  A 901 (-3.5A)
None
 0.76A 3g4lD-5lu4A:
undetectable		 3g4lD-5lu4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		3 / 3 ASN A 826
MET A 707
PHE A 766
 None
 1.14A 3g4lD-5lu4A:
undetectable		 3g4lD-5lu4A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		4 / 5 ILE A 149
PHE A 154
ASP A 155
GLU A 156
 None
 1.01A 3kp6A-5lu4A:
undetectable
3kp6B-5lu4A:
undetectable		 3kp6A-5lu4A:
11.70
3kp6B-5lu4A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		4 / 7 GLU A 716
HIS A 719
GLN A 720
VAL A 708
 None
 1.04A 3kp6B-5lu4A:
undetectable		 3kp6B-5lu4A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 10 GLY A 113
LEU A  72
LEU A 112
ASN A 111
ILE A 240
 None
 1.13A 3wdmB-5lu4A:
undetectable		 3wdmB-5lu4A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 9 GLY A 113
LEU A  72
LEU A 112
ASN A 111
ILE A 240
 None
 1.13A 3wdmC-5lu4A:
undetectable		 3wdmC-5lu4A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		3 / 3 PHE A 766
ASP A 853
ARG A 823
 None
 0.90A 4eahF-5lu4A:
1.0		 4eahF-5lu4A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		3 / 3 PHE A 766
ASP A 853
ARG A 823
 None
 0.88A 4eahG-5lu4A:
1.1		 4eahG-5lu4A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 12 LEU A 122
VAL A 118
PHE A 197
VAL A 109
VAL A 182
 None
 1.28A 4ib4A-5lu4A:
undetectable		 4ib4A-5lu4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		4 / 8 ILE A 475
ILE A 491
VAL A 428
VAL A 469
 None
 0.81A 4jltA-5lu4A:
undetectable		 4jltA-5lu4A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 9 ALA A 208
GLN A  76
LEU A  90
LEU A 205
LEU A  92
 None
 1.43A 4x30A-5lu4A:
undetectable		 4x30A-5lu4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		4 / 4 VAL A 212
ALA A 237
ILE A 240
THR A  44
 None
 1.12A 5e4dB-5lu4A:
undetectable		 5e4dB-5lu4A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 12 LEU A 269
LEU A 292
ILE A 275
TYR A 303
ALA A 302
 None
 1.06A 5ienB-5lu4A:
undetectable		 5ienB-5lu4A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		3 / 3 GLY A 779
THR A 713
PRO A 750
 None
 0.59A 5v5zA-5lu4A:
undetectable		 5v5zA-5lu4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 12 GLY A 557
ALA A 555
SER A 767
GLU A 748
ASN A 771
 None
None
None
MG  A 904 ( 2.7A)
PYR  A 903 (-3.8A)
 1.05A 6bqgA-5lu4A:
undetectable		 6bqgA-5lu4A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 12 THR A 236
VAL A 238
VAL A  94
ASP A 217
ASN A 210
 None
 1.31A 6iblA-5lu4A:
undetectable		 6iblA-5lu4A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_E_FFOE403_0
(THYMIDYLATE SYNTHASE)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 12 ILE A 815
TYR A 854
LEU A 773
GLY A 769
ALA A 752
 None
None
None
PYR  A 903 (-3.2A)
None
 0.99A 6r2eE-5lu4A:
undetectable		 6r2eE-5lu4A:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC
(Flaveria
trinervia) 		5 / 12 ILE A 815
TYR A 854
LEU A 773
GLY A 769
ALA A 752
 None
None
None
PYR  A 903 (-3.2A)
None
 1.05A 6r2eH-5lu4A:
undetectable		 6r2eH-5lu4A:
16.70