SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lub'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 5lub LEGUMAIN
(Homo
sapiens) 		3 / 3 VAL B 141
VAL B  32
TRP B  30
 None
 0.59A 1av2A-5lubB:
undetectable
1av2B-5lubB:
undetectable		 1av2A-5lubB:
4.33
1av2B-5lubB:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5lub LEGUMAIN
(Homo
sapiens) 		5 / 10 ILE B  87
ASP B  48
GLY B 230
TYR B 144
ALA B  52
 None
 1.45A 1ju6C-5lubB:
undetectable		 1ju6C-5lubB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5lub LEGUMAIN
(Homo
sapiens) 		5 / 11 ILE B  87
ASP B  48
GLY B 230
TYR B 144
ALA B  52
 None
 1.45A 1ju6D-5lubB:
undetectable		 1ju6D-5lubB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 5lub LEGUMAIN
(Homo
sapiens) 		3 / 3 VAL B  32
TRP B  30
VAL B 141
 None
 0.69A 2izqC-5lubB:
undetectable
2izqD-5lubB:
undetectable		 2izqC-5lubB:
4.33
2izqD-5lubB:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5lub LEGUMAIN
(Homo
sapiens) 		4 / 8 ASP B  48
HIS B  45
ASP B 231
GLY B 230
 None
SNN  B 147 (-3.3A)
3Y7  B 304 (-3.7A)
None
 0.92A 3c0zB-5lubB:
undetectable		 3c0zB-5lubB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 5lub LEGUMAIN
(Homo
sapiens) 		3 / 3 LYS B 101
ASN B 112
ASP B  72
 None
 0.83A 4o1eA-5lubB:
undetectable		 4o1eA-5lubB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5lub LEGUMAIN
(Homo
sapiens) 		4 / 5 LEU B 161
LEU B 154
MET B  69
GLN B 111
 None
 1.20A 5uc3A-5lubB:
undetectable		 5uc3A-5lubB:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 5lub LEGUMAIN
(Homo
sapiens) 		4 / 7 LEU B 117
ILE B 170
THR B 169
PHE B 184
 None
 0.96A 5zsfA-5lubB:
undetectable
5zsfB-5lubB:
undetectable		 5zsfA-5lubB:
14.40
5zsfB-5lubB:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)		 5lub LEGUMAIN
(Homo
sapiens) 		5 / 12 VAL B  32
ILE B  33
ILE B  55
TYR B 205
ILE B 275
 None
 1.27A 6mkeA-5lubB:
undetectable
6mkeD-5lubB:
undetectable		 6mkeA-5lubB:
13.69
6mkeD-5lubB:
13.69