SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lun'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		4 / 5 THR A  97
GLU A  84
THR A  86
HIS A 189
 None
ARG  A 403 (-3.5A)
ARG  A 403 (-3.4A)
FE  A 401 (-3.3A)
 1.44A 1d4fA-5lunA:
undetectable		 1d4fA-5lunA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 12 VAL A 119
PRO A 122
SER A  55
PHE A  58
MET A 134
 None
 1.15A 1fdsA-5lunA:
undetectable		 1fdsA-5lunA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		4 / 6 ARG A 108
GLY A 166
ASP A 165
TRP A 167
 None
 1.30A 1kf6M-5lunA:
undetectable
1kf6N-5lunA:
undetectable		 1kf6M-5lunA:
21.76
1kf6N-5lunA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		4 / 7 ARG A 277
ALA A 279
ILE A 186
ILE A  95
 OGA  A 402 (-2.7A)
OGA  A 402 (-3.6A)
ARG  A 403 (-4.7A)
None
 0.79A 1oniD-5lunA:
undetectable
1oniF-5lunA:
undetectable		 1oniD-5lunA:
17.01
1oniF-5lunA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 12 HIS A 189
ASP A 191
LEU A 206
HIS A 268
PHE A 283
 FE  A 401 (-3.3A)
FE  A 401 (-2.4A)
OGA  A 402 (-3.5A)
FE  A 401 ( 3.2A)
ARG  A 403 ( 4.2A)
 0.50A 1uobA-5lunA:
21.1		 1uobA-5lunA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		4 / 8 PHE A  58
ARG A 321
ALA A  80
LEU A  63
 None
 1.10A 1x8vA-5lunA:
0.9		 1x8vA-5lunA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		3 / 3 MET A 313
ASN A 218
GLN A 256
 ARG  A 403 ( 4.6A)
None
None
 0.97A 1xoqB-5lunA:
undetectable		 1xoqB-5lunA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 12 ILE A 186
THR A 190
ASN A 220
HIS A 189
SER A 226
 ARG  A 403 (-4.7A)
None
None
FE  A 401 (-3.3A)
None
 1.43A 2gl0A-5lunA:
undetectable
2gl0C-5lunA:
undetectable		 2gl0A-5lunA:
20.40
2gl0C-5lunA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 12 HIS A 189
SER A 226
ILE A 186
THR A 190
ASN A 220
 FE  A 401 (-3.3A)
None
ARG  A 403 (-4.7A)
None
None
 1.40A 2gl0D-5lunA:
undetectable
2gl0E-5lunA:
undetectable		 2gl0D-5lunA:
20.40
2gl0E-5lunA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 12 HIS A 189
PHE A 250
ILE A 186
SER A 265
ASP A 191
 FE  A 401 (-3.3A)
None
ARG  A 403 (-4.7A)
None
FE  A 401 (-2.4A)
 1.41A 2pgfA-5lunA:
undetectable		 2pgfA-5lunA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		3 / 3 GLU A 142
HIS A 284
THR A 163
 None
 0.79A 3hkuA-5lunA:
undetectable		 3hkuA-5lunA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		4 / 8 ASN A 220
HIS A 309
ASN A 312
MET A 313
 None
None
None
ARG  A 403 ( 4.6A)
 1.29A 3kp6A-5lunA:
undetectable
3kp6B-5lunA:
0.5		 3kp6A-5lunA:
17.13
3kp6B-5lunA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		4 / 7 GLU A  84
TYR A 192
PHE A 314
TYR A 318
 ARG  A 403 (-3.5A)
ARG  A 403 (-4.0A)
ARG  A 403 (-3.9A)
None
 1.20A 3ku9B-5lunA:
undetectable		 3ku9B-5lunA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 11 GLU A 142
HIS A 284
ALA A 292
LEU A 162
THR A 163
 None
 1.21A 3mdzA-5lunA:
undetectable		 3mdzA-5lunA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 11 THR A 148
ALA A 149
VAL A  13
ALA A 140
GLY A 141
 None
 0.97A 3mg0K-5lunA:
undetectable
3mg0L-5lunA:
undetectable		 3mg0K-5lunA:
18.36
3mg0L-5lunA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		4 / 8 ASP A  45
GLN A 200
PRO A 242
PRO A 244
 None
 1.06A 3oyaA-5lunA:
undetectable		 3oyaA-5lunA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 12 GLY A 187
GLY A 185
LEU A 272
LYS A  89
ALA A  87
 None
 1.10A 3vywB-5lunA:
undetectable		 3vywB-5lunA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		4 / 7 ASP A 191
ARG A 316
HIS A 309
HIS A 268
 FE  A 401 (-2.4A)
ARG  A 403 (-3.7A)
None
FE  A 401 ( 3.2A)
 1.06A 3zodA-5lunA:
undetectable		 3zodA-5lunA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 12 PHE A 250
GLN A 200
ALA A 279
ALA A 198
ALA A 281
 None
None
OGA  A 402 (-3.6A)
OGA  A 402 ( 4.2A)
OGA  A 402 ( 3.7A)
 1.08A 4j6dA-5lunA:
undetectable		 4j6dA-5lunA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 12 PHE A 250
GLN A 200
ALA A 279
ALA A 198
ALA A 281
 None
None
OGA  A 402 (-3.6A)
OGA  A 402 ( 4.2A)
OGA  A 402 ( 3.7A)
 1.08A 4j6dB-5lunA:
undetectable		 4j6dB-5lunA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 12 PHE A 250
GLN A 200
ALA A 279
ALA A 198
ALA A 281
 None
None
OGA  A 402 (-3.6A)
OGA  A 402 ( 4.2A)
OGA  A 402 ( 3.7A)
 1.10A 4jbtA-5lunA:
undetectable		 4jbtA-5lunA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 12 PHE A 283
ARG A 321
GLY A  77
TYR A 126
LEU A 173
 ARG  A 403 ( 4.2A)
None
None
None
OGA  A 402 (-4.5A)
 1.50A 4kotA-5lunA:
undetectable		 4kotA-5lunA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 12 PHE A 283
ARG A 321
GLY A  77
TYR A 126
LEU A 173
 ARG  A 403 ( 4.2A)
None
None
None
OGA  A 402 (-4.5A)
 1.50A 4kowA-5lunA:
undetectable		 4kowA-5lunA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		4 / 5 THR A 190
GLU A 285
HIS A 169
ASP A 253
 None
 1.17A 5c0oH-5lunA:
undetectable		 5c0oH-5lunA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		4 / 4 GLN A   5
THR A   6
LEU A 147
LEU A  26
 None
 1.14A 5m5kB-5lunA:
undetectable		 5m5kB-5lunA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		4 / 7 VAL A  79
ARG A 174
GLU A  94
LEU A 272
 None
 1.20A 5umwB-5lunA:
undetectable
5umwE-5lunA:
undetectable		 5umwB-5lunA:
12.50
5umwE-5lunA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 12 LEU A 195
GLY A 166
LEU A 137
GLY A 138
GLY A 141
 None
 0.89A 5wyqA-5lunA:
undetectable		 5wyqA-5lunA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME
(Pseudomonas
savastanoi) 		5 / 11 ALA A 281
TYR A 318
ASP A  91
GLU A  84
THR A  97
 OGA  A 402 ( 3.7A)
None
ARG  A 403 ( 4.7A)
ARG  A 403 (-3.5A)
None
 1.22A 6dk1C-5lunA:
4.3		 6dk1C-5lunA:
21.55