SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lv9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 TRP A 284
ALA A 301
VAL A 299
 None
 0.94A 1av2C-5lv9A:
undetectable
1av2D-5lv9A:
undetectable		 1av2C-5lv9A:
4.63
1av2D-5lv9A:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 4 GLY A 234
LEU A 235
GLY A 231
ARG A 233
 None
 0.98A 1j7kA-5lv9A:
undetectable		 1j7kA-5lv9A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		5 / 12 ILE A 348
LEU A  21
GLY A 349
THR A  17
LEU A 373
 None
 1.04A 1liiA-5lv9A:
3.6		 1liiA-5lv9A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 7 ILE A 288
GLY A  45
PHE A 174
ASN A  71
 None
 0.91A 1oniG-5lv9A:
undetectable
1oniI-5lv9A:
undetectable		 1oniG-5lv9A:
12.97
1oniI-5lv9A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		5 / 12 LEU A 236
LEU A 235
GLY A 234
GLN A 239
ILE A 227
 None
 1.31A 1p93A-5lv9A:
undetectable		 1p93A-5lv9A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 6 TYR A 390
SER A 352
ALA A 347
SER A 340
 None
 1.02A 1yvpB-5lv9A:
2.8		 1yvpB-5lv9A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		5 / 11 ARG A  53
ILE A  52
ILE A 363
GLY A  60
LEU A 183
 None
 1.06A 2azyA-5lv9A:
undetectable		 2azyA-5lv9A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 7 GLY A 223
THR A 222
ASP A 224
ASN A   4
 None
 0.95A 2g70A-5lv9A:
1.8		 2g70A-5lv9A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 7 GLY A 223
THR A 222
ASP A 224
ASN A   4
 None
 0.89A 2g70B-5lv9A:
1.8		 2g70B-5lv9A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 7 TYR A 390
SER A 352
ALA A 347
SER A 340
 None
 1.04A 2i91A-5lv9A:
undetectable		 2i91A-5lv9A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 7 TYR A 390
SER A 352
ALA A 347
SER A 340
 None
 1.04A 2i91B-5lv9A:
undetectable		 2i91B-5lv9A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		5 / 12 ALA A  13
ALA A 180
GLY A 362
GLY A 349
TYR A 172
 None
 1.07A 2igtA-5lv9A:
3.6		 2igtA-5lv9A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		5 / 12 ALA A  13
ALA A 180
GLY A 362
GLY A 349
TYR A 172
 None
 1.08A 2igtB-5lv9A:
3.7		 2igtB-5lv9A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 ALA A 301
VAL A 299
TRP A 284
 None
 0.92A 2izqA-5lv9A:
undetectable
2izqB-5lv9A:
undetectable		 2izqA-5lv9A:
4.63
2izqB-5lv9A:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		5 / 10 SER A 352
ILE A 348
ILE A 227
LEU A 373
ASN A 376
 None
 1.25A 2nnhB-5lv9A:
undetectable		 2nnhB-5lv9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 8 TYR A 170
SER A 460
LEU A 272
THR A 106
 None
 1.16A 2v0zO-5lv9A:
undetectable		 2v0zO-5lv9A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 8 SER A 460
PHE A 404
TYR A 459
PHE A  49
 None
 1.10A 2wekA-5lv9A:
undetectable		 2wekA-5lv9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 8 SER A 460
PHE A 404
TYR A 459
PHE A  49
 None
 1.08A 2wekB-5lv9A:
undetectable		 2wekB-5lv9A:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2WET_B_TRPB650_0
(TRYPTOPHAN
5-HALOGENASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		6 / 10 PHE A  49
SER A  50
HIS A  92
PHE A  94
GLN A 167
TYR A 459
 None
 0.75A 2wetB-5lv9A:
53.8		 2wetB-5lv9A:
54.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 6 LEU A  21
THR A  17
LEU A  33
ASP A  30
 None
 1.00A 2wm3A-5lv9A:
6.9		 2wm3A-5lv9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 GLU A 161
HIS A 368
HIS A 367
 None
 0.78A 3co4A-5lv9A:
undetectable		 3co4A-5lv9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 CYH A 274
PRO A  93
ASP A 130
 None
 0.87A 3hlwB-5lv9A:
undetectable		 3hlwB-5lv9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 8 TYR A 453
GLU A 161
PHE A 364
ILE A 366
 None
 1.07A 3jz0B-5lv9A:
undetectable		 3jz0B-5lv9A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 5 MET A 462
PHE A  90
PHE A 118
PHE A 123
 None
 1.43A 3ko0F-5lv9A:
0.2
3ko0G-5lv9A:
0.0		 3ko0F-5lv9A:
11.99
3ko0G-5lv9A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LK0_D_Z80D92_1
(PROTEIN S100-B)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 HIS A 396
PHE A 365
PHE A 364
 None
 0.77A 3lk0D-5lv9A:
undetectable		 3lk0D-5lv9A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 7 GLU A  81
LEU A 272
ARG A 269
THR A 287
 None
 1.15A 3mbgA-5lv9A:
undetectable
3mbgB-5lv9A:
undetectable		 3mbgA-5lv9A:
13.23
3mbgB-5lv9A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 ARG A 426
THR A 417
TRP A 420
 None
 0.98A 4d7hA-5lv9A:
undetectable		 4d7hA-5lv9A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_D_VK3D202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 5 TRP A  66
ARG A 136
TYR A 172
TYR A 170
 None
 1.36A 4f8yC-5lv9A:
2.3
4f8yD-5lv9A:
2.2		 4f8yC-5lv9A:
17.03
4f8yD-5lv9A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 TYR A 300
GLN A 249
TRP A 284
 None
 1.14A 4kn2C-5lv9A:
undetectable		 4kn2C-5lv9A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		5 / 12 ALA A  13
GLY A 349
SER A 352
ILE A   7
GLY A  10
 None
 1.20A 4obwA-5lv9A:
4.1		 4obwA-5lv9A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 CYH A 274
PRO A  93
ASP A 130
 None
 0.88A 4pm5A-5lv9A:
undetectable		 4pm5A-5lv9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 GLU A  57
ARG A  53
GLN A 155
 None
 0.97A 4rtbA-5lv9A:
undetectable		 4rtbA-5lv9A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 ARG A 426
THR A 417
TRP A 420
 None
 0.87A 4ug5A-5lv9A:
undetectable		 4ug5A-5lv9A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 ARG A 426
THR A 417
TRP A 420
 None
 1.02A 4uglA-5lv9A:
undetectable		 4uglA-5lv9A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 TRP A 439
ARG A 435
LEU A 456
 None
 0.98A 5dbyA-5lv9A:
undetectable		 5dbyA-5lv9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 ARG A 426
THR A 417
TRP A 420
 None
 0.95A 5g6cA-5lv9A:
undetectable		 5g6cA-5lv9A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 8 ILE A 227
ILE A 366
ALA A 369
ILE A 370
 None
 0.74A 5mvmA-5lv9A:
undetectable
5mvmB-5lv9A:
undetectable		 5mvmA-5lv9A:
9.29
5mvmB-5lv9A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		5 / 12 LEU A 179
PHE A  49
GLY A 362
MET A  16
LEU A 456
 None
 1.26A 5y2tA-5lv9A:
undetectable		 5y2tA-5lv9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		4 / 5 GLU A  95
VAL A 124
LEU A 501
HIS A 137
 None
 1.47A 6dyoA-5lv9A:
undetectable		 6dyoA-5lv9A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE
(Streptomyces
violaceusniger) 		3 / 3 LEU A 225
ASN A 391
LEU A 237
 None
 0.63A 6exiD-5lv9A:
3.4		 6exiD-5lv9A:
9.85