SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 5lva NAD(P)H-FMN
OXIDOREDUCTASE
(Bacillus
subtilis) 		4 / 6 LEU A  75
TRP A  78
PHE A  62
VAL A 103
 None
 0.92A 1ibgH-5lvaA:
undetectable		 1ibgH-5lvaA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lva NAD(P)H-FMN
OXIDOREDUCTASE
(Bacillus
subtilis) 		6 / 11 ILE A  60
GLN A  63
PHE A  62
LEU A   6
ALA A   7
ILE A 138
 None
 1.47A 3fc6A-5lvaA:
undetectable		 3fc6A-5lvaA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5lva NAD(P)H-FMN
OXIDOREDUCTASE
(Bacillus
subtilis) 		4 / 7 ASN A 120
ALA A 113
TYR A 149
ALA A 107
 None
None
None
FMN  A 201 (-3.3A)
 1.03A 3twpA-5lvaA:
undetectable		 3twpA-5lvaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5lva NAD(P)H-FMN
OXIDOREDUCTASE
(Bacillus
subtilis) 		4 / 7 ASN A 120
ALA A 113
TYR A 149
ALA A 107
 None
None
None
FMN  A 201 (-3.3A)
 1.00A 3twpB-5lvaA:
undetectable		 3twpB-5lvaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5lva NAD(P)H-FMN
OXIDOREDUCTASE
(Bacillus
subtilis) 		4 / 7 ASN A 120
ALA A 113
TYR A 149
ALA A 107
 None
None
None
FMN  A 201 (-3.3A)
 1.01A 3twpC-5lvaA:
undetectable		 3twpC-5lvaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5lva NAD(P)H-FMN
OXIDOREDUCTASE
(Bacillus
subtilis) 		4 / 5 ASN A 120
ALA A 113
TYR A 149
ALA A 107
 None
None
None
FMN  A 201 (-3.3A)
 1.04A 3twpD-5lvaA:
undetectable		 3twpD-5lvaA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5lva NAD(P)H-FMN
OXIDOREDUCTASE
(Bacillus
subtilis) 		4 / 7 TRP A  68
GLY A 108
TYR A 114
ASN A 120
 FMN  A 201 (-4.4A)
FMN  A 201 (-3.6A)
FMN  A 201 (-4.9A)
None
 0.53A 4fgkB-5lvaA:
19.8		 4fgkB-5lvaA:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5lva NAD(P)H-FMN
OXIDOREDUCTASE
(Bacillus
subtilis) 		4 / 6 GLU A 112
ALA A 107
LEU A  66
TYR A 122
 None
FMN  A 201 (-3.3A)
FMN  A 201 (-4.4A)
None
 0.95A 5igiA-5lvaA:
undetectable		 5igiA-5lvaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5lva NAD(P)H-FMN
OXIDOREDUCTASE
(Bacillus
subtilis) 		3 / 3 TYR A  69
ALA A 113
TYR A 114
 FMN  A 201 (-3.3A)
None
FMN  A 201 (-4.9A)
 0.79A 5uunB-5lvaA:
undetectable		 5uunB-5lvaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5lva NAD(P)H-FMN
OXIDOREDUCTASE
(Bacillus
subtilis) 		6 / 12 ILE A  60
GLN A  63
PHE A  62
LEU A   6
ALA A   7
ILE A 138
 None
 1.40A 6a5zL-5lvaA:
undetectable		 6a5zL-5lvaA:
20.37