SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lw0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 5lw0 BASIC
HELIX-LOOP-HELIX,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		4 / 4 LEU A 228
ILE A 254
HIS A 255
VAL A 256
 None
 1.21A 4xyzA-5lw0A:
undetectable		 4xyzA-5lw0A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 5lw0 BASIC
HELIX-LOOP-HELIX,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		5 / 12 LEU A 238
VAL A 250
ILE A 176
VAL A 256
LEU A 287
 None
None
AR6  A 301 (-4.0A)
None
None
 0.97A 4y0pA-5lw0A:
undetectable		 4y0pA-5lw0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 5lw0 BASIC
HELIX-LOOP-HELIX,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		4 / 6 LEU A 140
PHE A 288
ILE A 294
PHE A 291
 None
 1.03A 4y4dA-5lw0A:
undetectable		 4y4dA-5lw0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5lw0 BASIC
HELIX-LOOP-HELIX,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		5 / 9 LEU A 185
ILE A  98
PHE A 172
VAL A 173
GLU A 248
 None
 1.45A 5igzA-5lw0A:
undetectable		 5igzA-5lw0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 5lw0 BASIC
HELIX-LOOP-HELIX,
PUTATIVE, EXPRESSED
(Oryza
sativa) 		4 / 7 SER A 109
ALA A 283
ILE A 254
ALA A 191
 AR6  A 301 (-4.2A)
None
None
None
 0.91A 6ma7A-5lw0A:
undetectable		 6ma7A-5lw0A:
17.04