SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lw3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 12 GLY A  12
GLY A  42
ILE A  75
ALA A  10
VAL A   5
 None
 0.98A 1jg2A-5lw3A:
undetectable		 1jg2A-5lw3A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		3 / 3 SER A 228
GLY A 227
ARG A 195
 None
 0.68A 1t9wA-5lw3A:
undetectable		 1t9wA-5lw3A:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 12 GLN A  72
ALA A  68
TYR A  44
GLY A  12
LEU A  11
 None
 1.36A 2nv4B-5lw3A:
undetectable		 2nv4B-5lw3A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		4 / 7 GLY A 101
THR A 137
MET A 102
SER A 165
 None
 1.14A 2o5yH-5lw3A:
undetectable
2o5yL-5lw3A:
undetectable		 2o5yH-5lw3A:
21.28
2o5yL-5lw3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		4 / 6 TYR A 244
VAL A 262
VAL A 224
VAL A 254
 None
 0.85A 2z97A-5lw3A:
undetectable		 2z97A-5lw3A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 11 LEU A 222
VAL A 252
MET A 209
ILE A 239
ALA A 280
 None
 1.24A 2zbzA-5lw3A:
undetectable		 2zbzA-5lw3A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 9 VAL A 262
ILE A 285
ALA A 280
THR A 320
VAL A 302
 None
 1.25A 3me6C-5lw3A:
undetectable		 3me6C-5lw3A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		6 / 12 ILE A  26
GLY A 101
GLY A  67
ILE A  22
GLU A 139
THR A  36
 None
 1.18A 3q70A-5lw3A:
undetectable		 3q70A-5lw3A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 12 GLY A 150
GLY A 120
LEU A 172
ALA A 167
ASN A 193
 None
 1.29A 3sxjA-5lw3A:
undetectable		 3sxjA-5lw3A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		4 / 4 ASP A  17
ASP A  18
GLY A  14
THR A  73
 None
 1.36A 3tl9B-5lw3A:
undetectable		 3tl9B-5lw3A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 10 GLN A 180
ARG A 134
ASN A 135
GLY A 183
GLY A 131
 None
 1.39A 3v3oD-5lw3A:
undetectable		 3v3oD-5lw3A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 11 GLN A 180
ARG A 134
ASN A 135
GLY A 183
GLY A 131
 None
 1.36A 4a6nB-5lw3A:
undetectable		 4a6nB-5lw3A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 11 GLN A 180
ARG A 134
ASN A 135
GLY A 183
GLY A 131
 None
 1.34A 4a6nC-5lw3A:
undetectable		 4a6nC-5lw3A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		4 / 8 SER A 273
SER A 272
ASN A 293
GLY A 219
 None
 0.99A 4fo4A-5lw3A:
undetectable		 4fo4A-5lw3A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		4 / 4 THR A 184
ARG A 163
GLU A 186
VAL A 161
 None
 0.94A 4odoC-5lw3A:
undetectable		 4odoC-5lw3A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		3 / 3 VAL A 189
ALA A 167
PHE A 198
 None
 0.89A 4z4iA-5lw3A:
undetectable		 4z4iA-5lw3A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		3 / 3 VAL A 189
ALA A 167
PHE A 198
 None
 0.90A 5js1A-5lw3A:
undetectable		 5js1A-5lw3A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		5 / 9 GLY A 109
LEU A  77
VAL A  46
ILE A  85
ILE A  26
 None
 0.95A 5vkqC-5lw3A:
undetectable
5vkqD-5lw3A:
undetectable		 5vkqC-5lw3A:
12.86
5vkqD-5lw3A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_D_LLLD301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5lw3 POLY(BETA-D-MANNURON
ATE) C5 EPIMERASE 6
(Azotobacter
vinelandii) 		4 / 6 ARG A 144
GLU A 145
ASP A 108
GLU A  43
 None
 1.42A 6mn5D-5lw3A:
undetectable		 6mn5D-5lw3A:
12.50