SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lw6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5lw6 DDB_G0293866
(Dictyostelium
discoideum) 		4 / 7 ILE A  42
TYR A 211
PHE A 215
PHE A  24
 None
 1.01A 1e71M-5lw6A:
undetectable		 1e71M-5lw6A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 5lw6 DDB_G0293866
(Dictyostelium
discoideum) 		4 / 7 ILE A  42
TYR A 211
PHE A 215
PHE A  24
 None
 1.02A 1e72M-5lw6A:
2.0		 1e72M-5lw6A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 5lw6 DDB_G0293866
(Dictyostelium
discoideum) 		5 / 12 SER A 116
LEU A 145
TYR A 146
LEU A 166
LEU A 160
 None
 1.20A 1e7wA-5lw6A:
undetectable		 1e7wA-5lw6A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 5lw6 DDB_G0293866
(Dictyostelium
discoideum) 		5 / 10 ALA A  46
PHE A  79
THR A  29
ILE A  36
LEU A  75
 None
 1.24A 2w3aB-5lw6A:
undetectable		 2w3aB-5lw6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5lw6 DDB_G0293866
(Dictyostelium
discoideum) 		4 / 4 TYR A  50
LEU A 214
LEU A 218
HIS A  54
 None
 1.36A 2x7hB-5lw6A:
undetectable		 2x7hB-5lw6A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5lw6 DDB_G0293866
(Dictyostelium
discoideum) 		4 / 4 ILE A 177
GLN A 161
ILE A 170
LEU A  17
 None
 1.27A 3dzyD-5lw6A:
undetectable		 3dzyD-5lw6A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 5lw6 DDB_G0293866
(Dictyostelium
discoideum) 		4 / 5 LEU A  51
ALA A  46
MET A  64
PHE A 215
 None
 1.44A 3uq6A-5lw6A:
undetectable		 3uq6A-5lw6A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 5lw6 DDB_G0293866
(Dictyostelium
discoideum) 		5 / 12 PHE A  91
PHE A  83
PHE A  34
ILE A  27
PHE A  26
 None
 1.34A 6becA-5lw6A:
undetectable
6becB-5lw6A:
undetectable
6becC-5lw6A:
undetectable		 6becA-5lw6A:
16.84
6becB-5lw6A:
16.84
6becC-5lw6A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5lw6 DDB_G0293866
(Dictyostelium
discoideum) 		5 / 12 LEU A 129
THR A 210
VAL A 155
LEU A 107
ALA A  23
 None
 1.20A 6djzA-5lw6A:
undetectable		 6djzA-5lw6A:
21.53