SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lw7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		3 / 3 ASP B 565
ARG B 570
ILE B 307
 None
 0.83A 1a4gB-5lw7B:
undetectable		 1a4gB-5lw7B:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		5 / 12 VAL B 109
LEU B 274
GLY B 110
PRO B 111
PHE B 310
 None
 1.26A 1fdsA-5lw7B:
undetectable		 1fdsA-5lw7B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		5 / 12 GLY B 302
ASN B 305
ASP B 278
VAL B 283
MET B 104
 None
 1.26A 1ffyA-5lw7B:
undetectable		 1ffyA-5lw7B:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		4 / 6 THR B 382
GLN B 410
HIS B 516
ASN B 377
 None
 1.28A 1tt0B-5lw7B:
undetectable		 1tt0B-5lw7B:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		4 / 6 THR B 382
GLN B 410
HIS B 516
ASN B 377
 None
 1.32A 1tt0D-5lw7B:
undetectable		 1tt0D-5lw7B:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		3 / 3 ARG B 304
ARG B 570
PRO B 566
 None
 0.99A 2wljA-5lw7B:
undetectable		 2wljA-5lw7B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		3 / 3 ARG B 304
ARG B 572
PRO B 566
 None
 1.00A 2wljA-5lw7B:
undetectable		 2wljA-5lw7B:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		4 / 6 PHE B 531
LEU B 512
VAL B 385
VAL B 360
 None
 1.03A 2zuhA-5lw7B:
undetectable		 2zuhA-5lw7B:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		4 / 7 VAL B 420
LEU B 458
TYR B 451
ILE B 448
 None
 1.05A 3avpA-5lw7B:
1.8		 3avpA-5lw7B:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		4 / 7 VAL B 207
LEU B 215
GLN B 249
LEU B 245
 None
 1.05A 3qeoB-5lw7B:
undetectable		 3qeoB-5lw7B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		4 / 5 TYR B 153
PHE B 235
PRO B 164
LEU B 268
 None
 1.46A 3tgvC-5lw7B:
undetectable		 3tgvC-5lw7B:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		5 / 11 ALA B 495
LEU B 445
LEU B 488
LEU B 481
ILE B 500
 None
 1.08A 3tqbA-5lw7B:
2.4		 3tqbA-5lw7B:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		5 / 12 GLN B 410
ARG B 210
GLY B 217
GLY B 536
GLU B 534
 None
 0.84A 3v3oB-5lw7B:
undetectable		 3v3oB-5lw7B:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		5 / 11 GLN B 410
ARG B 210
GLY B 217
GLY B 536
GLU B 534
 None
 0.92A 4a6nA-5lw7B:
undetectable		 4a6nA-5lw7B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_B_T1CB392_1
(TETX2 PROTEIN)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		5 / 11 GLN B 410
ARG B 210
GLY B 217
GLY B 536
GLU B 534
 None
 0.91A 4a6nB-5lw7B:
undetectable		 4a6nB-5lw7B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		4 / 7 PHE B 322
TYR B 288
VAL B 286
ILE B 284
 None
 1.12A 4a97E-5lw7B:
undetectable		 4a97E-5lw7B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		4 / 8 PHE B 322
TYR B 288
VAL B 286
ILE B 284
 None
 1.09A 4a97D-5lw7B:
undetectable		 4a97D-5lw7B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		4 / 7 PHE B 322
TYR B 288
VAL B 286
ILE B 284
 None
 1.10A 4a97H-5lw7B:
undetectable		 4a97H-5lw7B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		5 / 12 PRO B 241
GLN B 221
LEU B 245
GLN B 249
LEU B 251
 None
 1.48A 4ac0A-5lw7B:
undetectable		 4ac0A-5lw7B:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		4 / 4 LEU B 488
LEU B 494
GLN B 169
GLU B 271
 None
 1.21A 4i41A-5lw7B:
undetectable		 4i41A-5lw7B:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		3 / 3 ARG B 250
GLU B 483
ARG B 493
 None
 0.99A 4mwvA-5lw7B:
undetectable		 4mwvA-5lw7B:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		3 / 3 ARG B 493
GLU B 240
ARG B 250
 None
 0.83A 4mwvA-5lw7B:
undetectable		 4mwvA-5lw7B:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		5 / 9 LEU B 215
GLY B 218
VAL B 207
VAL B 182
LEU B 186
 None
 1.22A 4qd3A-5lw7B:
undetectable		 4qd3A-5lw7B:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		4 / 7 TYR B 170
GLY B 461
SER B 459
LEU B 463
 None
 1.18A 5bphB-5lw7B:
undetectable		 5bphB-5lw7B:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		3 / 3 CYH B  61
LYS B  64
HIS B  63
 SF4  B 601 (-2.7A)
None
None
 1.22A 5js5A-5lw7B:
undetectable		 5js5A-5lw7B:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		3 / 3 CYH B  65
LYS B  64
HIS B  63
 SF4  B 602 (-2.8A)
None
None
 1.17A 5js5A-5lw7B:
undetectable		 5js5A-5lw7B:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		5 / 9 ASP B 517
ILE B 521
GLY B 372
ILE B 529
ILE B 247
 None
 1.16A 5kr0A-5lw7B:
undetectable		 5kr0A-5lw7B:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		5 / 12 LEU B  94
ALA B 124
TRP B 138
PHE B 154
VAL B 141
 None
 1.41A 6drxA-5lw7B:
undetectable		 6drxA-5lw7B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		5 / 9 THR B 383
GLY B 378
ILE B 379
PHE B 356
ILE B 373
 None
 1.25A 6ebpA-5lw7B:
undetectable		 6ebpA-5lw7B:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5lw7 ABC TRANSPORTER
ATP-BINDING PROTEIN
(Pyrococcus
abyssi) 		5 / 10 THR B 383
GLY B 378
ILE B 379
PHE B 356
ILE B 373
 None
 1.25A 6ebpB-5lw7B:
undetectable		 6ebpB-5lw7B:
7.79