SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lwe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1VIF_A_FOLA1_0 (DIHYDROFOLATE REDUCTASE)	5lwe	C-C CHEMOKINE RECEPTOR TYPE 9 (Homo sapiens)	3 / 3	GLN A 150 ILE A 146 TYR A 145	None OLA A 414 ( 4.9A) OLA A 405 (-3.9A)	0.76A	1vifA-5lweA: undetectable	1vifA-5lweA: 10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZZM_A_SAMA401_0 (UNCHARACTERIZED PROTEIN MJ0883)	5lwe	C-C CHEMOKINE RECEPTOR TYPE 9 (Homo sapiens)	5 / 12	LEU A 87 GLY A 65 VAL A 58 LEU A 312 PHE A 308	79K A 401 (-4.3A) OLA A 412 ( 4.1A) None CLR A 417 ( 4.7A) OLA A 402 (-4.1A)	1.01A	2zzmA-5lweA: undetectable	2zzmA-5lweA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HYT_A_OBNA1104_2 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	5lwe	C-C CHEMOKINE RECEPTOR TYPE 9 (Homo sapiens)	4 / 5	ASP A 94 ASN A 313 ILE A 137 VAL A 262	None None None OLA A 402 ( 4.0A)	1.26A	4hytA-5lweA: 2.2	4hytA-5lweA: 15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1801_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	5lwe	C-C CHEMOKINE RECEPTOR TYPE 9 (Homo sapiens)	4 / 9	ILE A 257 TYR A 234 ILE A 238 ILE A 242	OLA A 402 ( 4.5A) OLA A 404 (-3.8A) None None	0.74A	5vkqB-5lweA: 2.2 5vkqC-5lweA: 2.1	5vkqB-5lweA: 11.35 5vkqC-5lweA: 11.35

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1VIF_A_FOLA1_0","DIHYDROFOLATE REDUCTASE","5lwe","C-C CHEMOKINE RECEPTOR TYPE 9","Homo sapiens",3,"GLN A 150;ILE A 146;TYR A 145","None;OLA A 414 ( 4.9A);OLA A 405 (-3.9A)","0.76A","1vifA-5lweA:undetectable","1vifA-5lweA:10.58"],["2ZZM_A_SAMA401_0","UNCHARACTERIZED PROTEIN MJ0883","5lwe","C-C CHEMOKINE RECEPTOR TYPE 9","Homo sapiens",5,"LEU A  87;GLY A  65;VAL A  58;LEU A 312;PHE A 308","79K A 401 (-4.3A);OLA A 412 ( 4.1A);None;CLR A 417 ( 4.7A);OLA A 402 (-4.1A)","1.01A","2zzmA-5lweA:undetectable","2zzmA-5lweA:22.22"],["4HYT_A_OBNA1104_2","SODIUM\/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA-1","5lwe","C-C CHEMOKINE RECEPTOR TYPE 9","Homo sapiens",4,"ASP A  94;ASN A 313;ILE A 137;VAL A 262","None;None;None;OLA A 402 ( 4.0A)","1.26A","4hytA-5lweA:2.2","4hytA-5lweA:15.64"],["5VKQ_C_PCFC1801_0","NO MECHANORECEPTOR POTENTIAL C ISOFORM L","5lwe","C-C CHEMOKINE RECEPTOR TYPE 9","Homo sapiens",4,"ILE A 257;TYR A 234;ILE A 238;ILE A 242","OLA A 402 ( 4.5A);OLA A 404 (-3.8A);None;None","0.74A","5vkqB-5lweA:2.2;5vkqC-5lweA:2.1","5vkqB-5lweA:11.35;5vkqC-5lweA:11.35"]]