SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lwf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S
(Lama
glama) 		3 / 3 TRP C  39
ALA C  53
VAL C  51
 None
 0.94A 1bdwA-5lwfC:
undetectable
1bdwB-5lwfC:
undetectable		 1bdwA-5lwfC:
5.83
1bdwB-5lwfC:
5.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S
(Lama
glama) 		6 / 12 ALA C  27
MET C  37
ARG C  75
ASN C  80
VAL C  82
ALA C 101
 None
 0.57A 3qxtA-5lwfC:
21.3		 3qxtA-5lwfC:
69.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S
(Lama
glama) 		6 / 12 VAL C   5
MET C  37
ARG C  75
ASN C  80
VAL C  82
ALA C 101
 None
 0.71A 3qxtA-5lwfC:
21.3		 3qxtA-5lwfC:
69.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S
(Lama
glama) 		7 / 12 LEU C   7
ALA C  27
MET C  37
ARG C  75
VAL C  82
ALA C 101
TYR C 117
 None
None
None
None
None
None
ACT  C 202 (-4.4A)
 0.48A 3qxtB-5lwfC:
21.7		 3qxtB-5lwfC:
69.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S
(Lama
glama) 		8 / 12 VAL C   5
ALA C  27
MET C  37
ARG C  75
ASN C  77
VAL C  82
ALA C 101
TYR C 117
 None
None
None
None
None
None
None
ACT  C 202 (-4.4A)
 0.74A 3qxvA-5lwfC:
21.4		 3qxvA-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S
(Lama
glama) 		6 / 12 VAL C   5
ALA C  27
MET C  37
ARG C  75
ALA C 101
TYR C 117
 None
None
None
None
None
ACT  C 202 (-4.4A)
 0.74A 3qxvB-5lwfC:
21.1		 3qxvB-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S
(Lama
glama) 		6 / 12 VAL C   5
MET C  37
ARG C  75
VAL C  82
ALA C 101
TYR C 117
 None
None
None
None
None
ACT  C 202 (-4.4A)
 0.77A 3qxvB-5lwfC:
21.1		 3qxvB-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S
(Lama
glama) 		7 / 11 VAL C   5
ALA C  27
MET C  37
ARG C  75
ASN C  77
VAL C  82
ALA C 101
 None
 0.70A 3qxvC-5lwfC:
21.5		 3qxvC-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S
(Lama
glama) 		6 / 12 ALA C  27
MET C  37
ARG C  75
VAL C  82
ALA C 101
TYR C 117
 None
None
None
None
None
ACT  C 202 (-4.4A)
 0.59A 3qxvD-5lwfC:
21.3		 3qxvD-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S
(Lama
glama) 		5 / 12 VAL C   5
ARG C  75
VAL C  82
ALA C 101
TYR C 117
 None
None
None
None
ACT  C 202 (-4.4A)
 0.86A 3qxvD-5lwfC:
21.3		 3qxvD-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S
(Lama
glama) 		5 / 12 ALA C  27
MET C  37
ARG C  75
ALA C 101
TYR C 117
 None
None
None
None
ACT  C 202 (-4.4A)
 0.58A 3qxvE-5lwfC:
18.5		 3qxvE-5lwfC:
68.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5lwf CAMELID HEAVY-CHAIN
ANTIBODY VARIABLE
FRAGMENT CAB-G10S
(Lama
glama) 		5 / 12 MET C  37
ARG C  75
VAL C  82
ALA C 101
TYR C 117
 None
None
None
None
ACT  C 202 (-4.4A)
 0.54A 3qxvE-5lwfC:
18.5		 3qxvE-5lwfC:
68.80