SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lx0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 188
LEU A 192
ALA A 168
ASN A 165
SER A 142
 None
 1.06A 1dfoA-5lx0A:
undetectable		 1dfoA-5lx0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 188
LEU A 192
ALA A 168
ASN A 165
SER A 142
 None
 1.06A 1dfoB-5lx0A:
undetectable		 1dfoB-5lx0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 188
LEU A 192
ALA A 168
ASN A 165
SER A 142
 None
 1.06A 1dfoC-5lx0A:
undetectable		 1dfoC-5lx0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 188
LEU A 192
ALA A 168
ASN A 165
SER A 142
 None
 1.06A 1dfoD-5lx0A:
undetectable		 1dfoD-5lx0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 188
LEU A 192
ALA A 168
ASN A 165
SER A 142
 None
 1.05A 1eqbA-5lx0A:
undetectable		 1eqbA-5lx0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 188
LEU A 192
ALA A 168
ASN A 165
SER A 142
 None
 1.05A 1eqbB-5lx0A:
undetectable		 1eqbB-5lx0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 188
LEU A 192
ALA A 168
ASN A 165
SER A 142
 None
 1.04A 1eqbC-5lx0A:
undetectable		 1eqbC-5lx0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 188
LEU A 192
ALA A 168
ASN A 165
SER A 142
 None
 1.05A 1eqbD-5lx0A:
undetectable		 1eqbD-5lx0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 159
MET A 197
LEU A 192
ILE A 133
GLY A 132
 None
 1.24A 1g50B-5lx0A:
undetectable		 1g50B-5lx0A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 11 LEU A 159
MET A 197
LEU A 192
ILE A 133
GLY A 132
 None
 1.23A 1g50C-5lx0A:
undetectable		 1g50C-5lx0A:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		7 / 12 ASP A  25
GLU A 134
HIS A 161
HIS A 203
HIS A 224
ARG A 235
ASP A 294
 FE  A 401 (-2.0A)
FE  A 401 ( 2.4A)
None
FE  A 402 (-3.5A)
FE  A 402 (-3.5A)
None
FE  A 402 (-3.9A)
 0.30A 1ituA-5lx0A:
55.2		 1ituA-5lx0A:
38.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		7 / 12 ASP A  25
GLU A 134
HIS A 161
HIS A 203
HIS A 224
ARG A 235
ASP A 294
 FE  A 401 (-2.0A)
FE  A 401 ( 2.4A)
None
FE  A 402 (-3.5A)
FE  A 402 (-3.5A)
None
FE  A 402 (-3.9A)
 0.31A 1ituB-5lx0A:
55.0		 1ituB-5lx0A:
38.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 ILE A  38
VAL A  97
ASP A  96
ALA A 112
SER A 129
 None
 1.23A 1nbhC-5lx0A:
undetectable		 1nbhC-5lx0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 11 ALA A 280
GLY A 250
GLY A 290
ILE A 254
VAL A 339
 None
 1.01A 1pg2A-5lx0A:
undetectable		 1pg2A-5lx0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 10 GLY A 292
MET A 198
ILE A 221
TYR A 156
GLY A  22
 None
 1.38A 1pn0A-5lx0A:
undetectable		 1pn0A-5lx0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 LEU A 201
MET A 197
LEU A 192
ILE A 133
GLY A 132
 None
 1.16A 2j7xA-5lx0A:
undetectable		 2j7xA-5lx0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		4 / 7 ARG A  57
ASP A  47
ASN A  24
PHE A  26
 None
 1.24A 2jc9A-5lx0A:
undetectable		 2jc9A-5lx0A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		4 / 7 ASP A 296
PHE A  26
TYR A  28
PRO A  27
 None
 1.29A 2q6kA-5lx0A:
undetectable		 2q6kA-5lx0A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		3 / 3 LEU A 350
ASN A 193
ARG A 217
 None
 0.84A 2qhfA-5lx0A:
undetectable		 2qhfA-5lx0A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		4 / 4 MET A  29
LEU A 101
ASN A  36
THR A  53
 None
 1.49A 2qk8A-5lx0A:
0.0		 2qk8A-5lx0A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		4 / 7 GLY A 153
ILE A 133
THR A  91
LEU A 152
 None
 0.99A 2xrhA-5lx0A:
undetectable		 2xrhA-5lx0A:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 VAL A 237
LEU A 181
SER A 225
LEU A 159
GLY A 250
 None
 1.22A 3edlB-5lx0A:
undetectable		 3edlB-5lx0A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 9 LEU A 159
THR A 204
HIS A 224
ILE A 221
LEU A 201
 None
None
FE  A 402 (-3.5A)
None
None
 1.08A 3hy7B-5lx0A:
undetectable		 3hy7B-5lx0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		4 / 4 PRO A  27
LEU A 101
ILE A  38
ARG A 104
 None
 1.43A 3w1wA-5lx0A:
undetectable		 3w1wA-5lx0A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		5 / 12 LEU A  45
PHE A  34
ARG A  35
THR A  53
PRO A  49
 None
 1.11A 4m6kA-5lx0A:
undetectable		 4m6kA-5lx0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		3 / 3 SER A 223
TYR A 156
ASP A  25
 None
None
FE  A 401 (-2.0A)
 0.70A 4rp8C-5lx0A:
undetectable		 4rp8C-5lx0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		4 / 6 TYR A 156
ASP A 294
HIS A  23
ILE A 291
 None
FE  A 402 (-3.9A)
FE  A 401 (-3.7A)
None
 1.15A 5ih0A-5lx0A:
undetectable		 5ih0A-5lx0A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5lx0 DIPEPTIDASE
(Aspergillus
fumigatus) 		4 / 8 HIS A 164
ARG A 235
HIS A 233
GLU A 134
 None
None
None
FE  A 401 ( 2.4A)
 1.31A 6mn4C-5lx0A:
undetectable		 6mn4C-5lx0A:
22.28