SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lx8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 141
ALA A 122
LEU A 147
LEU A 203
TYR A 134
 None
 1.16A 1ddsA-5lx8A:
undetectable		 1ddsA-5lx8A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 424
ASP A  75
ASN A 325
TYR A 271
 None
 1.45A 1nbiA-5lx8A:
0.0		 1nbiA-5lx8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 424
ASP A  75
ASN A 325
TYR A 271
 None
 1.48A 1nbiB-5lx8A:
undetectable		 1nbiB-5lx8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ARG A 148
ASN A 120
GLN A 124
ASP A 127
 None
 1.33A 1p6kB-5lx8A:
undetectable		 1p6kB-5lx8A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 343
ASP A 344
ASN A 325
GLU A 502
 None
 1.24A 1rjdA-5lx8A:
undetectable		 1rjdA-5lx8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 343
ASP A 344
ASN A 325
GLU A 502
 None
 1.25A 1rjdB-5lx8A:
undetectable		 1rjdB-5lx8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 343
ASP A 344
ASN A 325
GLU A 502
 None
 1.29A 1rjdC-5lx8A:
undetectable		 1rjdC-5lx8A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ARG A 148
ASN A 120
GLN A 124
ASP A 127
 None
 1.29A 1rs7B-5lx8A:
undetectable		 1rs7B-5lx8A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 141
ALA A 122
LEU A 147
LEU A 203
TYR A 134
 None
 1.17A 1tdrA-5lx8A:
undetectable		 1tdrA-5lx8A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD205_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 GLU A 284
ALA A 283
GLU A 506
MET A 463
SER A 461
 None
 1.33A 1wrlC-5lx8A:
undetectable
1wrlD-5lx8A:
undetectable		 1wrlC-5lx8A:
10.56
1wrlD-5lx8A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 145
GLU A 143
PRO A 213
ALA A 217
 None
 1.11A 2ejfB-5lx8A:
undetectable		 2ejfB-5lx8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 7 ARG A 145
GLU A 143
PRO A 213
ALA A 217
 None
 1.08A 2ejgA-5lx8A:
undetectable		 2ejgA-5lx8A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 LEU A 550
TYR A  69
ILE A  98
ILE A 105
 None
 0.99A 2q8hA-5lx8A:
undetectable		 2q8hA-5lx8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 198
VAL A  47
LEU A 123
GLN A 207
LEU A 203
 None
 1.34A 2rctA-5lx8A:
undetectable		 2rctA-5lx8A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 ILE A 116
THR A 117
LEU A 155
VAL A 165
ILE A 108
 None
 1.20A 2vn0A-5lx8A:
undetectable		 2vn0A-5lx8A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 GLY A 149
HIS A 150
ILE A 162
ALA A 119
 None
 0.94A 2x0pA-5lx8A:
undetectable		 2x0pA-5lx8A:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 THR A 121
LEU A  46
ALA A  50
SER A  49
 None
 0.88A 3kp6A-5lx8A:
undetectable		 3kp6A-5lx8A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 228
GLN A 157
ILE A 108
LEU A 158
 None
 1.06A 3ls4L-5lx8A:
undetectable		 3ls4L-5lx8A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 398
ARG A 424
ASP A 356
 None
 1.28A 3o7wA-5lx8A:
undetectable		 3o7wA-5lx8A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 391
ASP A 318
ASP A 382
 None
NA  A 608 ( 4.3A)
None
 1.00A 3ou7B-5lx8A:
undetectable		 3ou7B-5lx8A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 241
ASP A 237
GLU A 544
 None
 0.66A 3qowA-5lx8A:
undetectable		 3qowA-5lx8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ILE A 423
ILE A 108
MET A 154
TRP A  54
 None
 1.18A 3welA-5lx8A:
undetectable		 3welA-5lx8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 THR A 255
TYR A 265
ARG A 432
LEU A 429
 None
 1.19A 3wipG-5lx8A:
undetectable
3wipH-5lx8A:
undetectable		 3wipG-5lx8A:
15.95
3wipH-5lx8A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 ARG A 432
LEU A 429
THR A 255
TYR A 265
 None
 1.20A 3wipF-5lx8A:
undetectable
3wipJ-5lx8A:
undetectable		 3wipF-5lx8A:
15.95
3wipJ-5lx8A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 254
ASP A 201
ASP A 194
 None
 0.76A 4a6eA-5lx8A:
undetectable		 4a6eA-5lx8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 GLN A 215
ALA A 216
ALA A 219
ALA A 220
LEU A 429
 None
 0.77A 4j6cA-5lx8A:
undetectable		 4j6cA-5lx8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 10 GLN A 215
ALA A 216
ALA A 219
ALA A 220
LEU A 429
 None
 0.77A 4j6cB-5lx8A:
undetectable		 4j6cB-5lx8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLN A 215
ALA A 216
ALA A 219
ALA A 220
LEU A 429
 None
 0.95A 4j6dA-5lx8A:
undetectable		 4j6dA-5lx8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLN A 215
ALA A 216
ALA A 219
ALA A 220
LEU A 429
 None
 0.94A 4j6dB-5lx8A:
undetectable		 4j6dB-5lx8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 12 GLN A 215
ALA A 216
ALA A 219
ALA A 220
LEU A 429
 None
 0.89A 4jbtA-5lx8A:
undetectable		 4jbtA-5lx8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		5 / 11 GLN A 215
ALA A 216
ALA A 219
ALA A 220
LEU A 429
 None
 0.88A 4jbtB-5lx8A:
undetectable		 4jbtB-5lx8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 8 TYR A 228
ARG A 515
ASP A  75
GLU A 506
 None
 1.40A 4kr4C-5lx8A:
undetectable		 4kr4C-5lx8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 111
ILE A  53
GLN A 114
ILE A 108
 None
 1.15A 4w5qA-5lx8A:
undetectable		 4w5qA-5lx8A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ILE A  53
GLN A 114
ILE A 108
ASP A 107
 None
 1.10A 4w5qA-5lx8A:
undetectable		 4w5qA-5lx8A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ILE A  53
GLN A 114
ILE A 108
ASP A 107
 None
 1.19A 4w5tA-5lx8A:
undetectable		 4w5tA-5lx8A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ILE A  53
GLN A 114
ILE A 108
ASP A 107
 None
 1.12A 4z4dA-5lx8A:
undetectable		 4z4dA-5lx8A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 THR A 241
ASP A 237
GLU A 544
 None
 0.67A 5fa8A-5lx8A:
undetectable		 5fa8A-5lx8A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 393
TYR A 394
GLY A 392
GLY A 389
 None
 1.05A 5x7pA-5lx8A:
undetectable		 5x7pA-5lx8A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 457
PHE A 503
ARG A 424
 None
 1.02A 5y9yA-5lx8A:
undetectable		 5y9yA-5lx8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 210
ASN A 281
SER A 285
 None
 1.29A 5yw0A-5lx8A:
undetectable		 5yw0A-5lx8A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 5lx8 SUSD HOMOLOG
(Bacteroides
thetaiotaomicron) 		4 / 6 ILE A  53
GLN A 114
ILE A 108
ASP A 107
 None
 1.16A 6cbdA-5lx8A:
undetectable		 6cbdA-5lx8A:
20.02