SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lx9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 5lx9 SINGLE-CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		6 / 12 TYR H 175
GLN H 228
PHE H 237
VAL H  37
ALA H  97
TRP H 108
 None
 0.57A 1h8sA-5lx9H:
22.9		 1h8sA-5lx9H:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JNN_H_ESTH350_1
(MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN
GAMMA-1 CHAIN
MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN KAPPA
CHAIN)		 5lx9 SINGLE-CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		5 / 10 GLU H  99
TYR H 175
TYR H 188
PHE H 230
TYR H 235
 None
 0.74A 1jnnH-5lx9H:
21.3
1jnnL-5lx9H:
22.6		 1jnnH-5lx9H:
37.11
1jnnL-5lx9H:
35.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lx9 SINGLE-CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  70
GLU H  99
 None
 1.43A 3nloA-5lx9H:
undetectable
3nloB-5lx9H:
undetectable		 3nloA-5lx9H:
19.69
3nloB-5lx9H:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 5lx9 SINGLE-CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		4 / 5 VAL H   2
TYR H  27
ARG H  98
TYR H 107
 None
 0.29A 4m7kH-5lx9H:
22.8		 4m7kH-5lx9H:
41.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA301_0
(THAUMATIN-1)		 5lx9 SINGLE-CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		3 / 3 THR H 157
ASN H 215
SER H 216
 None
 0.56A 4tvtA-5lx9H:
undetectable		 4tvtA-5lx9H:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 5lx9 SINGLE-CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		4 / 5 VAL H  18
ILE H  20
VAL H 114
THR H 112
 None
 0.65A 4xdtA-5lx9H:
0.7		 4xdtA-5lx9H:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lx9 SINGLE-CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  70
GLU H  99
 None
 1.35A 5unuA-5lx9H:
undetectable
5unuB-5lx9H:
undetectable		 5unuA-5lx9H:
19.46
5unuB-5lx9H:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lx9 SINGLE-CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		4 / 7 VAL H  37
TRP H  47
PHE H  70
GLU H  99
 None
 1.33A 5unxA-5lx9H:
undetectable
5unxB-5lx9H:
undetectable		 5unxA-5lx9H:
19.46
5unxB-5lx9H:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUQ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5lx9 SINGLE-CHAIN
VARIABLE FRAGMENT
(Mus
musculus) 		4 / 6 VAL H  37
TRP H  47
PHE H  70
GLU H  99
 None
 1.40A 6auqA-5lx9H:
undetectable
6auqB-5lx9H:
undetectable		 6auqA-5lx9H:
15.29
6auqB-5lx9H:
15.29