SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lxe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZY_A_CHDA237_0
(PHOSPHOLIPASE A2,
MAJOR ISOENZYME)		 5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1
(Rhodococcus
jostii) 		5 / 11 ARG A 297
ILE A 296
ILE A 284
TYR A 202
GLY A 303
 None
 1.20A 2azyA-5lxeA:
undetectable		 2azyA-5lxeA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1
(Rhodococcus
jostii) 		5 / 12 GLY A  70
GLY A 103
THR A  71
THR A  58
ILE A 100
 None
 1.03A 2wa2A-5lxeA:
undetectable		 2wa2A-5lxeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1
(Rhodococcus
jostii) 		4 / 6 THR A  35
GLN A  68
ILE A 192
SER A  33
 None
 0.82A 3peoG-5lxeA:
undetectable		 3peoG-5lxeA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1
(Rhodococcus
jostii) 		5 / 12 GLY A  23
PHE A  14
SER A  10
GLU A  27
ALA A  26
 None
 1.19A 3t7sA-5lxeA:
undetectable		 3t7sA-5lxeA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1
(Rhodococcus
jostii) 		3 / 3 GLN A 316
PHE A 319
TYR A   7
 None
 0.96A 3ucjB-5lxeA:
undetectable		 3ucjB-5lxeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1
(Rhodococcus
jostii) 		3 / 3 GLN A 316
PHE A 319
TYR A   7
 None
 1.00A 3ucjA-5lxeA:
undetectable		 3ucjA-5lxeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1
(Rhodococcus
jostii) 		4 / 8 ARG A 269
GLU A 266
GLU A 268
ARG A  44
 None
 1.22A 4bqfB-5lxeA:
undetectable		 4bqfB-5lxeA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1
(Rhodococcus
jostii) 		4 / 8 GLN A 316
GLN A  13
ASN A 244
THR A 245
 None
 1.04A 4d1yA-5lxeA:
undetectable
4d1yB-5lxeA:
undetectable		 4d1yA-5lxeA:
19.77
4d1yB-5lxeA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1
(Rhodococcus
jostii) 		3 / 3 ARG A 318
LEU A 322
GLU A 321
 GOL  A 401 ( 4.7A)
GOL  A 401 ( 4.9A)
GOL  A 401 (-3.7A)
 0.74A 4l3gF-5lxeA:
undetectable		 4l3gF-5lxeA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1
(Rhodococcus
jostii) 		4 / 7 LEU A 251
VAL A  73
GLU A 229
SER A  72
 None
 1.04A 5umwA-5lxeA:
undetectable
5umwF-5lxeA:
undetectable		 5umwA-5lxeA:
15.84
5umwF-5lxeA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 5lxe F420-DEPENDENT
GLUCOSE-6-PHOSPHATE
DEHYDROGENASE 1
(Rhodococcus
jostii) 		4 / 6 LEU A  95
THR A  58
GLY A  61
ARG A  99
 None
 1.34A 6gtqB-5lxeA:
undetectable
6gtqD-5lxeA:
undetectable		 6gtqB-5lxeA:
18.96
6gtqD-5lxeA:
9.28