SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5lxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5lxf MACROPHAGE
COLONY-STIMULATING
FACTOR 1
(Homo
sapiens) 		4 / 7 LEU A  80
GLN A  81
PHE A 121
LEU A  19
 None
 1.02A 3ag2C-5lxfA:
undetectable		 3ag2C-5lxfA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5lxf MACROPHAGE
COLONY-STIMULATING
FACTOR 1
(Homo
sapiens) 		4 / 5 VAL A  57
GLU A  96
LYS A 100
PHE A  37
 None
 1.45A 3rv5C-5lxfA:
undetectable
3rv5D-5lxfA:
undetectable		 3rv5C-5lxfA:
19.41
3rv5D-5lxfA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5lxf MACROPHAGE
COLONY-STIMULATING
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A  22
LEU A  19
LEU A  16
ILE A  77
THR A 124
 None
 1.07A 4f4dA-5lxfA:
undetectable		 4f4dA-5lxfA:
16.86